Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries

Life Sciences ◽  
2019 ◽  
Vol 221 ◽  
pp. 99-108 ◽  
Author(s):  
Forouzan Yousefi ◽  
Fahimeh Lavi Arab ◽  
Karim Nikkhah ◽  
Houshang Amiri ◽  
Mahmoud Mahmoudi
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Novel Approaches

scholarly journals Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries

2021 ◽  
Vol 6 (3) ◽  
pp. 638-654
Author(s):  
Lihua Luo ◽  
Yan He ◽  
Ling Jin ◽  
Yanni Zhang ◽  
Fernando P. Guastaldi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Peripheral Nerve ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries

Use of Stem Cells in the Regeneration of Peripheral Nerve Injuries: an Overview

2015 ◽  
Vol 3 (1) ◽  
pp. 84-98 ◽  
Author(s):  
Mohammad Bagher Ghayour ◽  
Arash Abdolmaleki ◽  
Masoud Fereidoni ◽  
◽  
◽  
...  
Keyword(s):  
Stem Cells ◽  
Peripheral Nerve ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries

The role of mesenchymal stem cells in the reconstruction of nerve injuries in the hand

2013 ◽  
Vol 154 (15) ◽  
pp. 574-580
Author(s):  
Vilmos Bíró
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Recent Literature ◽  
Experimental Studies ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Ongoing Research ◽  
Basic Characteristics ◽  
Future Direction

At present the end results of reconstruction of peripheral nerve injuries cannot be considered unequivocally advantageous. It seems that the level of reconstructive possibilities of these injuries has already peaked. Hence, ongoing research focuses on experimental studies to further improve results. One of the methods is the joint usage of pluripotent mesenchymal stem cells with tissue inductive polypeptides (growth factors) and frame structures to enhance the attachment of these cells with the aim creating new neural tissue (tissue engineering). The conditions to create new tissue can be further improved by gene technology. Based on recent literature data, the author summarizes the basic characteristics of the method related to nerve injuries, and the possibilities and modalities of clinical applications. In conclusion, future direction is a the wider use of stem cells, however, the currently established surgical and rehabilitation methods have to be performed at high levels since stem cell research data are not established in the clinical setting yet. Orv. Hetil., 2013, 154, 574–580.

scholarly journals Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiangling Li ◽  
Yanjun Guan ◽  
Chaochao Li ◽  
Tieyuan Zhang ◽  
Fanqi Meng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Immune Cells ◽  
Peripheral Nerve Injuries ◽  
Local Inflammatory Response ◽  
Inflammatory Microenvironment ◽  
Free Treatment ◽  
Immunomodulatory Potential

AbstractVarious immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesenchymal stem cells (MSCs) exhibit immunosuppressive and anti-inflammatory abilities which can accelerate tissue regeneration and attenuate inflammation, but the role of MSCs in the regulation of the local inflammatory microenvironment after PNI has not been widely studied. Here, we summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following PNI with a focus on the immunosuppressive role of MSCs. We also discuss the immunomodulatory potential of MSC-derived extracellular vesicles as a new cell-free treatment for PNI.

scholarly journals Peripheral Nerve Regeneration Using Different Germ Layer-Derived Adult Stem Cells in the Past Decade

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Yu Li ◽  
Yuzuru Kamei ◽  
Miki Kambe ◽  
Katsumi Ebisawa ◽  
Mayumi Oishi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Stem Cell ◽  
Peripheral Nerve ◽  
Adult Stem Cells ◽  
Peripheral Nerve Regeneration ◽  
Adult Stem Cell ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
The Past

Peripheral nerve injuries (PNIs) are some of the most common types of traumatic lesions affecting the nervous system. Although the peripheral nervous system has a higher regenerative ability than the central nervous system, delayed treatment is associated with disturbances in both distal sensory and functional abilities. Over the past decades, adult stem cell-based therapies for peripheral nerve injuries have drawn attention from researchers. This is because various stem cells can promote regeneration after peripheral nerve injuries by differentiating into neural-line cells, secreting various neurotrophic factors, and regulating the activity of in situ Schwann cells (SCs). This article reviewed research from the past 10 years on the role of stem cells in the repair of PNIs. We concluded that adult stem cell-based therapies promote the regeneration of PNI in various ways.

FEATURES

2012 ◽  
Vol 16 (03) ◽  
pp. 20-46
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Peripheral Nerve ◽  
Neural Stem Cells ◽  
Stem Cell Therapy ◽  
Cardiac Diseases ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries

Expatriate Researcher Returns to Roost. Past, Present and Future of Stem Cells in Regenerative Medicine. Learning Human Cardiac Diseases through Stem Cells. Bioprocessing for Stem Cell Therapy: From the Lab into the Log Phase. Neural Stem Cells and Cell-based Approaches in Neurodegeneration and Peripheral Nerve Injuries. The Marketing of Unapproved Stem Cell Products: An Industry-wide Challenge.

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