Advance investigation on synthetic small-molecule inhibitors targeting PD-1/PD-L1 signaling pathway

Life Sciences ◽  
2021 ◽  
pp. 119813
Author(s):  
Annoor Awadasseid ◽  
Yanling Wu ◽  
Wen Zhang
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Synthetic Small Molecule

DDR1 and DDR2: a review on signaling pathway and small molecule inhibitors as an anticancer agent

2021 ◽  
Vol 30 (3) ◽  
pp. 535-551
Author(s):  
Gurubasavaraja Swamy Purawarga Matada ◽  
Arka Das ◽  
Prasad Sanjay Dhiwar ◽  
Abhishek Ghara
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Anticancer Agent ◽  
Small Molecule Inhibitors

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer

2012 ◽  
Vol 35 (8) ◽  
pp. 1317-1333 ◽  
Author(s):  
Jeong In Yun ◽  
Hyoung Rae Kim ◽  
Haeil Park ◽  
Sang Kyum Kim ◽  
Jongkook Lee
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Hedgehog Signaling ◽  
Small Molecule Inhibitors ◽  
Hedgehog Signaling Pathway

Abstract 2640: Small-molecule inhibitors of CD73, CD39 and A2aR: Three anti-cancer targets in the ATP/adenosine signaling pathway

2017 ◽  
Author(s):  
Ulrike Schindler ◽  
Joanne B. Tan ◽  
Matt Walters ◽  
Annette Becker ◽  
Fangfang Yin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Anti Cancer ◽  
Adenosine Signaling

scholarly journals Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96737 ◽  
Author(s):  
David J. Rickard ◽  
Clark A. Sehon ◽  
Viera Kasparcova ◽  
Lorena A. Kallal ◽  
Pamela A. Haile ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Nucleotide Binding ◽  
Oligomerization Domain

Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action

2015 ◽  
Vol 25 (22) ◽  
pp. 5444-5448 ◽  
Author(s):  
Kyeojin Kim ◽  
Su-Jung Kim ◽  
Young Taek Han ◽  
Sung-Jun Hong ◽  
Hongchan An ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Mode Of Action ◽  
Small Molecule Inhibitors ◽  
Structural Features ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

scholarly journals The Effects of Small Molecule Inhibitors of Wnt/β-Catenin Signaling Pathway on Murine Embryonic Stem Cells.

2008 ◽  
Vol 78 (Suppl_1) ◽  
pp. 117-117
Author(s):  
Timothy McKinnon ◽  
Hong Ma ◽  
Michael Kahn
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Signaling Pathway ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells

scholarly journals Discovery of small molecule inhibitors of the PTK7/β-catenin interaction targeting the Wnt signaling pathway in colorectal cancer

2021 ◽  
Author(s):  
Laetitia Ganier ◽  
Stephane Betzi ◽  
Carine Derviaux ◽  
Philippe Roche ◽  
Christophe Muller ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Small Molecule ◽  
High Throughput Screening ◽  
Small Molecule Inhibitors ◽  
Wnt Signaling Pathway ◽  
Kinase Domain ◽  
Public Health Issue ◽  
Tyrosine Kinase Domain

Second cause of death due to cancer worldwide, colorectal cancer (CRC) is a major public health issue. The discovery of new therapeutic targets is thus essential. The pseudokinase PTK7 intervenes in the regulation of the Wnt/β-catenin pathway signaling, in part, through a kinase-domain dependent interaction with the β-catenin protein. PTK7 is overexpressed in CRC; an event associated with metastatic development and reduced survival of non-metastatic patient. In addition, numerous alterations have been identified in CRC inducing constitutive activation of Wnt/β-catenin pathway signaling through β-catenin accumulation. Thus, we thought that targeting PTK7/β-catenin interaction could be of inter-est for future drug development. In this study, we have developed a NanoBRETTM screening assay recapitulating the inter-action between PTK7 and β-catenin to identify compounds able to disrupt this protein-protein interaction. A high-throughput screening allowed us to identify small molecule inhibitors targeting the Wnt pathway signaling and inducing anti-proliferative effect in vitro in CRC cells harboring β-catenin or APC mutations downstream of PTK7. Thus, inhibition of the PTK7/β-catenin interaction could represent, in the future, a new therapeutic strategy to inhibit cell growth de-pendent on Wnt signaling pathway. Moreover, despite a lack of enzymatic activity of its tyrosine kinase domain, targeting the PTK7 kinase domain-dependent functions appears to be of interest for further therapeutic development.

ChemInform Abstract: Small-Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics

ChemInform ◽  
2011 ◽  
Vol 42 (15) ◽  
pp. no-no
Author(s):  
Jeremy L. Yap ◽  
Shilpa Worlikar ◽  
Alexander D. MacKerell ◽  
Paul Jr. Shapiro ◽  
Steven Fletcher
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Erk Signaling ◽  
Anticancer Therapeutics

scholarly journals Biochemical Suppression of Small-Molecule Inhibitors: A Strategy to Identify Inhibitor Targets and Signaling Pathway Components

2006 ◽  
Vol 13 (4) ◽  
pp. 443-452 ◽  
Author(s):  
Jeffrey R. Peterson ◽  
Andres M. Lebensohn ◽  
Henry E. Pelish ◽  
Marc W. Kirschner
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Small Molecule Inhibitors

NBBA, a synthetic small molecule, inhibits TNF-α-induced angiogenesis by suppressing the NF-κB signaling pathway

2010 ◽  
Vol 391 (3) ◽  
pp. 1500-1505 ◽  
Author(s):  
Nam Hee Kim ◽  
Hye Jin Jung ◽  
Futoshi Shibasaki ◽  
Ho Jeong Kwon
Keyword(s):  
Signaling Pathway ◽  
Small Molecule ◽  
Tnf Α ◽  
Synthetic Small Molecule
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