Racial difference in preterm birth and low birthweight: Towards a new hypothesis involving the interaction of 25-hydroxyvitamin D with maternal fat mass

2018 ◽  
Vol 121 ◽  
pp. 74-77
Author(s):  
Gerard Ngueta ◽  
Ruth Ndjaboue ◽  
Romuald Yepsi
Keyword(s):  
Preterm Birth ◽  
Fat Mass ◽  
Low Birthweight ◽  
Racial Difference ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
New Hypothesis

scholarly journals First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 3042 ◽  
Author(s):  
Isabelle Monier ◽  
Amandine Baptiste ◽  
Vassilis Tsatsaris ◽  
Marie-Victoire Senat ◽  
Jacques Jani ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Skin Color ◽  
First Trimester ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
First Trimester Of Pregnancy ◽  
Maternal Vitamin D Status ◽  
Multicenter Prospective Cohort

Maternal 25-hydroxyvitamin D (25-OHD) deficiency during pregnancy may increase the risk of preterm and small-for-gestational age (SGA) birth, but studies report conflicting results. We used a multicenter prospective cohort of 2813 pregnant women assessed for 25-OHD levels in the first trimester of pregnancy to investigate the association between maternal 25-OHD concentrations and risks of preterm birth (<37 weeks) and SGA (birthweight <10th percentile). Odds ratios were adjusted (aOR) for potential cofounders overall and among women with light and dark skin separately, based on the Fitzpatrick scale. 25-OHD concentrations were <20 ng/mL for 45.1% of the cohort. A total of 6.7% of women had a preterm birth. The aOR for preterm birth associated with the 1st quartile of 25-OHD concentrations compared to the 4th quartile was 1.53 (95% confidence interval (CI): 0.97–2.43). In stratified analyses, an association was observed for women with darker skin (aOR = 2.89 (95% CI: 1.02–8.18)), and no association with lighter skin. A total of 11.9% of births were SGA and there was no association overall or by skin color. Our results do not provide support for an association between maternal first trimester 25-OHD deficiency and risk of preterm or SGA birth overall; the association with preterm birth risk among women with darker skin requires further investigation.

scholarly journals Maternal 25-Hydroxyvitamin D and Preterm Birth in Twin Gestations

2013 ◽  
Vol 122 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Lisa M. Bodnar ◽  
Dwight J. Rouse ◽  
Valerija Momirova ◽  
Alan M. Peaceman ◽  
Anthony Sciscione ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency

2007 ◽  
Vol 86 (4) ◽  
pp. 959-964 ◽  
Author(s):  
Mark J Bolland ◽  
Andrew B Grey ◽  
Ruth W Ames ◽  
Barbara H Mason ◽  
Anne M Horne ◽  
...  
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Fat Mass ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Vitamin D, liver-related biomarkers, and distribution of fat and lean mass in young patients with Fontan circulation

2021 ◽  
pp. 1-8
Author(s):  
Lena Hansson ◽  
Camilla Sandberg ◽  
Inger Öhlund ◽  
Torbjörn Lind ◽  
Magne Sthen Bergdahl ◽  
...  
Keyword(s):  
Vitamin D ◽  
Fat Mass ◽  
Lean Mass ◽  
Young Patients ◽  
Fontan Circulation ◽  
Leg Pain ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Fontan Patients

Abstract Introduction/aim: Young patients with Fontan circulation may have low serum 25-hydroxyvitamin D levels, an affected liver, and unhealthy body compositions. This study aimed to explore the association between vitamin D intake/levels, liver biomarkers, and body composition in young Fontan patients. Method: We collected prospective data in 2017 to 2018, obtained with food-frequency questionnaires, biochemical analyses of liver biomarkers, and dual-energy X-ray absorptiometry scans in 44 children with Fontan circulation. Body compositions were compared to matched controls (n = 38). Linear regression analyses were used to investigate associations of biomarkers, leg pain, and lean mass on serum levels of 25-hydroxyvitamin D. Biomarkers were converted to z scores and differences were evaluated within the Fontan patients. Results: Our Fontan patients had a daily mean vitamin D intake of 9.9 µg and a mean serum 25-hydroxyvitamin D of 56 nmol/L. These factors were not associated with fat or lean mass, leg pain, or biomarkers of liver status. The Fontan patients had significantly less lean mass, but higher fat mass than controls. Male adolescents with Fontan circulation had a greater mean abdominal fat mass than male controls and higher cholesterol levels than females with Fontan circulation. Conclusion: Vitamin D intake and serum levels were not associated with body composition or liver biomarkers in the Fontan group, but the Fontan group had lower lean mass and higher fat mass than controls. The more pronounced abdominal fat mass in male adolescents with Fontan circulation might increase metabolic risks later in life.

scholarly journals Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3279
Author(s):  
Íñigo María Pérez-Castillo ◽  
Tania Rivero-Blanco ◽  
Ximena Alejandra León-Ríos ◽  
Manuela Expósito-Ruiz ◽  
María Setefilla López-Criado ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Parathyroid Hormone ◽  
Preterm Birth ◽  
Vitamin D Deficiency ◽  
Prospective Cohort ◽  
Adverse Outcomes ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Calcium And Phosphorus

Vitamin D deficiency during pregnancy has been linked to perinatal adverse outcomes. Studies conducted to date have recommended assessing interactions with other vitamin D-related metabolites to clarify this subject. We aimed to evaluate the association of vitamin D deficiency during early pregnancy with preterm birth. Secondary outcomes included low birth weight and small for gestational age. Additionally, we explored the role that parathyroid hormone, calcium and phosphorus could play in the associations. We conducted a prospective cohort study comprising 289 pregnant women in a hospital in Granada, Spain. Participants were followed-up from weeks 10–12 of gestation to postpartum. Serum 25-hydroxyvitamin D, parathyroid hormone, calcium, and phosphorus were measured within the first week after recruitment. Pearson’s χ2 test, Mann–Whitney U test, binary and multivariable logistic regression models were used to explore associations between variables and outcomes. 36.3% of the participants were vitamin D deficient (<20 ng/mL). 25-hydroxyvitamin D concentration was inversely correlated with parathyroid hormone (ρ = −0.146, p = 0.013). Preterm birth was associated with vitamin D deficiency in the multivariable model, being this association stronger amongst women with parathyroid hormone serum levels above the 80th percentile (adjusted odds ratio (aOR) = 6.587, 95% CI (2.049, 21.176), p = 0.002). Calcium and phosphorus were not associated with any studied outcome. Combined measurement of 25-hydroxyvitamin D and parathyroid hormone could be a better estimator of preterm birth than vitamin D in isolation.

scholarly journals Association between 25-Hydroxyvitamin D Status and Components of Body Composition and Glucose Metabolism in Older Men and Women

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1826 ◽  
Author(s):  
Svea-Vivica Mathieu ◽  
Karina Fischer ◽  
Bess Dawson-Hughes ◽  
Gregor Freystaetter ◽  
Felix Beuschlein ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Glucose Metabolism ◽  
Fat Mass ◽  
Lean Mass ◽  
Cell Function ◽  
Smoking Status ◽  
Community Dwelling ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Obesity and sarcopenia are major causes of morbidity and mortality among seniors. Vitamin D deficiency is very common especially among seniors and has been associated with both muscle health and obesity. This study investigated if 25-hydroxyvitamin D (25(OH)D) status is associated with body composition and insulin resistance using baseline data of a completed RCT among relatively healthy community-dwelling seniors (271 seniors age 60+ years undergoing elective surgery for unilateral total knee replacement due to osteoarthritis). Cross-sectional analysis compared appendicular lean mass index (ALMI: lean mass kg/height m2) and fat mass index (FMI: fat mass kg/height m2) assessed by DXA and insulin resistance between quartiles of serum 25(OH)D concentration using multivariable linear regression adjusted for age, sex, smoking status, physical activity, and body mass index (BMI). Participants in the lowest serum 25(OH)D quartile (4.7–17.5 ng/mL) had a higher fat mass (9.3 kg/m2) compared with participants in the third (8.40 kg/m2; Q3 = 26.1–34.8 ng/mL) and highest (8.37 kg/m2; Q4 = 34.9–62.5 ng/mL) quartile (poverall = 0.03). Higher serum 25(OH)D quartile status was associated with higher insulin sensitivity (poverall = 0.03) and better beta cell function (p = 0.004). Prevalence of insulin resistance tended to be higher in the second compared with the highest serum 25(OH)D quartile (14.6% vs. 4.8%, p = 0.06). Our findings suggest that lower serum 25(OH)D status may be associated with greater fat mass and impaired glucose metabolism, independent of BMI and other risk factors for diabetes.

scholarly journals Status of neutrophil-lymphocyte ratio and 25-hydroxyvitamin D in preeclampsia and preterm birth

2017 ◽  
Vol 25 (3) ◽  
pp. 91-96
Author(s):  
Lebriz Hale Tamer ◽  
Yeliz Aykanat ◽  
Fulya Gökdağlı Sağır ◽  
Oktay Olmuşçelik ◽  
Suna Özdemir
Keyword(s):  
Preterm Birth ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Circulating 25-Hydroxyvitamin D Concentrations in Overweight and Obese Adults Are Explained by Sun Exposure, Skin Reflectance, and Body Composition

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Brian D Piccolo ◽  
Laura M Hall ◽  
Charles B Stephensen ◽  
Erik R Gertz ◽  
Marta D Van Loan
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Regression Model ◽  
Fat Mass ◽  
Sun Exposure ◽  
Obese Adults ◽  
Hydroxyvitamin D ◽  
Skin Reflectance ◽  
25 Hydroxyvitamin D ◽  
Total Fat

ABSTRACT Background Obese individuals are known to be at higher risk for vitamin D deficiency than normal-weight individuals. Cutaneous synthesis is a major source of vitamin D; however, objective measurements of sun exposure are lacking in this population. Objective To assess the validity of a regression model using sun exposure in lean individuals to estimate serum 25-hydroxyvitamin D [25(OH)D] in overweight and obese individuals, and to develop a prediction equation for serum 25(OH)D in overweight and obese adults. Methods This study was a secondary analysis of a 15-wk controlled feeding study investigating the effects of dairy consumption on body composition. Information regarding sun exposure, including day, hour, time outside, and clothing, were self-assessed in sun exposure diaries. Personal sun exposure energy (joules) was assessed by downloading time-specific ultraviolet B energy data from climate stations. Skin reflectance was measured using a Minolta 2500d spectrophotometer. Dietary intake of vitamin D was known. Serum 25(OH)D concentration was measured by radioimmunoassay. Body composition was determined from whole-body dual energy x-ray absorptiometry and computed tomography scans. Results Sun exposure was positively related to serum 25(OH)D (r = 0.26; P ≤ 0.05) and inversely related to total fat mass, android fat, and BMI (r = −0.25, −0.30, and −0.32, respectively). The modified Hall model significantly overestimated serum 25(OH)D in overweight and obese adults by 27.33–80.98 nmol/L, depending on the sun exposure calculation. A new regression model was developed for overweight and obese persons that explained 29.1% of the variance in postintervention 25(OH)D concentrations and included sun exposure, skin reflectance, total fat mass, total lean mass, and intra-abdominal adipose tissue as predictors. Conclusion Major determinants of serum 25(OH)D concentration in healthy overweight and obese individuals include sun exposure, skin reflectance, and adiposity. Addition of adiposity terms to the prior model significantly improved predictive ability in overweight and obese men and women. (clinicaltrials.gov: NCT00858312)

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