scholarly journals Carbetocin In Prevention of Uterine Atony Following Delivery by Cesarean Section in Population Who Experienced Postpartum Hemorrhage: Costs in Polish Settings

2016 ◽  
Vol 19 (3) ◽  
pp. A176 ◽  
Author(s):  
K Pacocha ◽  
I Pieniazek ◽  
M Sobkowski ◽  
Z Celewicz ◽  
J Kalinka ◽  
...  
Author(s):  
Yaneth Gil-Rojas ◽  
Pieralessandro Lasalvia ◽  
Fabián Hernández ◽  
Camilo Castañeda-Cardona ◽  
Diego Rosselli

Objective To assess the cost-effectiveness of carbetocin versus oxytocin for prevention of postpartum hemorrhage (PPH) due to uterine atony after vaginal delivery/cesarean section in women with risk factors for bleeding. Methods A decision tree was developed for vaginal delivery and another one for cesarean, in which a sequential analysis of the results was obtained with the use of carbetocin and oxytocin for prevention of PPH and related consequences. A third-party payer perspective was used; only direct medical costs were considered. Incremental costs and effectiveness in terms of quality-adjusted life years (QALYs) were evaluated for a one-year time horizon. The costs were expressed in 2016 Colombian pesos (1 USD = 3,051 Col$). Results In the vaginal delivery model, the average cost of care for a patient receiving prophylaxis with uterotonic agents was Col$ 347,750 with carbetocin and Col$ 262,491 with oxytocin, while the QALYs were 0.9980 and 0.9979, respectively. The incremental cost-effectiveness ratio is above the cost-effectiveness threshold adopted by Colombia. In the model developed for cesarean section, the average cost of a patient receiving prophylaxis with uterotonics was Col$ 461,750 with carbetocin, and Col$ 481,866 with oxytocin, and the QALYs were 0.9959 and 0.9926, respectively. Carbetocin has lower cost and is more effective, with a saving of Col$ 94,887 per avoided hemorrhagic event. Conclusion In case of elective cesarean delivery, carbetocin is a dominant alternative in the prevention of PPH compared with oxytocin; however, it presents higher costs than oxytocin, with similar effectiveness, in cases of vaginal delivery.


Author(s):  
Lino Arturo Rojas Pérez ◽  
Lino Arturo Rojas Cruz ◽  
María Daniela Villagómez Vega ◽  
Augusto Ernesto Rojas Cruz ◽  
Andrés Eduardo Rojas Cruz

  Introduction: Postpartum hemorrhage is blood loss greater than 500 mL after a normal delivery or more than 1000 mL after a cesarean section, or any postpartum bleeding regardless of the amount causing hemodynamic instability. The uterine blood flow in a term pregnancy is approximately 500 to 700 mL/min, for this reason, a patient who presents this complication, in a few minutes, can be drained and compromise her life. Objective: To determine the efficacy of the intrauterine compression, balloon in the management of postpartum hemorrhage due to hypotonia or uterine atony, at the General Teaching Provincial Hospital of Riobamba from October 2015 to September 2016. Methodology: The effectiveness of the use of the intrauterine compression balloon after the failure of pharmacological management was analyzed and statistical evaluation was applied to determine the efficacy of this method for the management of this pathology. Results: It was placed in 23 patients who presented postpartum hemorrhage due to hypotonia or uterine atony, and it had an effectiveness of 94.4% after a vaginal delivery and 80% after a cesarean section. Reaffirming that it is an excellent option in the management of this type of complications. Conclusions: Postpartum hemorrhage is the second cause of maternal death nationwide, technical and timely action will help reduce maternal morbidity and mortality that this pathology can present; the use of the intrauterine hydrostatic compression balloon is an excellent alternative prior to the surgical management of this pathology. Keywords: postpartum hemorrhage, uterine bleeding, uterine tamponade with balloon. RESUMEN Introducción: La hemorragia posparto es la pérdida sanguínea mayor de 500 mL luego de un parto normal o más de 1000 mL luego de una cesárea, o cualquier sangrado posparto independientemente de la cantidad que cause inestabilidad hemodinámica. El riego sanguíneo uterino en un embarazo a término es de aproximadamente 500 a 700 mL/min por tal motivo, una paciente que presente esta complicación, en pocos minutos puede quedar exangüe y comprometer si vida. Objetivo: Determinar la eficacia del balón de compresión intrauterino en el manejo de la hemorragia posparto por hipotonía o atonía uterina, en el Hospital Provincial General Docente de Riobamba de Octubre del 2015 a septiembre del 2016. Metodología: Se analizó la efectividad del uso del balón de compresión intrauterina luego del fracaso del manejo farmacológico y se aplicó la evaluación estadística para determinar la eficacia de este método para el manejo de esta patología. Resultados: Se colocó en 23 pacientes que presentaron hemorragia posparto por hipotonía o atonía uterina, y se tuvo una efectividad del 94.4 por ciento luego de un parto vaginal y del 80% luego de una cesárea. Reafirmando que es una excelente opción en el manejo de este tipo de complicaciones. Conclusiones: La hemorragia posparto es la segunda causa de muerte materna a nivel nacional, el accionar técnico y oportuno ayudará a disminuir la morbimortalidad materna que puede presentar esta patología; la utilización del balón de compresión hidrostático intrauterino es una excelente alternativa previo al manejo quirúrgico de esta patología. Palabras clave: hemorragia posparto, hemorragia uterina, taponamiento uterino con balón.


2018 ◽  
Vol 8 (6) ◽  
pp. 178-183
Author(s):  
Dinh Nguyen Gia ◽  
Thanh Cao Ngoc

Background: Postpartum hemorrhage (PPH) remains a significant contributor to maternal morbility and mortality and accounts for 31% of maternal death in Vietnam. The most common cause of PPH is uterine atony. Recently, uterine tamponade using intrauterine condom appears to be an effective tool in the management of intractable PPH. Objectives: To evaluate the success of condom as a tamponade to arrest intractable PPH due to uterine atony in patients not responding to medical management. Materials and Methods: The study was designed as a cross-sectional and descriptive, included 32 patients who underwent condom balloon tamponade at Kontum Provincial Hospital from 1/2012 to 8/2016. Results: 32 women (mean age 25.71 ± 6.45 years range, 16 - 39) underwent condom balloon tamponade for PPH controls. 29 patients (90.62%) successfully responded the tamponade therapy by the use of condom catheter. Three patients (9.37%) required hysterectomy. Conclusions: Condom catheter balloon effectively controls the intractable PPH due to uterine atony. Key words: PPH (Pospartum hemorrhage), Tamponade, Condom catheter balloon, Uterine atony


2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Nevein Gerges Fahmy ◽  
Fahmy Saad Latif Eskandar ◽  
Walid Albasuony Mohammed Ahmed Khalil ◽  
Mohammed Ibrahim Ibrahim Sobhy ◽  
Amin Mohammed Al Ansary Amin

Abstract Background Postpartum hemorrhage (PPH) is one of the leading causes of maternal mortality and morbidity worldwide. It is believed that hemostatic imbalance secondary to release of tissue plasminogen activator (tPA) and subsequent hyperfibrinolysis plays a major role in PPH pathogenesis. Antifibrinolytic drugs such as tranexamic acid (TXA) are widely used in hemorrhagic conditions associated with hyperfibrinolysis. TXA reduced maternal death due to PPH and its use as a part of PPH treatment is recommended, and in recent years, a number of trials have investigated the efficacy of prophylactic use of TXA in reducing the incidence and the severity of PPH. The study is aiming to assess the efficacy of tranexamic acid in reducing blood loss throughout and after the lower segment cesarean section and reducing the risk of postpartum hemorrhage. Results The amount of blood loss was significantly lower in the study group than the control group (416.12±89.95 and 688.68±134.77 respectively). Also the 24-h postoperative hemoglobin was significantly higher in the study group (11.66±0.79 mg/dl) compared to the control group (10.53±1.07mg/dl), and the 24-h postoperative hematocrit value was significantly higher in the study group (34.99±2.40) compared to control (31.62±3.22). Conclusion Prophylactic administration of tranexamic acid reduces intraoperative and postoperative bleeding in cesarean section and the incidence of postpartum hemorrhage.


2009 ◽  
Vol 107 ◽  
pp. S193-S193
Author(s):  
X. Gong ◽  
L. Ma ◽  
X. Bian ◽  
J. Liu ◽  
J. Gao

Author(s):  
Renu Jain

Background: In low-resource countries, Postpartum Hemorrhage (PPH) is the leading cause of maternal mortality. The intrauterine balloon tamponade was recently incorporated into the strategy to manage uterine atony. There are many types of tamponades. Among them, the condom catheter seems to be an efficient and economic intervention for the treatment of PPH in low-resource countries. The aim of present study was to evaluate the effectiveness of the condom catheter balloon in treating postpartum hemorrhage refractory to medical treatment.Methods: The retrospective analysis of 22 cases of PPH, treated with a condom catheter as a conservative therapeutic option, was done in department of Obstetrics and Gynaecology, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India.Results: The condom catheter was successful in controlling PPH in 90.9% cases. It was effective in 94.44% women with uterine atony, who did not respond to uterotonic drugs. It was also effective in one case of placental implantation site bleeding and two cases of deranged coagulation function. In 2 cases it failed to control PPH and peripartum hysterectomy was done. The volume of saline solution used to fill the balloon was from 150 -350 ml and the time for which the balloon remained inflated was 36-48 hours. No case of febrile morbidity and wound sepsis was noted. There was no maternal death.Conclusions: Its ease of use and high effectiveness make condom catheter a useful approach for the conservative management of PPH. This device reduces bleeding, shortens the hospital stay and avoids the need for more aggressive procedures.


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