Mutations of Mycobacterium tuberculosis induced by anti-tuberculosis treatment result in metabolism changes and elevation of ethambutol resistance

2019 ◽  
Vol 72 ◽  
pp. 151-158 ◽  
Author(s):  
Lin Sun ◽  
Liqun Zhang ◽  
Ting Wang ◽  
Weiwei Jiao ◽  
Qinjing Li ◽  
...  
2020 ◽  
Vol 13 (10) ◽  
pp. 1490-1494
Author(s):  
Ersan Atahan ◽  
Suat Saribas ◽  
Mehmet Demirci ◽  
Aylin Babalık ◽  
Seher Akkus ◽  
...  

1993 ◽  
Vol 23 (1) ◽  
pp. 13-14 ◽  
Author(s):  
Javaid Khan ◽  
Najmul Islam ◽  
Nadya Ajanee ◽  
Wasim Jafri

We determined the primary and secondary resistance of isolates of M. tuberculosis to the standard anti-tuberculous drugs in Karachi (Pakistan). Primary resistance to one or more anti-tuberculous drugs was found in 17% of 123 isolates of M. tuberculosis (obtained from patients with no history of previous treatment for tuberculosis). Secondary resistance was found in 36% of 33 isolates (obtained from individuals who had received anti-tuberculous treatment in the past). The drug to which organisms were most commonly resistant was isoniazid (11% primary resistance, 30% secondary resistance). Fifteen per cent of isolates obtained from previously-studied patients showed secondary resistance to rifampicin. We discuss the importance of these findings for tuberculosis treatment and control.


Tuberculosis ◽  
2015 ◽  
Vol 95 (3) ◽  
pp. 336-342 ◽  
Author(s):  
Nguyen T.L. Hang ◽  
Shinji Maeda ◽  
Naoto Keicho ◽  
Pham H. Thuong ◽  
Hiroyoshi Endo

2012 ◽  
Vol 25 (4) ◽  
pp. 708-719 ◽  
Author(s):  
T. Cohen ◽  
P. D. van Helden ◽  
D. Wilson ◽  
C. Colijn ◽  
M. M. McLaughlin ◽  
...  

2021 ◽  
Vol 12 (2) ◽  
pp. 172-185
Author(s):  
Yetri Elisya ◽  
Adin Hakim Kurniawan ◽  
Fikri Alamysah

Tuberkulosis (TB) paru merupakan penyakit yang disebabkan oleh Mycobacterium tuberculosis yang menyerang sistem pernafasan. Di tengah-tengah kasus melonjaknya wabah virus Covid-19, pasien TB adalah pasien yang harus lebih mewaspadai diri dari wabah tersebut. GTN (Global Tuberculosis Network) menggambarkan bahwa dari 49 pasien dengan status TB, sekitar 26 pasien menderita TB kemudian terpapar Covid-19. Tujuan penelitian ini adalah untuk mengetahui Profil Pengobatan Tuberkulosis Paru Pada Pasien Rawat Inap dengan Status Riwayat Covid-19 di Rumah Sakit Umum Daerah Pasar Minggu Periode Mei 2020-Mei 2021. Metode penelitian ini adalah analisa deskriptif kuantitatif dengan metode retrospektif  yaitu dengan mengambil data primer dari rekam medik pasien. Terdapat pasien seluruhnya berjumlah 22 orang. Jenis kelamin terbanyak adalah laki-laki yaitu 12 orang (54,55%). Usia pasien terbanyak adalah >60 tahun dengan jumlah 6 orang (27,27%), dan berat badan pasien terbanyak adalah 38-54 kg dengan jumlah 11 orang (50%). Tipe penderita terbanyak adalah Pasien Baru dengan jumlah 10 orang (45,45%). Kategori pengobatan terbanyak adalah Kategori II dengan jumlah 12 orang (54,54%). Pola KDT kategori 1 paling banyak diresepkan adalah pola 3 tablet 4KDT & 3 tablet 2KDT dan 4 tablet 4KDT & 4 tablet 2KDT memiliki proporsi yang sama yaitu sebanyak 4  peresepan (18,18%). Pola KDT ketogori 2 terbanyak diresepkan adalah 3 tab 4KDT + 750mg streptomisin inj & 3 tab 2KDT + 3 tab ethambutol sebanyak 9 peresepan (40,90%). Obat-obatan untuk pasien Covid-19 yang paling sering diresepkan bersamaan dengan OAT yaitu vitamin dan mineral sebanyak 56 obat-obatan (42,42%).


2014 ◽  
Vol 11 (6) ◽  
pp. 744-752 ◽  
Author(s):  
V. Sukhithasri ◽  
Vivek Vinod ◽  
Sarath Varma ◽  
Raja Biswas

2009 ◽  
Vol 53 (7) ◽  
pp. 3170-3172 ◽  
Author(s):  
Peng Xu ◽  
Xia Li ◽  
Ming Zhao ◽  
Xiaohong Gui ◽  
Kathryn DeRiemer ◽  
...  

ABSTRACT We determined the prevalence of fluoroquinolone resistance among the isolates of Mycobacterium tuberculosis from 605 pulmonary tuberculosis patients in Shanghai, China. Mutations in gyrA were found in 81.5% of phenotypically fluoroquinolone-resistant isolates and were used as a molecular marker of fluoroquinolone resistance. gyrA mutations were detected in 1.9% of strains pan-susceptible to first-line drugs and 25.1% of multidrug-resistant strains. Fluoroquinolone resistance was independently associated with resistance to at least one first-line drug and prior tuberculosis treatment.


Tuberculosis ◽  
2021 ◽  
pp. 102082
Author(s):  
Karen Cilliers ◽  
Angela Menezes ◽  
Tariq Webber ◽  
Hazel M. Dockrell ◽  
Jacqueline M. Cliff ◽  
...  

Author(s):  
Afshan Ali Shaik ◽  
Uday Kakodkar ◽  
Cigy Borges

Introduction: Diagnosis of sputum negative pulmonary tuberculosis can be challenging and time consuming, with many patients being put on empirical anti-tuberculosis treatment. Bronchoscopy helps in early diagnosis in such patients. Aims and Objectives: To assess the diagnostic utility of bronchial washing CBNAAT for Mycobacterium Tuberculosis in sputum smear negative and sputum CBNAAT negative patients of suspected pulmonary tuberculosis. Methodology: This case series was conducted on 71 patients in the Department of Pulmonary Medicine, Goa Medical College from May 2018- February 2020. Patients with suspected pulmonary tuberculosis on chest radiograph and/or CT thorax, but with sputum smear as well as CBNAAT for Mycobacterium Tuberculosis negative were subjected to flexible video bronchoscopy. Bronchial washings were collected from the affected lobes and the specimen were subjected to fluorescent microscopy, CBNAAT, MGIT, bacterial and fungal culture. Results: The diagnosis of tuberculosis was established in 23 (32.4%) patients in bronchial washings specimen by CBNAAT. These patients were followed up after 6 months of anti-tuberculosis treatment and have shown significant clinical and radiological improvement. Conclusion: Bronchoscopy is a useful tool in diagnosis of pulmonary tuberculosis in sputum negative patients. It also play an important role in diagnosis of other infectious /malignant disorder which can mimic tuberculosis.


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