Gut microbiota: A potential therapeutic target for management of diabetic retinopathy?

Life Sciences ◽  
2021 ◽  
pp. 120060
Author(s):  
Rosa Elvira Alarcón Yempén ◽  
Raphaelly Venzel ◽  
Maria Clara Paulino Campos ◽  
Larissa Pessoa de Oliveira ◽  
Rodrigo Vasquez Dan Lins ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Gut Microbiota ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Wissam Zam
Keyword(s):  
Gut Microbiota ◽  
Therapeutic Target ◽  
Intestinal Microflora ◽  
Metabolic Diseases ◽  
Mutual Influence ◽  
Ayurvedic Medicine ◽  
Potential Therapeutic Target ◽  
Pharmacological Activities ◽  
Turmeric Extract ◽  
Systemic Bioavailability

Background. Turmeric is a spice that has recently received much interest and has been widely used in Ayurvedic medicine. Turmeric products are diarylheptanoids and have been characterized as safe. They are termed as curcuminoids that consists essentially of three major compounds: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcumin is a lipophilic polyphenol that has poor systemic bioavailability and suffers from biotransformation by human intestinal microflora to yield different metabolites that are easily conjugated to glucuronides and sulfate O-conjugated derivatives. Recently, an increasing number of studies have indicated that dysbiosis is linked with many metabolic diseases, though gut microbiota could be a novel potential therapeutic target. Scope and Approach. Thus, it is suspected that curcumin and its derivatives exert direct regulative effects on the gut microbiota which could explain the paradox between curcumin’s poor systemic bioavailability and its widely reported pharmacological activities. Key Findings and Conclusions. This article summarizes a range of studies that highlight the interaction between curcumin and gut microbiota and considers opportunities for microbiome-targeting therapies using turmeric extract.

Gut microbiota and probiotics intervention: A potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease?

2018 ◽  
Vol 130 ◽  
pp. 152-163 ◽  
Author(s):  
Marinaldo Pacífico Cavalcanti Neto ◽  
Jailane de Souza Aquino ◽  
Larissa de Fátima Romão da Silva ◽  
Ruanniere de Oliveira Silva ◽  
Keyth Sulamitta de Lima Guimarães ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Gut Microbiota ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Cardiometabolic Disorders

851 SQUALENE EPOXIDASE (SQLE) PROMOTES CRC VIA MODULATION OF GUT MICROBIOTA AND IS A POTENTIAL THERAPEUTIC TARGET

2020 ◽  
Vol 158 (6) ◽  
pp. S-173
Author(s):  
Chuangen Li ◽  
Dabin Liu ◽  
Chi Chun Wong ◽  
Olabisi O. Coker ◽  
Yunfei Zhou ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Therapeutic Target ◽  
Squalene Epoxidase ◽  
Potential Therapeutic Target
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