Effect of Tapak Liman (Elephantopus scaber L.) Plant Extract on Heart Histopathology of Diabetes Mellitus Rat (Rattus novergicus) Model

Background: Elephantopus scaber (ES) or tapak liman has been used by various ethnic groups in Indonesia and other countries as traditional medicine. Objectives: Comprehensive review of ES bioactivity is still limited, especially in the Indonesian language. Research Metodes: The writing of this article is based on a study of literature published on line and off line using several keywords Elephantopus scaber, bioactivities of Elephantopus scaber and uses of Elephantopus scaber. Results: In ethnobotany ES used wound medication, treatment of nephritis, edema, humidity, chest pain, fever, scabies, sores, coughs, tonics, fever, and bronchitis, and asthma. In China, ES leaves have been developed into "tea" to cure various diseases. The bioactivity of ES is anti-bacterial, anti-fungal, anticancer, hepatoprotective, stimulates hair growth, anti-diabetes mellitus, anti-wound, antioxidant, anti-neuroinflamation and overcoming kidney disorders. Conclusion: Deoxyelephantopin is one of the main sesquiterpenes lactones derived from ES has anti-cancer anti-cancer development. The development of ES tea as an anti-cancer needs to be further investigated because this plant is very easy to find in Indonesia. Keywords: Elephantophus scaber, anti-microbial, anti-cancer, deoxyelephantopin

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Utilization of Elephantopus scaber as traditional medicine and its bioactivity

GSC Biological and Pharmaceutical Sciences ◽

10.30574/gscbps.2021.15.1.0106 ◽

2021 ◽

Vol 15 (1) ◽

pp. 112-118

Author(s):

Marina Silalahi

Keyword(s):

Diabetes Mellitus ◽

Chest Pain ◽

Traditional Medicine ◽

Hair Growth ◽

Local Communities ◽

Anti Cancer ◽

Elephantopus Scaber ◽

Anti Fungal ◽

The Relationship ◽

Comprehensive Study

Elephantopus scaber has been used various ethnic groups in Indonesia and other countries as traditional medicine. Comprehensive study of the bioactivity of E. scaber is still limited, therefore this paper aims to explain the relationship between the use and its bioactivity. The writing of this article is based on a study of literature published online and offline used keywords E. scaber, bioactivities of E. scaber and uses of E. scaber. Ethnobotanically, E. scaber used to tread wound, nephritis, edema, chest pain, fever, scabies, sores, coughs, tonics, fever, and bronchitis, and asthma. The local communities in China, E. scaber leaves have been developed into "tea" to cure various diseases. The bioactivity of E. scaber is anti-bacterial, anti-fungal, anticancer, hepatoprotective, stimulates hair growth, anti-diabetes mellitus, anti-wound, antioxidant, and overcoming kidney disorders. Deoxyelephantopin is one of the main sesquiterpenes lactones derived from E. scaber has anti-cancer anticancer development. The development of E. scaber tea as an anti-cancer needs to be further investigated because this plant is very easy to find in Indonesia.

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Bio-assay Guided Isolation of α-Glucosidase Inhibitory Constituents from Eclipta alba

Natural Product Communications ◽

10.1177/1934578x1200700807 ◽

2012 ◽

Vol 7 (8) ◽

pp. 1934578X1200700 ◽

Cited By ~ 4

Author(s):

Deepak Kumar ◽

Raghuvir H. Gaonkar ◽

Rina Ghosh ◽

Bikas C. Pal

Keyword(s):

Diabetes Mellitus ◽

Plant Extract ◽

Quantitative Estimation ◽

Eclipta Alba ◽

Butanol Fraction ◽

Echinocystic Acid ◽

Rp Hplc ◽

Bio Assay

Eclipta alba (L.) Hassk is used traditionally in diabetes mellitus in India and the plant extract is reported to possess anti-diabetic activity. A bioactivity-guided isolation approach based on α-glucosidase inhibition was used to identify the constituents contributing towards the inhibition of the enzyme and probably contributing towards its anti-diabetic activity. Four echinocystic acid glycosides were thus isolated, of which eclalbasaponin VI, isolated from the n-butanol fraction, was found to be the most potent (IC50 54.2 ± 1.3 μM). The compound is an uncompetitive type of inhibitor with Ki 26.1 μM. A quantitative estimation of the constituents was established using RP-HPLC.

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The Effects of Plant Extract Pycnogenol® on Diabetes Mellitus Therapy: Review

Turkiye Klinikleri Journal of Pharmacy Sciences ◽

10.5336/pharmsci.2016-52868 ◽

2017 ◽

Vol 6 (1) ◽

pp. 25-31

Author(s):

Merve BACANLI ◽

Hatice Gül ANLAR ◽

Nuray ARI ◽

A. Ahmet BAŞARAN ◽

Nurşen BAŞARAN

Keyword(s):

Diabetes Mellitus ◽

Plant Extract

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Gmelina arboreaRoxb. (Family: Verbenaceae) Extract Upregulates theβ-Cell Regeneration in STZ Induced Diabetic Rats

Journal of Diabetes Research ◽

10.1155/2016/4513871 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Anoja Priyadarshani Attanayake ◽

Kamani Ayoma Perera Wijewardana Jayatilaka ◽

Chitra Pathirana ◽

Lakmini Kumari Boralugoda Mudduwa

Keyword(s):

Diabetes Mellitus ◽

Plant Extract ◽

Blood Glucose Concentration ◽

Serum Insulin ◽

Fasting Blood Glucose ◽

Treated Group ◽

Diabetic Rats ◽

Bark Extract ◽

Cell Regeneration ◽

Standard Drug

Gmelina arboreaRoxb. (common name: Et-demata, Family: Verbenaceae) has been used traditionally in Sri Lanka as a remedy against diabetes mellitus. The objective of the present study was to evaluate antidiabetic mechanisms of the aqueous bark extract ofG. arboreain streptozotocin induced (STZ) diabetic male Wistar rats. Aqueous bark extract ofG. arborea(1.00 g/kg) and glibenclamide as the standard drug (0.50 mg/kg) were administered orally using a gavage to STZ diabetic rats (65 mg/kg, ip) for 30 days. The antidiabetic mechanisms of aqueous extract ofG. arborea(1.00 g/kg) were determined at the end of the experiment. The fasting blood glucose concentration was significantly lowered and the serum insulin and C-peptide concentrations were increased by 57% and 39% in plant extract treated rats on day 30, respectively (p<0.05). The histopathology and immunohistochemistry results of the plant extract treated group showed a regenerative effect onβ-cells of the pancreas in diabetic rats. In addition, serum lipid parameters were improved inG. arboreaextract treated diabetic rats. The results revealed that the aqueous stem bark extract ofG. arborea(1.00 g/kg) showed beneficial effects against diabetes mellitus through upregulating theβ-cell regeneration and biosynthesis of insulin in diabetic rats.

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Peer Relationship Problems in Children with Tourette's Disorder or Diabetes Mellitus

Journal of Child Psychology and Psychiatry ◽

10.1017/s0021963098002480 ◽

1998 ◽

Vol 39 (5) ◽

pp. 663-668 ◽

Cited By ~ 53

Author(s):

Harry N. Bawden ◽

Aidan Stokes ◽

Carol S. Camfield ◽

Peter R. Camfield ◽

Sonia Salisbury

Keyword(s):

Diabetes Mellitus ◽

Peer Relationship ◽

Tourette’S Disorder ◽

Relationship Problems ◽

Tourette's Disorder

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Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120102 ◽

1985 ◽

Vol 43 ◽

pp. 682-683

Author(s):

Bruce R. Pachter

Keyword(s):

Diabetes Mellitus ◽

Peripheral Nerves ◽

Sudden Onset ◽

Extraocular Muscles ◽

Diabetic Patients ◽

Oculomotor Palsy ◽

Third Nerve Palsy ◽

Patients With Diabetes ◽

Intramuscular Nerve ◽

Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

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