Bone union of painful bipartite patella after treatment with low-intensity pulsed ultrasound: Report of two cases

Objective: To systematically review the role of low-intensity pulsed ultrasound on lumbar spondylolysis. Method: Literature search was conducted on PubMed, Embase, CINAHL, Web of Science, PEDro and Scopus databases to identify relevant studies published between 2010 and 2020 by using medical subject headings and applying Booleans, such as low-intensity pulsed ultrasound OR interventional ultrasound AND lumbar spine OR lumbar region AND spondylolysis OR stress fracture. Unpublished studies were hand-searched in the journals, abstracts of conferences were reviewed, and citation index was used for searching experts in the field and then contacting them for information. Studies included were the ones that had at least one of the following outcomes: bone union rate, treatment period to bone union and time to return to previous activities. Results: Of the 243 studies identified, 228(94%) were full text articles and only 2(0.8%) studies were critically appraised for qualitative synthesis based on bone union rate, treatment period to bone union, and time to return to previous activities. Conclusion: Low-intensity pulsed ultrasound was found to be effective for bone union and a useful therapy for quick return to playing sports in patients with lumbar spondylolysis. Key Words: Lumbar region, Spondylolysis, Interventional ultrasound, Systematic review.

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Influence of Ultrasound Bone Union Stimulation on Corrosion Resistance of Titanium Alloys

Solid State Phenomena ◽

10.4028/www.scientific.net/ssp.227.463 ◽

2015 ◽

Vol 227 ◽

pp. 463-466 ◽

Cited By ~ 2

Author(s):

Janusz Szewczenko ◽

Anna Zabuga ◽

Marcin Kaczmarek ◽

Marcin Basiaga ◽

Wojciech Kajzer ◽

...

Keyword(s):

Corrosion Resistance ◽

Titanium Alloys ◽

Pitting Corrosion ◽

Bone Union ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity ◽

Pitting Corrosion Resistance ◽

Modified Surface ◽

The Impact

The influence of bone union activation realized with the use of the low-intensity pulsed ultrasound (LIPUS) on degradation of titanium alloys was presented in the work. Ti6Al4V ELI and Ti6Al7Nb alloy samples of modified surface layer were used in the study. The preliminary surface treatments were: grinding, vibration machining, mechanical polishing, sandblasting and electrochemical polishing. The final procedures of the surface modification were anodization and steam sterilization. The scope of the work included the study of pitting corrosion resistance and concentration of metal ions released to the Ringer’s solution. The study was performed for the undeformed and deformed samples subjected to the influence of ultrasound. The reference samples were the samples kept in the solution and not having the impact of ultrasound. On the basis of the study it was found that the conditions for bone union stimulation by low intensity pulsed ultrasound do not initiate pitting corrosion of the titanium alloy samples, although they increase the mass of ions released from the surface to the solution.

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Faculty Opinions recommendation of Effects and Mechanisms of Low-Intensity Pulsed Ultrasound for Chronic Prostatitis and Chronic Pelvic Pain Syndrome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726483280.793536472 ◽

2017 ◽

Author(s):

Jaspreet Sandhu

Keyword(s):

Pelvic Pain ◽

Chronic Prostatitis ◽

Chronic Pelvic Pain ◽

Chronic Pelvic Pain Syndrome ◽

Pain Syndrome ◽

Pelvic Pain Syndrome ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity

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Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound

Bioactive Materials ◽

10.1016/j.bioactmat.2021.04.016 ◽

2021 ◽

Vol 6 (11) ◽

pp. 4073-4082

Author(s):

Kunzhan Cai ◽

Yilai Jiao ◽

Quan Quan ◽

Yulin Hao ◽

Jie Liu ◽

...

Keyword(s):

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity

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Development and Validation of Low-Intensity Pulsed Ultrasound Systems for Highly Controlled in vitro Cell Stimulation

Ultrasonics ◽

10.1016/j.ultras.2021.106495 ◽

2021 ◽

pp. 106495

Author(s):

F. Fontana ◽

F. Iberite ◽

A. Cafarelli ◽

A. Aliperta ◽

G. Baldi ◽

...

Keyword(s):

Pulsed Ultrasound ◽

Cell Stimulation ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity ◽

Development And Validation

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Osteocytes as main responders to low-intensity pulsed ultrasound treatment during fracture healing

Scientific Reports ◽

10.1038/s41598-021-89672-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Tatsuya Shimizu ◽

Naomasa Fujita ◽

Kiyomi Tsuji-Tamura ◽

Yoshimasa Kitagawa ◽

Toshiaki Fujisawa ◽

...

Keyword(s):

Fracture Healing ◽

Transcriptional Control ◽

Target Genes ◽

Pulsed Ultrasound ◽

Activated T Cells ◽

In Vivo Models ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity ◽

Ultrasound Stimulation

AbstractUltrasound stimulation is a type of mechanical stress, and low-intensity pulsed ultrasound (LIPUS) devices have been used clinically to promote fracture healing. However, it remains unclear which skeletal cells, in particular osteocytes or osteoblasts, primarily respond to LIPUS stimulation and how they contribute to fracture healing. To examine this, we utilized medaka, whose bone lacks osteocytes, and zebrafish, whose bone has osteocytes, as in vivo models. Fracture healing was accelerated by ultrasound stimulation in zebrafish, but not in medaka. To examine the molecular events induced by LIPUS stimulation in osteocytes, we performed RNA sequencing of a murine osteocytic cell line exposed to LIPUS. 179 genes reacted to LIPUS stimulation, and functional cluster analysis identified among them several molecular signatures related to immunity, secretion, and transcription. Notably, most of the isolated transcription-related genes were also modulated by LIPUS in vivo in zebrafish. However, expression levels of early growth response protein 1 and 2 (Egr1, 2), JunB, forkhead box Q1 (FoxQ1), and nuclear factor of activated T cells c1 (NFATc1) were not altered by LIPUS in medaka, suggesting that these genes are key transcriptional regulators of LIPUS-dependent fracture healing via osteocytes. We therefore show that bone-embedded osteocytes are necessary for LIPUS-induced promotion of fracture healing via transcriptional control of target genes, which presumably activates neighboring cells involved in fracture healing processes.

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