<p>We report
efficient synthesis and photophysical properties of a novel fluorescent
pyridothiazole based construct by a facile methodology and its application as a
sensor for rapid, selective as well as sensitive detection of amyloid fibres.
The novel compound has exceptionally high quantum yield and sensitivity. The
fluorescence of pyridothiazole construct is completely quenched (Turn-OFF) upon
addition of cupric ions and the fluorescence is recovered on addition of
amyloidogenic peptides like A<i>β</i><sub>42
</sub>(Turn-ON). The control experiment with native and heat treated BSA
suggest that the new probe binds to beeta/<i>β</i> sheets
present in amyloid. The new probe offers direct visualization of
fluorescence ‘Turn-OFF’ ‘Turn-ON’ under long UV without the use of
sophisticated instrumentation. Hence,
a very simple, facile and cost-effective methodology for the rapid detection of
amyloid is presented and it may in all possibility pave the way for the design
of a better probe for sensing amyloids than conventional ThT.</p>