The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency

The aim of the present study was to describe vitamin D status and seasonal variation in the general Danish population. In this study, 3092 persons aged 2 to 69 years (2565 adults, 527 children) had blood drawn twice (spring and autumn) between 2012 and 2014. A sub-sample of participants had blood samples taken monthly over a year. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by liquid chromatography mass spectrometry, and information on supplement use was assessed from questionnaires. Seasonal variations in 25(OH)D concentrations were evaluated graphically and descriptively, and status according to age, sex, and supplement use was described. It was found that 86% of both adults and children were vitamin D-sufficient in either spring and or/autumn; however, many had a spring concentration below 50 nmol/L. A wide range of 25(OH)D concentrations were found in spring and autumn, with very low and very high values in both seasons. Among adults, women in general had higher median 25(OH)D concentrations than men. Furthermore, vitamin D supplement use was substantial and affected the median concentrations markedly, more so during spring than autumn. Seasonal variation was thus found to be substantial, and bi-seasonal measurements are vital in order to capture the sizable fluctuations in vitamin D status in this Nordic population.

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Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients

British Journal Of Nutrition ◽

10.1017/s0007114599000264 ◽

1999 ◽

Vol 81 (2) ◽

pp. 133-137 ◽

Cited By ~ 30

Author(s):

Elisabetta Romagnoli ◽

Patrizia Caravella ◽

Liliana Scarnecchia ◽

Paolo Martinez ◽

Salvatore Minisola

Keyword(s):

Vitamin D ◽

Seasonal Variation ◽

Postmenopausal Women ◽

Healthy Subjects ◽

Hypovitaminosis D ◽

Hospitalized Patients ◽

Italian Population ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Group D

The present study aimed to investigate the prevalence and seasonal variation of hypovitaminosis D (defined as serum 25-hydroxyvitamin D level below 30 nmol/l) among healthy subjects and hospitalized patients living in central Italy. We studied 297 subjects, 131 in February 1997 and 166 in July 1997, subdivided into four groups: (a) young healthy blood donors; (b) healthy postmenopausal women; (c) inpatients with various medical diseases and (d) inpatients engaged in long-term rehabilitation programmes because of various neurological disorders. In all subjects and patients serum levels of 25-hydroxyvitamin D were measured by radioimmunoassay. We found a significant seasonal variation (P< 0·0001) of serum 25-hydroxyvitamin D levels, mean values being higher in summer in all groups, except in patients with a longer hospitalization time (group (d)). In each group, a significantly higher prevalence of hypovitaminosis D was found in winter compared with summer time (P< 0·001), being unexpectedly high in postmenopausal women (winter 32 % and summer 4·5 %); furthermore, in both seasons, inpatients were characterized by the highest incidences of hypovitaminosis, particularly those in group (d) (winter 82·3 % and summer 57·8 %). The results of the present study emphasize the importance of 25-hydroxyvitamin D measurement, and the need to increase vitamin D intake in Italy; foodstuff fortification and supplement use must be considered in order to prevent negative effects of vitamin D deficiency on skeletal integrity.

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Study on the relationship between serum 25-hydroxyvitamin D levels and vascular calcification in hemodialysis patients with consideration of seasonal variation in vitamin D levels

Atherosclerosis ◽

10.1016/j.atherosclerosis.2011.11.028 ◽

2012 ◽

Vol 220 (2) ◽

pp. 563-568 ◽

Cited By ~ 8

Author(s):

Jae Hyun Chang ◽

Han Ro ◽

Sejoong Kim ◽

Hyun Hee Lee ◽

Wookyung Chung ◽

...

Keyword(s):

Vitamin D ◽

Seasonal Variation ◽

Vascular Calcification ◽

Hemodialysis Patients ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Relationship

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Vitamin D, liver-related biomarkers, and distribution of fat and lean mass in young patients with Fontan circulation

Cardiology in the Young ◽

10.1017/s1047951121003115 ◽

2021 ◽

pp. 1-8

Author(s):

Lena Hansson ◽

Camilla Sandberg ◽

Inger Öhlund ◽

Torbjörn Lind ◽

Magne Sthen Bergdahl ◽

...

Keyword(s):

Vitamin D ◽

Fat Mass ◽

Lean Mass ◽

Young Patients ◽

Fontan Circulation ◽

Leg Pain ◽

Hydroxyvitamin D ◽

Vitamin D Intake ◽

25 Hydroxyvitamin D ◽

Fontan Patients

Abstract Introduction/aim: Young patients with Fontan circulation may have low serum 25-hydroxyvitamin D levels, an affected liver, and unhealthy body compositions. This study aimed to explore the association between vitamin D intake/levels, liver biomarkers, and body composition in young Fontan patients. Method: We collected prospective data in 2017 to 2018, obtained with food-frequency questionnaires, biochemical analyses of liver biomarkers, and dual-energy X-ray absorptiometry scans in 44 children with Fontan circulation. Body compositions were compared to matched controls (n = 38). Linear regression analyses were used to investigate associations of biomarkers, leg pain, and lean mass on serum levels of 25-hydroxyvitamin D. Biomarkers were converted to z scores and differences were evaluated within the Fontan patients. Results: Our Fontan patients had a daily mean vitamin D intake of 9.9 µg and a mean serum 25-hydroxyvitamin D of 56 nmol/L. These factors were not associated with fat or lean mass, leg pain, or biomarkers of liver status. The Fontan patients had significantly less lean mass, but higher fat mass than controls. Male adolescents with Fontan circulation had a greater mean abdominal fat mass than male controls and higher cholesterol levels than females with Fontan circulation. Conclusion: Vitamin D intake and serum levels were not associated with body composition or liver biomarkers in the Fontan group, but the Fontan group had lower lean mass and higher fat mass than controls. The more pronounced abdominal fat mass in male adolescents with Fontan circulation might increase metabolic risks later in life.

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Seasonal variation in vitamin D status in professional soccer players of the English Premier League

Applied Physiology Nutrition and Metabolism ◽

10.1139/h2012-037 ◽

2012 ◽

Vol 37 (4) ◽

pp. 798-802 ◽

Cited By ~ 38

Author(s):

James P. Morton ◽

Zafar Iqbal ◽

Barry Drust ◽

Darren Burgess ◽

Graeme L. Close ◽

...

Keyword(s):

Vitamin D ◽

Seasonal Variation ◽

Muscle Function ◽

Soccer Players ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Professional Soccer ◽

Premier League ◽

25 Hydroxyvitamin D ◽

English Premier League

The prevalence of seasonal variation in vitamin D status was examined in 20 FA Premier League soccer players residing at a latitude of 53°N. Serum 25-hydroxyvitamin D (25(OH)D) levels decreased (P < 0.001) between August (104.4 ± 21.1 nmol·L–1, range 68–151) and December (51.0 ± 19.0 nmol·L–1, range 22–86), such that levels for 65% of the sample were insufficient (<50 nmol·L–1) in winter. Strategies to augment vitamin D3 availability may therefore be advantageous for UK soccer players so as to maintain muscle function.

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Circulating 25-Hydroxyvitamin D Concentrations in Overweight and Obese Adults Are Explained by Sun Exposure, Skin Reflectance, and Body Composition

Current Developments in Nutrition ◽

10.1093/cdn/nzz065 ◽

2019 ◽

Vol 3 (7) ◽

Cited By ~ 3

Author(s):

Brian D Piccolo ◽

Laura M Hall ◽

Charles B Stephensen ◽

Erik R Gertz ◽

Marta D Van Loan

Keyword(s):

Vitamin D ◽

Body Composition ◽

Regression Model ◽

Fat Mass ◽

Sun Exposure ◽

Obese Adults ◽

Hydroxyvitamin D ◽

Skin Reflectance ◽

25 Hydroxyvitamin D ◽

Total Fat

ABSTRACT Background Obese individuals are known to be at higher risk for vitamin D deficiency than normal-weight individuals. Cutaneous synthesis is a major source of vitamin D; however, objective measurements of sun exposure are lacking in this population. Objective To assess the validity of a regression model using sun exposure in lean individuals to estimate serum 25-hydroxyvitamin D [25(OH)D] in overweight and obese individuals, and to develop a prediction equation for serum 25(OH)D in overweight and obese adults. Methods This study was a secondary analysis of a 15-wk controlled feeding study investigating the effects of dairy consumption on body composition. Information regarding sun exposure, including day, hour, time outside, and clothing, were self-assessed in sun exposure diaries. Personal sun exposure energy (joules) was assessed by downloading time-specific ultraviolet B energy data from climate stations. Skin reflectance was measured using a Minolta 2500d spectrophotometer. Dietary intake of vitamin D was known. Serum 25(OH)D concentration was measured by radioimmunoassay. Body composition was determined from whole-body dual energy x-ray absorptiometry and computed tomography scans. Results Sun exposure was positively related to serum 25(OH)D (r = 0.26; P ≤ 0.05) and inversely related to total fat mass, android fat, and BMI (r = −0.25, −0.30, and −0.32, respectively). The modified Hall model significantly overestimated serum 25(OH)D in overweight and obese adults by 27.33–80.98 nmol/L, depending on the sun exposure calculation. A new regression model was developed for overweight and obese persons that explained 29.1% of the variance in postintervention 25(OH)D concentrations and included sun exposure, skin reflectance, total fat mass, total lean mass, and intra-abdominal adipose tissue as predictors. Conclusion Major determinants of serum 25(OH)D concentration in healthy overweight and obese individuals include sun exposure, skin reflectance, and adiposity. Addition of adiposity terms to the prior model significantly improved predictive ability in overweight and obese men and women. (clinicaltrials.gov: NCT00858312)

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Seasonal variation of 25-Hydroxyvitamin D and indices of carbohydrate and lipid metabolism in postmenopausal women

PeerJ ◽

10.7717/peerj.11341 ◽

2021 ◽

Vol 9 ◽

pp. e11341

Author(s):

Anna Huta-Osiecka ◽

Krystian Wochna ◽

Zbigniew Kasprzak ◽

Alicja Nowak

Keyword(s):

Seasonal Variation ◽

Lipid Metabolism ◽

Postmenopausal Women ◽

Fat Mass ◽

Reference Values ◽

Seasonal Changes ◽

Fat Percentage ◽

Hydroxyvitamin D ◽

Carbohydrate And Lipid Metabolism ◽

25 Hydroxyvitamin D

Background Some studies indicate vitamin D’s significant contribution to metabolic processess. Therefore, the purpose of this study was to evaluate the level of carbohydrate and lipid metabolism indices in relation to seasonal changes in 25-hydroxyvitamin D (25(OH)D) concentration in postmenopausal women. Methods Sixteen postmenopausal women meeting health criteria and not using vitamin D supplementation were included in the study. Seasonal variation of somatic features and the serum concentration of 25(OH)D, glucose, insulin, parathormon, sclerostin and lipid profile were determined on two terms (autumn-winter). Results Comparative analysis of the variables between the study terms revealed a marked decrease in the concentration of 25(OH)D (p ≤ 0.0001), insulin (p < 0.05), insulin resistance index (HOMA-IR), (p < 0.05). The significant positive correlations of changes (Δ) between autumn and winter in 25(OH)D with body mass (p < 0.05), and fat mass (p ≤ 0.01), measured in the first study term, in the group of women with normal body mass index (BMI), and negative correlation with fat mass (p < 0.05) in women with a BMI value above the reference values, were found. The relationship analysis showed that in women with normal BMI, the decrease in 25(OH)D concentrations was greater when the body fat percentage was higher, whereas in women with a BMI value above the reference values, the higher the fat percentage, the smaller was the decrease in 25(OH)D concentration. Conclusions Seasonal changes in 25(OH)D concentration did not significantly affect the concentration of carbohydrate and lipid metabolism indices. The magnitude of decline in 25(OH)D levels depends on the fat mass. We suppose that environmental or lifestyle-related factors, e.g., nutritional behaviours, may have had more influence on metabolic indices than changes in 25(OH)D.

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Depressed Serum 25-Hydroxyvitamin D Levels Increase Hospital Stay and Alter Glucose Homeostasis in First-ever Ischemic Stroke

Current Neurovascular Research ◽

10.2174/1567202616666190924161947 ◽

2019 ◽

Vol 16 (4) ◽

pp. 340-347

Author(s):

Yuge Wang ◽

Yanqiang Wang ◽

Bingjun Zhang ◽

Yinyao Lin ◽

Sha Tan ◽

...

Keyword(s):

Vitamin D ◽

Ischemic Stroke ◽

Hospital Stay ◽

Functional Outcome ◽

Vitamin D Deficiency ◽

Glucose Homeostasis ◽

Clinical Severity ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Deficiency Group

Background and Objective: Vitamin D deficiency is internationally recognized among the potentially modifiable risk factors for ischemic cardio-cerebrovascular diseases. However, the association between vitamin D deficiency and stroke morbidity or mortality remains insufficiently known. Our aim is to investigate their relevance to 25-hydroxyvitamin D [25(OH) D] levels and clinical severity and outcome after 3 months in first-ever ischemic stroke. Methods: Retrospective analysis of 356 consecutive patients in first-ever ischemic stroke between 2013 and 2015. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome after 3 months of onset was evaluated using the modified Rankin scale (mRS). Results: Among the 356 enrolled patients, HbA1c was higher in insufficiency/deficiency group than that in the sufficiency group (6.3 ± 1.7 vs. 5.9 ± 1.1, p =0.015). The hospital stay was longer in insufficiency/deficiency group than that in the sufficiency group (11 (8-17) vs. 9.5 (7-13), p = 0.035). There was a significant inversed trend between serum 25(OH) D levels and hospital stay (OR 0.960, P = 0.031), using logistic regression. Conclusions: 25(OH)D levels are associated with glucose homeostasis, 25(OH) D contributes to increase the length of hospital stay. Low serum 25-OHD level is an independent predictor for hospital stay in first-ever ischemic stroke. Vitamin D deficiency did not predict functional outcome in the span of 3 months.

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