Preparation and characterization of biocomposites based on chitosan and biomimetic hydroxyapatite derived from natural phosphate rocks

Author(s):  
S. Brahimi ◽  
A. Ressler ◽  
K. Boumchedda ◽  
M. Hamidouche ◽  
A. Kenzour ◽  
...  
2016 ◽  
Vol 126 (3) ◽  
pp. 1045-1057 ◽  
Author(s):  
H. Belhouchet ◽  
F. Chouia ◽  
M. Hamidouche ◽  
A. Leriche
Keyword(s):  

2015 ◽  
Vol 281 ◽  
pp. 82-88 ◽  
Author(s):  
Bingpeng Lin ◽  
Mei Zhong ◽  
Chengdong Zheng ◽  
Lin Cao ◽  
Dengli Wang ◽  
...  

2017 ◽  
Vol 32 (3) ◽  
pp. 399-409 ◽  
Author(s):  
Zhenyu Zhong ◽  
Jun Ma

Zinc substituted hydroxyapatite/silk fibroin composite coatings were deposited on titanium substrates at room temperature by electrophoretic deposition. Microscopic characterization of the synthesized composite nanoparticles revealed that the particle size ranged 50–200 nm, which increased a little after zinc substitution. The obtained coatings maintained the phase of hydroxyapatite and they could induce fast apatite formation in simulated body fluid, indicating high bone activity. The cell culturing results showed that the biomimetic hydroxyapatite coatings could regulate adhesion, spreading, and proliferation of osteoblastic cells. Furthermore, the biological behavior of the zinc substituted hydroxyapatite coatings was found to be better than the bare titanium without coatings and hydroxyapatite coatings without zinc, increasing MC3T1-E1 cell differentiation in alkaline phosphatase expression.


2019 ◽  
Vol 9 (3) ◽  
pp. 222-235 ◽  
Author(s):  
Oumaima Jamal Eddine ◽  
Mehdi El Bouchti ◽  
Omar Cherkaoui ◽  
Hassan Hannache ◽  
Said Gmouh

New phosphate glass formulations based on Moroccan natural phosphate minerals alone or with Moroccan red clay additive (containing the P2O5-SiO2-CaO-Al2O3-MgO-Fe2O3-K2O-Na2O-TiO2 complex) have been successfully prepared by the quenching method. The chemical composition of each of the elaborated phosphate glasses was determined by X-ray fluorescence analysis (XRF). These investigated phosphate glasses have an excellent homogeneity as was verified by SEM. Their amorphous behavior was confirmed by XRD and DSC. The increase in density and glass transition temperature due to the addition of clay is believed to be related to the crosslinking of the phosphate chains. Structural investigation of these phosphate glasses was carried out using FTIR and Raman spectroscopies. The results obtained show that the composition of these glasses contains a mixture of ultraphosphate and polyphosphate structural units. The concentrations of this mixture depending on the initial composition of the glass components. A correlation between the chemical composition and the chemical durability of the investigated glasses was studied. The results showed that the dissolution rate of the glasses decreases by increasing the clay composition up to a point. This can be explained by assuming the formation of oxygen bridges and strong bonds within the various glasses.


2015 ◽  
Vol 7 (49) ◽  
pp. 27382-27390 ◽  
Author(s):  
Mukund Bahadur Koirala ◽  
Tuyen Duong Thanh Nguyen ◽  
Arunkumar Pitchaimani ◽  
Seong-O Choi ◽  
Santosh Aryal

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 241 ◽  
Author(s):  
Chunxia Gao ◽  
Ke Zhao ◽  
Liwei Lin ◽  
Jinyu Wang ◽  
Yang Liu ◽  
...  

Hydroxyapatite (HA), a typical inorganic component of bone, is a widely utilized biomaterial for bone tissue repair and regeneration due to its excellent properties. Inspired by the recent findings on the important roles of protein in biomineralization and natural structure of fish scales, keratin was chosen as a template for modulating the assembly of HA nanocrystals. A series of HA nanocrystals with different sizes were synthesized by adjusting the concentration of partially hydrolyzed keratin. The structure and compositions of the prepared HA were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Raman spectrum, and Transmission electron microscopy (TEM). Results revealed that the size of the synthesized HA nanocrystals can be controlled by adjusting the concentration of partially hydrolyzed keratin. Specifically, the size of synthesized HA decreased from 63 ± 1.5 nm to 27 ± 0.9 nm with the increasing concentration of partially hydrolyzed keratin from 0 to 0.6g. In addition, in vitro cytocompatibility of synthesized HA nanocrystals were evaluated using the MG-63 cells.


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