Abstract No. 115: Comparison between noncontrast gradient recalled echo (GRE) and contrast-enhanced MRV with blood pool agent to detect deep vein thrombosis (DVT)

Objective. Deep vein thrombosis (DVT) is a disease caused by abnormal blood clots in deep veins. Accurate segmentation of DVT is important to facilitate the diagnosis and treatment. In the current study, we proposed a fully automatic method of DVT delineation based on deep learning (DL) and contrast enhanced magnetic resonance imaging (CE-MRI) images. Methods. 58 patients (25 males; 28~96 years old) with newly diagnosed lower extremity DVT were recruited. CE-MRI was acquired on a 1.5 T system. The ground truth (GT) of DVT lesions was manually contoured. A DL network with an encoder-decoder architecture was designed for DVT segmentation. 8-Fold cross-validation strategy was applied for training and testing. Dice similarity coefficient (DSC) was adopted to evaluate the network’s performance. Results. It took about 1.5s for our CNN model to perform the segmentation task in a slice of MRI image. The mean DSC of 58 patients was 0.74± 0.17 and the median DSC was 0.79. Compared with other DL models, our CNN model achieved better performance in DVT segmentation (0.74± 0.17 versus 0.66±0.15, 0.55±0.20, and 0.57±0.22). Conclusion. Our proposed DL method was effective and fast for fully automatic segmentation of lower extremity DVT.

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Diagnosing upper extremity deep vein thrombosis with non-contrast-enhanced Magnetic Resonance Direct Thrombus Imaging: A pilot study

Thrombosis Research ◽

10.1016/j.thromres.2018.01.015 ◽

2018 ◽

Vol 163 ◽

pp. 47-50 ◽

Cited By ~ 5

Author(s):

C.E.A. Dronkers ◽

F.A. Klok ◽

G.R. van Haren ◽

J. Gleditsch ◽

E. Westerlund ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Pilot Study ◽

Magnetic Resonance ◽

Upper Extremity ◽

Vein Thrombosis ◽

Thrombus Imaging ◽

Contrast Enhanced ◽

Deep Vein

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Feasibility of identifying deep vein thrombosis characteristics with contrast enhanced MR-Venography

Phlebology The Journal of Venous Disease ◽

10.1177/0268355514529697 ◽

2014 ◽

Vol 29 (1_suppl) ◽

pp. 119-124 ◽

Cited By ~ 11

Author(s):

CWKP Arnoldussen ◽

RHW Strijkers ◽

DMJ Lambregts ◽

MJ Lahaye ◽

R de Graaf ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Interobserver Agreement ◽

Average Duration ◽

Femoral Vein ◽

Mr Venography ◽

Common Femoral Vein ◽

Vein Thrombosis ◽

Contrast Enhanced ◽

The Common ◽

Deep Vein

Purpose To assess the feasibility of identifying deep vein thrombosis characteristics with contrast enhanced magnetic resonance venography. Materials and Methods A total of 53 cases of deep vein thrombosis extending in and/or above the common femoral vein were evaluated by 4 independent observers (2 expert, 2 novice) using pre-determined characteristics to determine the thrombosis present to be acute, sub-acute or old. If present, chronic remnants of a previous deep vein thrombosis were reported. Additionally these image qualifications were compared to the reported duration of complaints. Results In all cases all observers were able to qualify the thrombosis. The interobserver agreement between the experts was excellent (kappa 0.97) and good between expert and novice (kappa 0.82). Thrombosis identified as acute had an average duration of complaints of 6,5 (2–13) days, sub‐acute 13 (8–18) days and old 22 (15–32) days. Conclusion Qualification of thrombosis as acute, sub-acute or old and identification of chronic remnants of DVT with CE-MRV using routinely identifiable characteristics is feasible and reproducible with good to excellent interobserver agreement.

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Significance of Contrast Enhanced Rapid MR Sequence(True FISP) in Deep Vein Thrombosis

Ewha Medical Journal ◽

10.12771/emj.1999.22.3.173 ◽

1999 ◽

Vol 22 (3) ◽

pp. 173

Author(s):

Jeong-Hyun Yoo ◽

Soo-Seung Choi

Keyword(s):

Deep Vein Thrombosis ◽

Vein Thrombosis ◽

True Fisp ◽

Contrast Enhanced ◽

Deep Vein

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Detection of Deep Vein Thrombosis: Combined Flow and Blood Pool Radionuclide Venography vs Contrast Venography

Angiology ◽

10.1177/000331979104201004 ◽

1991 ◽

Vol 42 (10) ◽

pp. 796-804 ◽

Cited By ~ 2

Author(s):

Biray Caner ◽

Mustafa Ozmen ◽

Alp Dincer ◽

Ozlem Kapucu ◽

Coskun Bekdik

Keyword(s):

Deep Vein Thrombosis ◽

Blood Pool ◽

Vein Thrombosis ◽

Combined Flow ◽

Deep Vein ◽

Radionuclide Venography

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Perivascular Perfusion on Contrast-Enhanced Ultrasound (CEUS) Is Associated with Inflammation in Patients with Acute Deep Vein Thrombosis

Thrombosis and Haemostasis ◽

10.1160/th17-05-0332 ◽

2017 ◽

Vol 117 (11) ◽

pp. 2146-2155 ◽

Cited By ~ 3

Author(s):

Mathias Kaspar ◽

Stephan Imfeld ◽

Sasan Partovi ◽

Markus Aschwanden ◽

Thomas Baldi ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Inflammatory Markers ◽

Thrombus Formation ◽

Contrast Enhanced Ultrasound ◽

Direct Evaluation ◽

Vein Thrombosis ◽

Contrast Enhanced ◽

Acute Deep Vein Thrombosis ◽

Deep Vein

Background Inflammatory processes of the venous wall in acute deep vein thrombosis (DVT) play a role in thrombus formation and resolution. However, direct evaluation of the perivascular inflammation is currently not feasible.Objective To assess perivascular perfusion in acute proximal DVT using contrast-enhanced ultrasound (CEUS) reflecting perivenous inflammation and its association with systemic inflammatory markers in a single-centre, prospective observational study.Patients/Methods Twenty patients with proximal DVT underwent CEUS imaging in the thrombosed and contralateral popliteal vein at baseline and after 2 weeks and 3 months. Perfusion was quantified by measuring peak enhancement (PE) and wash-in rate (WiR) in a perivenous region after bolus injection of the contrast agent. High-sensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6) were determined at the time of each CEUS imaging.Results PE and WiR were significantly higher in the thrombosed compared with the unaffected leg at baseline (1,007 vs. 34 au and 103 vs. 4 au/s) and 2-week follow-up (903 vs. 35 au and 70 vs. 4 au/s). Compared with baseline, PE and WiR in the thrombosed leg significantly decreased to 217 au and 18 au/s at 3-month follow-up.At baseline, hsCRP and IL-6 were elevated at 20.1 mg/mL and 8.2 pg/mL and decreased significantly to 2.8 mg/mL and 2.6 pg/mL at 2-week follow-up, remaining low after 3 months. There was a weak association between the level of inflammatory markers and the CEUS parameters at baseline on the thrombosed leg.Conclusion Elevated perivascular perfusion assessed by CEUS imaging is associated with the inflammatory response in acute DVT.

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Non-contrast-enhanced magnetic resonance imaging: Objective figures in differentiation between acute and chronic deep venous thrombosis in the lower extremities

Phlebology The Journal of Venous Disease ◽

10.1177/0268355520939375 ◽

2020 ◽

Vol 35 (10) ◽

pp. 777-783

Author(s):

Chih-Chen Kao ◽

Chien-Wei Chen ◽

Yuan-Hsi Tseng ◽

Yuan-Hsiung Tsai ◽

Shih-Chung Wang ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Deep Vein Thrombosis ◽

Magnetic Resonance ◽

Venous Thrombosis ◽

Lower Extremities ◽

Interrater Agreement ◽

Resonance Imaging ◽

Vein Thrombosis ◽

Contrast Enhanced ◽

Deep Vein

Background Deep vein thrombosis is a severe health problem. Treatment options may differ between acute and chronic deep vein thrombosis. Thus, distinguishing acute from chronic deep vein thrombosis is essential for patients with deep vein thrombosis. Triggered angiography non-contrast enhanced is an innovative magnetic resonance imaging protocol that may provide objective evidence in differentiating acute from chronic deep vein thrombosis. Method We prospectively collected information on consecutive patients who had been evaluated through triggered angiography non-contrast enhanced magnetic resonance imaging for venous pathology in their lower extremities at a vascular wound care center in a tertiary hospital between April 2017 and January 2020. Patients included were divided into two groups with the onset time cutoff point of 21 days. All were undergone non-contrast-enhanced magnetic resonance imaging evaluation. Non-contrast-enhanced magnetic resonance imaging images were evaluated by a radiologist, and lower extremity venous thrombosis, collateral-vein development, and subcutaneous honeycombing were emphasized. Cohen’s kappa coefficient was used to measure interrater agreement between the development of collateral veins, subcutaneous honeycombing, and symptom onset over 21 days. Results Interrater agreement analysis revealed that the development of collateral veins was substantially correlated with the onset of symptoms over 21 days (Table 1). Additionally, the development of subcutaneous honeycombing detected through triggered angiography non-contrast enhanced magnetic resonance imaging also substantially agreed with the onset of symptoms over 21 days (Table 2). Conclusion The diagnostic power of triggered angiography non-contrast enhanced magnetic resonance imaging in deep vein thrombosis is rival to current gold standard, color Doppler sonography. Triggered angiography non-contrast enhanced magnetic resonance imaging provides objective information on onset timing in patients with deep vein thrombosis that could differentiate acute from chronic deep vein thrombosis and provides guidance for treatment planning.

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