Comparison of the anti-ulcer activity between the crude and bran-processed Atractylodes lancea in the rat model of gastric ulcer induced by acetic acid

Background. Baicalin (BA) has been shown to have anti-inflammatory and antioxidant activity. Zinc is a nutrient element. Objective. This study is aimed at investigating the antichronic gastric ulcer activity of Zn-Baicalin complex (BA-Zn) and its related mechanisms in an acetic acid-induced gastric ulcer rat model. Results. The severely ulcerated gastric mucosa of model rats had lower GSH-Px (52.21 ± 7.13) and SOD (7.03 ± 0.10) activity, and higher MDA (2.39 ± 0.03) content compared to sham rats. BA-Zn reduced the gastric ulcer index in a dose-dependent manner, significantly increased SOD activity and GSH-Px level, and reduced the MDA content and IL-8 and TNF-α levels in the gastric mucosa. BA-Zn (6.5 and 13 mg/kg) exerted a greater antiulcerogenic effect than both BA and zinc-gluconate, leading to a reduced ulcer index (18.43 ± 1.11, 15.00 ± 1.44), decreased MDA content (1.33 ± 0.07, 0.63 ± 0.01), and increased SOD activity (17.62 ± 0.11, 20.12 ± 0.32) and GSH-Px levels (102.12 ± 9.11, 120.25 ± 9.07). In addition, our results from Western blot suggested that BA-Zn (6.5 and 13 mg/kg) has a greater antiulcerogenic effect than both BA and zinc-gluconate. Conclusion. The BA-Zn complex possesses greater antichronic gastric ulcer properties compared to BA and zinc-gluconate due to its ability of oxidation resistance and anti-inflammatory effects.

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Accelerated Ulcer Healing and Resistance to Ulcer Recurrence with Gastroprotectants in Rat Model of Acetic Acid-induced Gastric Ulcer

Journal of Clinical Biochemistry and Nutrition ◽

10.3164/jcbn.2008030 ◽

2008 ◽

Vol 42 (3) ◽

pp. 204-214 ◽

Cited By ~ 16

Author(s):

Tae Young Oh ◽

Byung Ok Ahn ◽

Eun Jung Jang ◽

Joo Sang Park ◽

Sang Jong Park ◽

...

Keyword(s):

Acetic Acid ◽

Gastric Ulcer ◽

Rat Model ◽

Ulcer Healing ◽

Ulcer Recurrence

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Increased expression of an amino acid transporter LAT1 in healing of acetic acid-induced chronic gastric ulcer in rats

Gastroenterology ◽

10.1016/s0016-5085(01)80754-x ◽

2001 ◽

Vol 120 (5) ◽

pp. A153-A153

Author(s):

S MIYAMOTO ◽

K KATO ◽

Y ISHII ◽

S ASAI ◽

T NAGAISHI ◽

...

Keyword(s):

Acetic Acid ◽

Gastric Ulcer ◽

Amino Acid ◽

Amino Acid Transporter ◽

Chronic Gastric Ulcer ◽

Acid Transporter

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Comparison Between Omental Implantation and Omental Patch for Perforated Acetic Acid-Induced Gastric Ulcer in Rats

Wound Repair and Regeneration ◽

10.1111/j.1067-1927.2005.130116aq.x ◽

2005 ◽

Vol 13 (1) ◽

pp. A14-A14

Author(s):

Yasunori Matoba ◽

Akira Tokunaga ◽

Yukichi Moriyama ◽

Shinya Iida ◽

Norio Matsukura ◽

...

Keyword(s):

Acetic Acid ◽

Gastric Ulcer ◽

Omental Patch

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Rabbit gastric ulcer models: comparison and evaluation of acetic acid-induced ulcer and mucosectomy-induced ulcer

Laboratory Animal Research ◽

10.5625/lar.2013.29.2.96 ◽

2013 ◽

Vol 29 (2) ◽

pp. 96 ◽

Cited By ~ 3

Author(s):

Jin Hee Maeng ◽

Eunhye Lee ◽

Don Haeng Lee ◽

Su-Geun Yang

Keyword(s):

Acetic Acid ◽

Gastric Ulcer ◽

Models Comparison

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Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

Brazilian Archives of Biology and Technology ◽

10.1590/s1516-89132008000400005 ◽

2008 ◽

Vol 51 (4) ◽

pp. 479-483 ◽

Cited By ~ 1

Author(s):

Cristina Setim Freitas ◽

Cristiane Hatsuko Baggio ◽

Samanta Luiza Araújo ◽

Maria Consuelo Andrade Marques

Keyword(s):

Acetic Acid ◽

Gastric Ulcer ◽

Acute Toxicity ◽

Aqueous Extract ◽

Healing Process ◽

Intraperitoneal Administration ◽

Oral Route ◽

Chronic Gastric Ulcer ◽

Pfaffia Glomerata ◽

Tissue Healing

The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.

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