Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line

2022 ◽  
Vol 542 ◽  
pp. 111527
Author(s):  
Silvia Limoncella ◽  
Clara Lazzaretti ◽  
Elia Paradiso ◽  
Sara D'Alessandro ◽  
Federica Barbagallo ◽  
...  
1983 ◽  
Vol 48 (2) ◽  
pp. 377-383 ◽  
Author(s):  
E Knust ◽  
W Dietrich ◽  
B Fleckenstein ◽  
W Bodemer

2019 ◽  
Vol 26 (09) ◽  
pp. 1950058
Author(s):  
SADEQ H. LAFTA ◽  
ALI ABDULRAHMAN TAHA ◽  
MUHAMMAD M. FARHAN ◽  
SHAIMA Y. ABDULFATTAH

Nanoparticles of alpha ferric oxide ([Formula: see text]-Fe2O3) were prepared by the hydrothermal method. Structural properties of [Formula: see text]-Fe2O3 were determined by XRD, SEM and AFM measurements. The particles had a good matching with standard pattern. Average particle size was about 90[Formula: see text]nm and the distribution extended from about 20[Formula: see text]nm to 120[Formula: see text]nm. Biocompatibility study of ferric oxide nanoparticles against bacteria, parasites, tumor cell line and normal cells was determined. No antibacterial activity was observed for the concentration, of ferric oxide nanoparticles in distilled water, up to 1.5[Formula: see text]mg/ml vs. E. coli and S. aureus. Moreover, MTT assay was used to determine the cytotoxicity against parasites and cells. Intermediate cytotoxicity (53.30%) of 1.5[Formula: see text]mg/ml of prepared nanoparticles was noted against L. tropica, while weak cytotoxicity of 5.20% was observed against L. donovani at the same concentration of ferric oxide nanoparticles. On the other hand, the prepared nanoparticles revealed low cytotoxicity (47.28%) against SR tumor cell line, while no cytotoxicity was shown against lymphocytes, as a model of normal cells.


Endocrine ◽  
2008 ◽  
Vol 33 (1) ◽  
pp. 62-76 ◽  
Author(s):  
Katharina H. Ruebel ◽  
Alexey A. Leontovich ◽  
Yoshinori Tanizaki ◽  
Long Jin ◽  
Gail A. Stilling ◽  
...  

Author(s):  
Hong‑Tao Chen ◽  
Jun Zhou ◽  
You‑Ling Fan ◽  
Chun‑Liang Lei ◽  
Bao‑Jin Li ◽  
...  

1993 ◽  
Vol 53 (4) ◽  
pp. 613-620 ◽  
Author(s):  
Cornelia A. M. van den Berg-Bakker ◽  
Anne Hagemeijer ◽  
Elsa M. Franken-Postma ◽  
Vincent T. H. B. M. Smit ◽  
Peter J. K. Kuppen ◽  
...  

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