Cardiomyocyte calcium cycling in a naturally occurring German shepherd dog model of inherited ventricular arrhythmia and sudden cardiac death

Background: Antidepressants are one of the most prescribed medications, particularly for patients with mental disorders. Nevertheless, there are still limited data regarding the risk of ventricular arrhythmia (VA) and sudden cardiac death (SCD) associated with these medications. Thus, we performed systemic review and meta-analysis to characterize the risks of VA and SCD among patients who used common antidepressants. Methods: A literature search for studies that reported risk of ventricular arrhythmias and sudden cardiac death in antidepressant use from MEDLINE, EMBASE, and Cochrane Database from inception through September 2020. A random-effects model network meta-analysis model was used to analyze the relation between antidepressants and VA/SCD. Surface Under Cumulative Ranking Curve (SUCRA) was used to rank the treatment for each outcome. Results: The mean study sample size was 355,158 subjects. Tricyclic antidepressant (TCA) patients were the least likely to develop ventricular arrhythmia events/sudden cardiac deaths at OR 0.24, 0.028–1.2, OR 0.32 (95% CI 0.038–1.6) for serotonin and norepinephrine reuptake inhibitors (SNRI), and OR 0.36 (95% CI 0.043, 1.8) for selective serotonin reuptake inhibitors (SSRI), respectively. According to SUCRA analysis, TCA was on a higher rank compared to SNRI and SSRI considering the risk of VA/SCD. Conclusion: Our network meta-analysis demonstrated the low risk of VA/SCD among patients using antidepressants for SNRI, SSRI and especially, TCA. Despite the relatively lowest VA/SCD in TCA, drug efficacy and other adverse effects should be taken into account in patients with mental disorders.

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Brugada Syndrome: Fatal Consequences of a Must-Not-Miss Diagnosis

Critical Care Nurse ◽

10.4037/ccn2021499 ◽

2021 ◽

Vol 41 (5) ◽

pp. 15-22

Author(s):

L. Douglas Smith ◽

Sarah Gast ◽

Danielle F. Guy

Keyword(s):

At Risk ◽

Critical Care ◽

Sudden Cardiac Death ◽

Ventricular Arrhythmia ◽

Brugada Syndrome ◽

Cardiac Death ◽

Lifestyle Modification ◽

Genetic Disorder ◽

Cardiac Conduction ◽

St Segment Elevation

Background Brugada syndrome is a genetic disorder of cardiac conduction that predisposes patients to spontaneous ventricular arrhythmia and sudden cardiac death. Although Brugada syndrome is one of the most common causes of sudden cardiac death, patients presenting with the syndrome often go misdiagnosed. This error has potentially fatal consequences for patients, who are at risk for sudden cardiac death without appropriate management. Objective To increase the critical care professional’s knowledge of Brugada syndrome through detailed description of the characteristic electrocardiographic findings, an algorithmic approach to electrocardiogram evaluation, and a case report of a patient with a previously missed diagnosis of Brugada syndrome. The essential concepts of epidemiology, pathophysiology, clinical presentation, risk stratification, and management are reviewed for critical care professionals who may encounter patients with the syndrome. Diagnosis Patients typically present with syncope or cardiac arrest and an abnormal electrocardiographic finding of ST-segment elevation in the precordial leads. The diagnosis of Brugada syndrome centers on identification of its electrocardiographic characteristics by critical care professionals who routinely evaluate electrocardiograms. Critical care professionals, especially nurses and advanced practice nurses, should be proficient in recognizing the electrocardiographic appearance of Brugada syndrome and initiating appropriate management. Interventions Management strategies include prevention of sudden cardiac death through lifestyle modification and placement of an implantable cardioverter-defibrillator. Critical care professionals should be aware of commonly used medications that may exacerbate ventricular arrhythmia and place patients at risk for sudden cardiac death. Conclusion Increased awareness of Brugada syndrome among critical care professionals can decrease patient morbidity and mortality.

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Late gadolinium enhancement identified with cardiac magnetic resonance imaging in sarcoidosis patients is associated with long-term ventricular arrhythmia and sudden cardiac death

Heart Lung and Circulation ◽

10.1016/j.hlc.2015.06.554 ◽

2015 ◽

Vol 24 ◽

pp. S349

Author(s):

J. Nadel ◽

T. Lancefield ◽

A. Voskoboinik ◽

A. Taylor

Keyword(s):

Magnetic Resonance Imaging ◽

Cardiac Magnetic Resonance ◽

Late Gadolinium Enhancement ◽

Sudden Cardiac Death ◽

Magnetic Resonance ◽

Ventricular Arrhythmia ◽

Cardiac Death ◽

Resonance Imaging ◽

Gadolinium Enhancement

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Ventricular Arrhythmia-Free Survival Following Therapeutic Hypothermia in Patients with Sudden Cardiac Death Due to Ventricular Tachycardia or Fibrillation

International Journal of Clinical Medicine ◽

10.4236/ijcm.2017.85028 ◽

2017 ◽

Vol 08 (05) ◽

pp. 293-305 ◽

Cited By ~ 1

Author(s):

Basil M. Saour ◽

Yong H. Ji ◽

Edward F. Philbin ◽

Henry T. Tan ◽

Duy T. Nguyen ◽

...

Keyword(s):

Ventricular Tachycardia ◽

Sudden Cardiac Death ◽

Ventricular Arrhythmia ◽

Therapeutic Hypothermia ◽

Cardiac Death ◽

Free Survival

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Description of Ventricular Arrhythmia after Taking Herbal Medicines in Middle-Aged Couples

Case Reports in Cardiology ◽

10.1155/2020/6061958 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Mohammad Ali Zakeri ◽

Vahid Mohammadi ◽

Gholamreza Bazmandegan ◽

Maryam Zakeri

Keyword(s):

Cardiac Arrest ◽

Heart Disease ◽

Ventricular Tachycardia ◽

Sudden Cardiac Death ◽

Ventricular Arrhythmia ◽

Cardiac Death ◽

Ventricular Arrhythmias ◽

Herbal Medicines ◽

Medicinal Herbs ◽

History Of

Medicinal herbs and some derivatives have been used in the treatment of heart disease which is rarely responsible for ventricular arrhythmias and cardiac arrest. Ventricular tachycardia (VT) increases the risk of sudden cardiac death (SCD). However, only a few reports are available about the cardiac ventricular arrhythmia followed by taking herbal medicines. We present two patients (a couple) without a history of heart disease who referred to the hospital with ventricular arrhythmia.

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Secondary prevention of sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy

ESC CardioMed ◽

10.1093/med/9780198784906.003.0559 ◽

2018 ◽

pp. 2358-2361

Author(s):

Katja Zeppenfeld ◽

Sebastiaan R. D. Piers

Keyword(s):

Sudden Cardiac Death ◽

Ventricular Arrhythmia ◽

Secondary Prevention ◽

Right Ventricular ◽

Cardiac Death ◽

Beta Blockers ◽

Arrhythmogenic Right Ventricular Cardiomyopathy ◽

Ventricular Cardiomyopathy ◽

Recurrence Rates ◽

First Line Therapy

Sustained ventricular tachycardia (VT) and (aborted) sudden cardiac death are the presenting symptoms in 23–57% and 3–13% of patients who are diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC), respectively. Implantation of an implantable cardioverter defibrillator (ICD) is recommended in patients with a history of aborted sudden cardiac death, haemodynamically poorly tolerated VT, and unexplained syncope, and should be considered in patients with haemodynamically well-tolerated sustained VT. Appropriate ICD intervention rates of up to 15%/year are observed in patients implanted for secondary prevention, the majority triggered by rapid and thereby potentially fatal monomorphic VT. Although life-saving, ICD therapy does not prevent ventricular arrhythmias, and therapeutic options to control ventricular arrhythmia burden are required. Beta blockers and sotalol are typically applied as first-line therapy, the latter mainly based on a study with serial programmed stimulation testing. Amiodarone may be superior in selected patients but data are based on small cohorts - large, prospective, observational and randomized trials are lacking. Up to 97% of ventricular arrhythmia episodes in ARVC are monomorphic VT with scar-related reentry as the dominant underlying mechanism, often involving subepicardial scar layers. Catheter ablation can result in a significant reduction of the ventricular arrhythmia burden with VT recurrence rates of 10–15%/year if a combined endocardial–epicardial ablation approach is performed in experienced tertiary referral centres.

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