Comparison of the therapeutic effects of sildenafil citrate, heparin and neuropeptides in a rat model of acetic acid-induced gastric ulcer

Life Sciences ◽  
2017 ◽  
Vol 186 ◽  
pp. 102-110 ◽  
Author(s):  
Mehmet Kalayci ◽  
Mehmet Ali Kocdor ◽  
Tuncay Kuloglu ◽  
İbrahim Sahin ◽  
Mehmet Sarac ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Rat Model ◽  
Sildenafil Citrate ◽  
Therapeutic Effects

Effects of lansoprazole on the expression of VEGF and cellular proliferation in a rat model of acetic acid-induced gastric ulcer

2010 ◽  
Vol 45 (8) ◽  
pp. 846-858 ◽  
Author(s):  
Shun Kobayashi ◽  
Noriko Nakajima ◽  
Yoko Ito ◽  
Mitsuhiko Moriyama
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Rat Model ◽  
Cellular Proliferation

Protective and therapeutic effects of resveratrol on acetic acid-induced gastric ulcer

2009 ◽  
Vol 43 (6) ◽  
pp. 594-603 ◽  
Author(s):  
Ali Solmaz ◽  
Göksel Şener ◽  
Şule Çetinel ◽  
Meral Yüksel ◽  
Cumhur Yeğen ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Therapeutic Effects

scholarly journals Antichronic Gastric Ulcer Effect of Zinc-Baicalin Complex on the Acetic Acid-Induced Chronic Gastric Ulcer Rat Model

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Hui Yang ◽  
Yi Lu ◽  
Xiao-Feng Zeng ◽  
Ling Li ◽  
Rong-Ping Zhang ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Gastric Mucosa ◽  
Rat Model ◽  
Dependent Manner ◽  
Ulcer Index ◽  
Sod Activity ◽  
Zinc Gluconate ◽  
Mda Content ◽  
Anti Inflammatory

Background. Baicalin (BA) has been shown to have anti-inflammatory and antioxidant activity. Zinc is a nutrient element. Objective. This study is aimed at investigating the antichronic gastric ulcer activity of Zn-Baicalin complex (BA-Zn) and its related mechanisms in an acetic acid-induced gastric ulcer rat model. Results. The severely ulcerated gastric mucosa of model rats had lower GSH-Px (52.21 ± 7.13) and SOD (7.03 ± 0.10) activity, and higher MDA (2.39 ± 0.03) content compared to sham rats. BA-Zn reduced the gastric ulcer index in a dose-dependent manner, significantly increased SOD activity and GSH-Px level, and reduced the MDA content and IL-8 and TNF-α levels in the gastric mucosa. BA-Zn (6.5 and 13 mg/kg) exerted a greater antiulcerogenic effect than both BA and zinc-gluconate, leading to a reduced ulcer index (18.43 ± 1.11, 15.00 ± 1.44), decreased MDA content (1.33 ± 0.07, 0.63 ± 0.01), and increased SOD activity (17.62 ± 0.11, 20.12 ± 0.32) and GSH-Px levels (102.12 ± 9.11, 120.25 ± 9.07). In addition, our results from Western blot suggested that BA-Zn (6.5 and 13 mg/kg) has a greater antiulcerogenic effect than both BA and zinc-gluconate. Conclusion. The BA-Zn complex possesses greater antichronic gastric ulcer properties compared to BA and zinc-gluconate due to its ability of oxidation resistance and anti-inflammatory effects.

scholarly journals Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid

2020 ◽  
Vol 43 (2) ◽  
pp. 405-416 ◽  
Author(s):  
Gulcin Ercan ◽  
Rumeysa Ilbar Tartar ◽  
Ali Solmaz ◽  
Osman Bilgin Gulcicek ◽  
Onur Olgac Karagulle ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Therapeutic Effects

scholarly journals Accelerated Ulcer Healing and Resistance to Ulcer Recurrence with Gastroprotectants in Rat Model of Acetic Acid-induced Gastric Ulcer

2008 ◽  
Vol 42 (3) ◽  
pp. 204-214 ◽  
Author(s):  
Tae Young Oh ◽  
Byung Ok Ahn ◽  
Eun Jung Jang ◽  
Joo Sang Park ◽  
Sang Jong Park ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Rat Model ◽  
Ulcer Healing ◽  
Ulcer Recurrence

Increased expression of an amino acid transporter LAT1 in healing of acetic acid-induced chronic gastric ulcer in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A153-A153
Author(s):  
S MIYAMOTO ◽  
K KATO ◽  
Y ISHII ◽  
S ASAI ◽  
T NAGAISHI ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Amino Acid ◽  
Amino Acid Transporter ◽  
Chronic Gastric Ulcer ◽  
Acid Transporter

scholarly journals A New Symmetrical Thiazolidinedione Derivative: In Silico Design, Synthesis, and In Vivo Evaluation on a Streptozotocin- Induced Rat Model of Diabetes

Processes ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1294
Author(s):  
Samuel Álvarez-Almazán ◽  
Gabriel Navarrete-Vázquez ◽  
Itzia Irene Padilla-Martínez ◽  
José Correa-Basurto ◽  
Diana Alemán-González-Duhart ◽  
...  
Keyword(s):  
Rat Model ◽  
In Silico ◽  
Female Rats ◽  
Therapeutic Effects ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
In Vivo Evaluation ◽  
Docking Simulations ◽  
Ppar Γ

By activating PPAR-γ, thiazolidinediones normalize glucose levels in animal models of type 2 diabetes and in patients with this pathology. The aim of the present study was to analyze 219 new derivatives in silico and select the best for synthesis, to be evaluated for acute oral toxicity in female rats and for control of diabetes-related parameters in a rat model of streptozotocin-induced diabetes. The best compound was chosen based on pharmacokinetic, pharmacodynamic, and toxicological parameters obtained in silico and binding orientation observed by docking simulations on PPAR-γ. Compound 1G was synthesized by a quick and easy Knoevenagel condensation. Acute oral toxicity was found at a dose greater than 2000 mg/Kg. Compound 1G apparently produces therapeutic effects similar to those of pioglitazone, decreasing glycaemia and triglyceride levels in diabetic animals, without liver damage. Moreover, it did not cause a significant weight gain and tended to reduce polydipsia and polyphagia, while diminishing systemic inflammation related to TNF-α and IL-6. It lowered the level of endogenous antioxidant molecules such as reduced glutathione and glutathione reductase. In conclusion, 1G may be a candidate for further testing as an euglycemic agent capable of preventing the complications of diabetes.

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