Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia

2021 ◽  
pp. 101052
Author(s):  
Jay F. Storz ◽  
Naim M. Bautista
Keyword(s):  
Oxygen Transport ◽  
Oxygen Affinity ◽  
Altitude Acclimatization ◽  
Hemoglobin Oxygen Affinity

Microvascular oxygen transport: impact of a left-shifted dissociation curve

1992 ◽  
Vol 262 (2) ◽  
pp. H517-H522 ◽  
Author(s):  
J. C. Stein ◽  
M. L. Ellsworth
Keyword(s):  
Oxygen Transport ◽  
Striated Muscle ◽  
Oxygen Affinity ◽  
Capillary Network ◽  
Retractor Muscle ◽  
Hemodynamic Parameters ◽  
Arterial Blood ◽  
Hemoglobin Oxygen Affinity ◽  
The Impact

The impact of an increased hemoglobin oxygen affinity (decreased P50) on oxygen transport was evaluated in capillaries of the retractor muscle under nonhypoxic (FIo2 = 0.30 and 0.21) and hypoxic (FIo2 = 0.10) conditions in hamsters with normal oxygen affinity [control; P50 = 26.1 +/- 1.0 (SD) mmHg, n = 12] and in hamsters with an increased oxygen affinity [treated; P50 = 16.2 +/- 1.6 (SD) mmHg, n = 7] induced by chronic short-term administration of sodium cyanate. Using in vivo video microscopy and computer-aided image analysis, we determined oxygen saturation (SO2) and associated hemodynamic parameters in both arteriolar (n = 30 control, 18 treated) and venular (n = 25 control, 17 treated) capillaries. In response to hypoxia, systemic arterial PO2 decreased to 29.6 +/- 6.0 (SD) mmHg in control animals and 24.7 +/- 3.8 (SD) mmHg in treated animals associated with abrupt decreases in systemic arterial blood pressure and increases in respiratory rate. The decrease in SO2 across the capillary network during nonhypoxic ventilation was 13.3% SO2 for control animals and 11.0% SO2 for treated animals. During hypoxic ventilation, the decrease in SO2 was 9.1% SO2 in control animals and 8.7% SO2 in treated animals. Hemodynamic parameters were not significantly different in the two groups during hypoxia. Estimated end-capillary PO2 was significantly lower in the treated animals. These data indicate that an increased oxygen affinity does not provide an obvious advantage for oxygen transport during hypoxia at the level of the capillary network in resting striated muscle; however, such an advantage might become apparent in the presence of an increased metabolic rate or a more severe hypoxic challenge.

The effect of altered hemoglobin-oxygen affinity on oxygen transport by hemoglobin solution

1980 ◽  
Vol 28 (3) ◽  
pp. 246-251 ◽  
Author(s):  
Steven A. Gould ◽  
Arthur Rosen ◽  
Lakshman Sehgal ◽  
George Noud ◽  
Hansa Sehgal ◽  
...  
Keyword(s):  
Oxygen Transport ◽  
Oxygen Affinity ◽  
Hemoglobin Solution ◽  
Hemoglobin Oxygen Affinity

Capillary oxygen transport during severe hypoxia: role of hemoglobin oxygen affinity

1993 ◽  
Vol 75 (4) ◽  
pp. 1601-1607 ◽  
Author(s):  
J. C. Stein ◽  
M. L. Ellsworth
Keyword(s):  
Oxygen Saturation ◽  
Oxygen Transport ◽  
Oxygen Supply ◽  
Saturation Pressure ◽  
Oxygen Affinity ◽  
Severe Hypoxia ◽  
Retractor Muscle ◽  
Hemoglobin Oxygen Affinity ◽  
Term Administration

The efficacy of an increased hemoglobin oxygen affinity [decreased oxygen half-saturation pressure of hemoglobin (P50)] on capillary oxygen transport was evaluated in the hamster retractor muscle under conditions of a severely limited oxygen supply resulting from the combined effects of a 40% reduction in systemic hematocrit and hypoxic ventilation (inspired oxygen fraction 0.1). Two groups of hamsters were utilized: one with a normal oxygen affinity (untreated; P50 = 26.1 +/- 2.4 Torr) and one with an increased oxygen affinity (treated; P50 = 15.7 +/- 1.4 Torr) induced by the chronic short-term administration of sodium cyanate. Using in vivo video microscopy and image analysis techniques, we determined oxygen saturation and associated hemodynamics at both ends of the capillary network. During hypoxic ventilation, the decrease in oxygen saturation across the network was 3.6% for untreated animals compared with 9.9% for treated animals. During hypoxia, estimated end-capillary PO2 was significantly higher in the untreated animals. These data indicate that, at the capillary level, a decreased P50 is advantageous for tissue oxygenation when oxygen supply is severely compromised, because normal oxygen losses in capillaries are maintained in treated but not in untreated animals. The data are consistent with the presence of a diffusion limitation for oxygen during severe hypoxia in animals with a normal hemoglobin oxygen affinity.

scholarly journals Participation of melatonin in regulation of blood oxygen-transport function in oxidative stress induced by injection of lipopolisaccharide

2017 ◽  
Vol 63 (6) ◽  
pp. 520-526 ◽  
Author(s):  
V.V. Zinchuk ◽  
M.E. Firago
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Sulfide ◽  
Oxygen Transport ◽  
Oxygen Affinity ◽  
Nitrogen Monoxide ◽  
Blood Oxygen ◽  
Transport Function ◽  
Blood Oxygen Saturation ◽  
Sodium Hydrosulfide ◽  
Hemoglobin Oxygen Affinity

The contribution of melatonin to the regulatoin of the blood oxygen transport function was studied during oxidative stress induced by a triple injection of lipopolysaccharide (at a dose of 5 mg/kg) in conditions of erythropoietin and gasetransmitters (nitrogen monoxide, hydrogen sulfide) action. In the experimental groups, intraperitoneal injections of melatonin (5 mg/kg), erythropoietin (1000 U/kg), hydrogen sulfide donor (NaHS 5 mg/kg), and L-arginine (100 mg/kg), were performed. The use of melatonin alone or in combination with erythropoietin, sodium hydrosulfide or L-arginine led to a decrease in lipid peroxidation products and an increase in the antioxidant protection. Melatonin, during lipopolysaccharide administration, caused changes of blood oxygen transport function: blood oxygen saturation increased, hemoglobin oxygen affinity increased. The modifying effect of melatonin on the blood oxygen transport function in combination with erythropoietin and gastransmitters did not exceed the effect of melatonin alone.

scholarly journals Molecular Pathways Involved in the Development of Congenital Erythrocytosis

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1150
Author(s):  
Jana Tomc ◽  
Nataša Debeljak
Keyword(s):  
Signal Transduction ◽  
Iron Homeostasis ◽  
Molecular Mechanisms ◽  
Oxygen Affinity ◽  
Molecular Pathways ◽  
Disease Development ◽  
Post Translational Modifications ◽  
Hemoglobin Oxygen Affinity ◽  
Insight Into ◽  
Idiopathic Erythrocytosis

Patients with idiopathic erythrocytosis are directed to targeted genetic testing including nine genes involved in oxygen sensing pathway in kidneys, erythropoietin signal transduction in pre-erythrocytes and hemoglobin-oxygen affinity regulation in mature erythrocytes. However, in more than 60% of cases the genetic cause remains undiagnosed, suggesting that other genes and mechanisms must be involved in the disease development. This review aims to explore additional molecular mechanisms in recognized erythrocytosis pathways and propose new pathways associated with this rare hematological disorder. For this purpose, a comprehensive review of the literature was performed and different in silico tools were used. We identified genes involved in several mechanisms and molecular pathways, including mRNA transcriptional regulation, post-translational modifications, membrane transport, regulation of signal transduction, glucose metabolism and iron homeostasis, which have the potential to influence the main erythrocytosis-associated pathways. We provide valuable theoretical information for deeper insight into possible mechanisms of disease development. This information can be also helpful to improve the current diagnostic solutions for patients with idiopathic erythrocytosis.

scholarly journals CD73 and AMPD3 deficiency enhance metabolic performance via erythrocyte ATP that decreases hemoglobin oxygen affinity

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
William G. O’Brien III ◽  
Vladimir Berka ◽  
Ah-Lim Tsai ◽  
Zhaoyang Zhao ◽  
Cheng Chi Lee
Keyword(s):  
Oxygen Affinity ◽  
Hemoglobin Oxygen Affinity ◽  
Metabolic Performance

Features of ozone effect on oxygen-dependent processes in the blood under hypoxic conditions

2021 ◽  
Vol 20 (3) ◽  
pp. 70-76
Author(s):  
V. V. Zinchuk ◽  
E. S. Biletskaya
Keyword(s):  
Malonic Dialdehyde ◽  
Oxygen Affinity ◽  
Diene Conjugates ◽  
Physiological Factor ◽  
Sodium Hydrosulfide ◽  
Hypoxic Conditions ◽  
Hemoglobin Oxygen Affinity ◽  
Gaseous Transmitters ◽  
Dependent Processes

Introduction. Ozone is a physiological factor that can change hemoglobin oxygen affinity and the formation of gaseous transmitters (NO, H2S). The aim is to study the effect of ozone with gaseous transmitters donors on oxygen-dependent processes in the blood under hypoxic conditions in vitro. Materials and methods. Blood samples were divided into 6 groups of 3 ml each. Groups 2, 4, 5, 6 were pretreated with a deoxygenating gas mixture (5.5 % CO2; 94.5 % N2). In groups 3, 4, 5, 6, ozonized isotonic sodium chloride solution (with an ozone concentration of 6 mg/l) was added, and in groups 5 and 6, the donors of gas transmitters nitroglycerin and sodium hydrosulfide, respectively, were additionally introduced. Results. Pre-deoxygenation reduces the effect of ozone on oxygen transport in the blood. Nitroglycerin prevents this effect. The action of ozone under hypoxic conditions leads to an increase of content of NO3-/NO2- and H2S, and combination with nitroglycerin and sodium hydrosulfide increase these parameters. Deoxygenation due to ozone reduces parameters of lipid peroxidation (malonic dialdehyde, diene conjugates), retinol and α-tocopherol, and the same result in the nitroglycerin group. Conclusion. Under hypoxic conditions, a decrease in the effect of ozone on oxygen-dependent processes is reported. Nitroglycerin reduces its manifestation, while sodium hydrosulfide does not have a similar effect.

Sign in / Sign up

Export Citation Format

Share Document