Percutaneous microwave ablation for colorectal cancer liver metastasis: initial results

2014 ◽  
Vol 25 (3) ◽  
pp. S32
Author(s):  
W. Shady ◽  
E.N. Petre ◽  
J.P. Erinjeri ◽  
M. Gonen ◽  
S.B. Solomon ◽  
...  
2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Valentina Tassi ◽  
Claudia Mosillo ◽  
Massimiliano Mutignani ◽  
Roberto Cirocchi ◽  
Mark Ragusa ◽  
...  

Microwave ablation is a safe and effective interventional approach, widely used in the treatment of unresectable primary or metastatic hepatic lesions. Thoracobiliary fistula is a rare postablation complication that can be treated with a conservative or surgical approach. We reviewed aetiology, pathogenesis, clinical picture, diagnostic possibilities, and therapeutic options for biliothoracic fistula developed after microwave ablation of liver metastasis. Furthermore, we reported our experience of successful conservative management of a nonhealing thoracobiliary fistula occurred after percutaneous thermal ablation of colorectal cancer liver metastasis. Our case supports a conservative approach based on percutaneous biliary system decompression and synthetic glue embolization for the treatment of combined biliopleural and biliobronchial fistula.


Oncogene ◽  
2021 ◽  
Author(s):  
Senlin Zhao ◽  
Bingjie Guan ◽  
Yushuai Mi ◽  
Debing Shi ◽  
Ping Wei ◽  
...  

AbstractGlycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. A series of lncRNAs have been identified to function as oncogenic molecules by regulating glycolysis. However, the roles of glycolysis-related lncRNAs in regulating colorectal cancer liver metastasis (CRLM) remain poorly understood. In the present study, the expression of the glycolysis-related lncRNA MIR17HG gradually increased from adjacent normal to CRC to the paired liver metastatic tissues, and high MIR17HG expression predicted poor survival, especially in patients with liver metastasis. Functionally, MIR17HG promoted glycolysis in CRC cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis. More interestingly, lactate accumulated via glycolysis activated the p38/Elk-1 signaling pathway to promote the transcriptional expression of MIR17HG in CRC cells, forming a positive feedback loop, which eventually resulted in persistent glycolysis and the invasion and liver metastasis of CRC cells. In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM.


2003 ◽  
Vol 90 (12) ◽  
pp. 1556-1564 ◽  
Author(s):  
E. T. Waas ◽  
T. Wobbes ◽  
R. M. L. M. Lomme ◽  
J. DeGroot ◽  
T. Ruers ◽  
...  

2018 ◽  
Vol 9 (16) ◽  
pp. 2981-2986 ◽  
Author(s):  
Yimin Shen ◽  
Caihua Wang ◽  
Yuezhong Ren ◽  
Jun Ye

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