Comparative profiles of different lipoprotein cholesterol parameters and Growth Hormone during hot humid and winter season in Murrah Buffaloes

Context: GH deficiency (GHD) may occur in adults with cured acromegaly (acroGHD). Objective: Our objective was to examine the effectiveness and safety of GH replacement in acroGHD. Design: This study was a retrospective analysis of data from KIMS (Pfizer International Metabolic Database). Setting: Data were extracted from a pharmaco-epidemiological survey of >16 000 GHD adults from 31 countries. Patients: The effectiveness population included 115 adults with acroGHD and 142 age-, gender-, and body mass index-matched GHD adults with nonfunctioning pituitary adenoma (NFPA) followed up to 5 years on GH. The safety population included 164 adults with acroGHD and 2469 with NFPA, all GH-replaced. Both acroGHD and NFPA were compared with several cohorts from the general population (including the World Health Organization Global Burden of Disease). Outcome Measures: Outcome measures included quality of life (QoL-AGHDA), lipids, serious adverse events, and additional safety endpoints. Results: Median GH dose was 0.3 mg/d in acroGHD and NFPA at 5 years. There were comparable improvements in QoL-AGHDA and total and low-density lipoprotein cholesterol in acroGHD and NFPA. High-density lipoprotein cholesterol increased only in acroGHD. Cardiovascular mortality was increased in acroGHD vs NFPA (standardized mortality ratio = 3.03, P = .02). All-cause mortality was similar in acroGHD (ratio between observed/expected cases [95% confidence interval] = 1.32 [0.70–2.25]) and lower in NFPA [observed/expected = 0.58 [0.48–0.70]) in comparison with the general population. There was no difference in incidence of all cancers, benign or malignant brain tumors, or diabetes mellitus between acroGHD and NFPA. Conclusions: GH replacement has comparable effects on quality of life and lipids in acroGHD and NFPA. Further investigation is needed to examine whether the increased cardiovascular mortality may be attributed to the history of previous GH excess in acroGHD.

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The effect of growth hormone on low-density lipoprotein cholesterol and lipoprotein(a) levels in familial hypercholesterolemia

Metabolism ◽

10.1016/s0026-0495(96)90124-9 ◽

1996 ◽

Vol 45 (11) ◽

pp. 1415-1421 ◽

Cited By ~ 4

Author(s):

Serena Tonstad ◽

Elisabeth Sundt ◽

Leiv Ose ◽

Tor-Arne Hagve ◽

Jean-Charles Fruchart ◽

...

Keyword(s):

Growth Hormone ◽

Familial Hypercholesterolemia ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Lipoprotein A

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Effect of modified housing system on physiological parameters of Murrah buffaloes during autumn and winter season

Indian Journal of Animal Research ◽

10.18805/ijar.b-3305 ◽

2017 ◽

Author(s):

Amit Kumar ◽

M. L. Kamboj ◽

Subhash Chandra ◽

Pranay Bharti

Keyword(s):

Skin Temperature ◽

Respiration Rate ◽

Cortisol Level ◽

Rectal Temperature ◽

Plasma Cortisol ◽

Winter Season ◽

Plasma Cortisol Level ◽

Housing System ◽

Murrah Buffaloes ◽

Autumn And Winter

The aim of this study was to assess the effect of modified housing system on physiological parameters like rectal temperature, skin temperature, plasma cortisol level, respiration rate and pulse rate (counts/min) of Murrah buffaloes during autumn and winter seasons. A total of 14 lactating Murrah buffaloes were randomly selected and divided into two groups, on the basis of age, body weight (BW) and parity (P). T1=First group (n=7; BW=544.86kg; P=2.14) of buffaloes was housed under existing loose housing system and T2=Second group (n=7; BW=547.71kg; P=2.28) of buffaloes was housed under modified shed. In the present study, in autumn and winter season the mean rectal temperature were (T1=101.56±0.06 vs. T2=100.94±0.12ºF and T1=100.71±0.10 vs. T2=100.22±0.08ºF), skin temperature were (T1=95.19±0.61 vs. T2=93.01±0.57 ºF and T1=90.27±0.23 vs. T2=89.06±0.27 ºF) and plasma cortisol level (T1=4.04±0.23 vs. T2=3.31±0.21 and T1=3.19±0.12 vs. T2=2.70±0.14 ng/ml) respectively. These parameters were significantly (P less than 0.05) lower in buffaloes housed under T2 as compared to T1 in autumn season, respiration rate (T1=37.39±1.02 vs. T2=30.99±1.21 and T1=26.56±0.84 vs. T2=23.81±0.66 counts/min.) was significantly lower in autumn (P less than 0.01) and winter season (P less than 0.0) and pulse rate (T1=60.91±1.17 vs. T2=52.52±1.44 and T1=55.01±0.52 vs. T2=51.27±0.53 counts/min) was significantly (P less than 0.01) lower in buffaloes housed under T2 as compared to T1 in both seasons. The Murrah buffaloes housed under modified shed were improved physiological reactions during the autumn and winter seasons.

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Growth Hormone (GH) Therapy in GH-Deficient Adults Influences the Response to a Dietary Load of Cholesterol and Saturated Fat in Terms of Cholesterol Synthesis, But Not Serum Low Density Lipoprotein Cholesterol Levels

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.84.4.1296 ◽

1999 ◽

Vol 84 (4) ◽

pp. 1296-1303 ◽

Cited By ~ 2

Author(s):

M. Leonsson

Keyword(s):

Growth Hormone ◽

Cholesterol Synthesis ◽

Low Density Lipoprotein ◽

Saturated Fat ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Gh Therapy ◽

Cholesterol Levels

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Modulation of apolipoprotein A1 and B, adiponectin, ghrelin, and growth hormone concentrations by plant sterols and exercise in previously sedentary humansThis article is one of a selection of papers published in this special issue (part 1 of 2) on the Safety and Efficacy of Natural Health Products.

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y07-078 ◽

2007 ◽

Vol 85 (9) ◽

pp. 903-910 ◽

Cited By ~ 6

Author(s):

Melissa Collins ◽

Krista A. Varady ◽

Peter J.H. Jones

Keyword(s):

Growth Hormone ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plant Sterols ◽

High Density ◽

Lipoprotein Cholesterol ◽

Low Density Lipoprotein Cholesterol ◽

Cholesterol Levels

Plant sterols combined with exercise beneficially alter lipid levels in hypercholesterolemic adults. The effect of this combination therapy on other indicators of coronary heart disease risk, however, has yet to be determined. The objective of this trial was to investigate the effect of plant sterols and exercise, alone and in combination, on levels of apolipoprotein (apo) A1 and B, adiponectin, ghrelin, and growth hormone in previously sedentary hypercholesterolemic adults. In an 8 week, parallel-arm trial, 84 subjects were randomized to 1 of 4 groups: combination, exercise, plant sterols, or control. Body mass decreased by 1.1% (p < 0.01) and 0.9% (p < 0.05) in the combination and exercise group, respectively. Low-density lipoprotein cholesterol levels decreased (p < 0.01) by 0.30 mmol/L in the combination group and by 0.49 mmol/L in the plant sterol group. High-density lipoprotein cholesterol levels increased by 7.5% and 9.5% (p < 0.01) in the combination and exercise groups, respectively. Plant sterols increased (p < 0.05) adiponectin levels by 16%. No change in apoA1, apoB, ghrelin, or growth hormone levels were noted in any intervention group. ApoA1 was correlated with high-density lipoprotein cholesterol (r = 0.33, p = 0.01), whereas apoB was weakly related to low-density lipoprotein cholesterol levels (r = 0.13, p = 0.002). Adiponectin was associated with body mass index (r = –0.10, p = 0.006) and high-density lipoprotein cholesterol (r = 0.17, p = 0.0003). These findings suggest that plant sterols can increase adiponectin levels, thereby possibly reducing the risk of future coronary heart disease.

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Isolation and characterization of mastitis pathogens and milk composition changes in Murrah buffaloes (Bubalus bubalis) during winter season

Indian Journal of Animal Research ◽

10.18805/ijar.11320 ◽

2016 ◽

Author(s):

Sunita Thakur ◽

Mahendra Singh ◽

Gajendra Kumar Aseri ◽

Archana Verma ◽

Sikander S. Khan

Keyword(s):

Winter Season ◽

Subclinical Mastitis ◽

Bubalus Bubalis ◽

Milk Composition ◽

Milk Samples ◽

Murrah Buffaloes ◽

California Mastitis Test ◽

Isolation And Characterization ◽

Cell Counts ◽

Quality Of Milk

Present investigation was carried out to study the prevalence of bacterial pathogens in clinical and subclinical mastitis in buffaloes during winter season. A total of 118 Murrah buffaloes were screened using California mastitis Test (CMT). Milk samples were collected and analyzed for fat, protein, lactose, SNF, pH, Electrical conductivity (EC) and Somatic Cell Counts (SCC). Out of 118 milk samples, 60 samples (50.84%) were negative for CMT and 58 samples (49.15%) were detected positive for mastitis incidence. Milk pH and EC was significantly higher (p<0.05) in mastitis affected samples than the normal ones, however, protein, fat, SNF and lactose were lower (p<0.05). SCC ranged between 1.28-1.48 x 105 cells/ml (in normal milk samples as compared to 3.85-6.21x 105 cells/ ml (p<0.05) in mastitis milk samples. Out of 58 samples only 51 samples exhibited bacterial growth. The culturally examined and characterized samples revealed S. aureus (35.29%) as the predominant bacteria followed by S. agalactiae with an isolation rate of 25.49%. The incidence of coliforms bacteria was not detected in any of the sample cultured and examined. It was concluded that mastitis incidence adversely affect quality of milk by increasing the SCC, pH and EC of milk. Appropriate measures needs to be taken to prevent the incidence of S. aureus bacteria which was the major causative agent.

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Increased Serum Lipoprotein(a) Concentrations after Growth Hormone (GH) Treatment in Patients with Isolated GH Deficiency

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456329603300408 ◽

1996 ◽

Vol 33 (4) ◽

pp. 330-334 ◽

Cited By ~ 24

Author(s):

Domhnall J O'Halloran ◽

Gilbert Wieringa ◽

Agathocles Tsatsoulis ◽

Stephen M Shalet

Keyword(s):

Growth Hormone ◽

Gh Deficiency ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Lipoprotein ◽

Lipoprotein Cholesterol ◽

Low Density Lipoprotein Cholesterol ◽

Gh Treatment ◽

Lipoprotein A ◽

Lipid Fractions

Fourteen post-pubertal subjects (11 male, 3 female) with isolated growth hormone (GH) deficiency were treated with a low dose (0·125 U/kg for the first 4 weeks and thereafter 0·025 U/kg/week) daily sc GH injection for 1 year. Fasting blood samples were collected at entry into the study and subsequently at 3 monthly intervals for estimation of serum cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and lipoprotein(a) [Lp(a)]. Serum Lp(a) increased progressively during the treatment period (by analysis of variance) and was 41% higher at 12 months ( P < 0·02) despite the fact that five patients showed little or no change. There was no significant change in any of the other lipid fractions. These observations are of concern as Lp(a) is an independent risk factor for cardiovascular disease and should introduce a cautionary note into the enthusiastic efforts to offer GH replacement to all GH deficient adults.

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