Aluminium Administration is Associated with Biochemical Parameters Histopathological Changes in Rat Liver

Metabolism ◽  
2021 ◽  
Vol 116 ◽  
pp. 154505
Author(s):  
Demmouche Abbassia ◽  
H. Bekhadda ◽  
A.E. Menadi ◽  
D. Ferrag ◽  
Khalloua Zine Charaf ◽  
...  
Keyword(s):  
Rat Liver ◽  
Biochemical Parameters ◽  
Histopathological Changes

Chronic ethanol consumption induces histopathological changes and increases nitric oxide generation in the rat liver

2011 ◽  
Vol 43 (6) ◽  
pp. 384-391 ◽  
Author(s):  
Luis F. Tirapelli ◽  
Marcelo E. Batalhão ◽  
Ana L. Jacob-Ferreira ◽  
Daniela P. Tirapelli ◽  
Evelin C. Carnio ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Liver ◽  
Ethanol Consumption ◽  
Chronic Ethanol ◽  
Histopathological Changes ◽  
Chronic Ethanol Consumption

scholarly journals Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus

2013 ◽  
Vol 53 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Hany Kamal Abd-Elhady ◽  
Gamal Elsayed Abou-Elghar
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Corn Oil ◽  
Male Rats ◽  
Streptomyces Avermitilis ◽  
Sublethal Dose ◽  
Histopathological Changes ◽  
Albino Rat ◽  
Liver And Kidney ◽  
Sublethal Doses

Abstract Abamectin (Avermectin B1a), is a natural fermentation product derived from the soil bacterium Streptomyces avermitilis. Abamectin (Avermectin B1a) is widely used as an insecticide, acaricide, and anthelmintic. The present study assessed the effects of repeated subacute and subchronic exposure to the commercial formulation of abamectin (Vertemic, 1.8% EC) in albino male rats. The toxic effects of abamectin were studied. The various biochemical parameters and histopathological changes were noted. A stomach tube was used to orally administer sublethal doses of abamectin suspended in corn oil to the rats. The animals were divided into four groups. Rats of the group T1 were orally administered a sublethal dose of 30 mg/kg body weight (b.wt.) (1/10 LD50) three times a week for 30 days and the animals in group T2 were exposed to 10 mg/kg b.wt. (1/30 LD50) for 210 days, once a week. Two control groups (C1 and C2) were used in parallel studies, where animals were administered a corn oil vehicle. At the end of the study period, blood samples were collected from all groups to measure plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, and the levels of creatinine and urea. Also, total protein and RNA contents were determined in the liver and kidney tissues. Changes in biochemical parameters were more intense in male rats from group T2 than those reported in group T1. The levels of ALT, AST, urea and creatinine were significantly elevated in rats from group T2 when compared to the control. In group T2, a significant decrease in the levels of total protein and RNA in both the liver and kidneys was observed. Fertility was also significantly reduced in male rats ingesting abamectin in group T2. The number of offspring was significantly reduced. Histopathological changes were more intense in male rats from group T2 than those from group T1. In conclusion, the results of this study demonstrate that subchronic oral administration of abamectin altered some biochemical parameters which correlated with histopathological changes

scholarly journals Antimicrobial activity and acute and chronic toxicity of the essential oil of Lippia origanoides

2014 ◽  
Vol 34 (12) ◽  
pp. 1153-1161 ◽  
Author(s):  
Viviane A. Andrade ◽  
Anna C. Almeida ◽  
Dayane S. Souza ◽  
Keila G.F. Colen ◽  
Auricélio A. Macêdo ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Biochemical Parameters ◽  
Chronic Toxicity ◽  
Safety Margin ◽  
Toxic Effects ◽  
Histopathological Changes ◽  
Practical Application ◽  
E Coli ◽  
Hematological And Biochemical Parameters

Currently, there is a growing interest in medicinal plants, because of an increased demand for alternate therapies. In this study, the antimicrobial activity and toxicity of the essential oil of Lippia origanoides (L. origanoides) were investigated. The essential oil of L. origanoides was extracted by steam-dragging distillation and its constituents were identified by chromatography coupled with mass spectrometry. Among the 15 compounds identified, the most abundant were carvacrol (29.00%), o-cymene (25.57%), and thymol methyl ether (11.50%). The essential oil was studied in antimicrobial assays to determine the MIC and MBC. The results indicated that a concentration of 120μL/mL of oil was sufficient to inhibit the growth of the following microorganisms: Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923) and Salmonella cholerasuis (ATCC 10708). Acute and chronic toxic effects of orally administered oil were investigated in Wistar rats by using standard methods. Doses of 30, 60 and 120mg/kg of the essential oil did not induce significant changes in weight, behavior or hematological and biochemical parameters in the animals. There were no signs of any histopathological changes to the liver, kidneys or heart of the treated rats, suggesting that Lippia origanoides oil is non-toxic after oral administration in acute or chronic toxicity studies. The results obtained in this study show that the essential oil of L. origanoides has a high safety margin, with no detectable toxic effects in rats treated with doses to 120mg/kg. In addition, L. origanoides oil demonstrated potent antimicrobial activity against S. aureus, E. coli and S. cholerasuis. Based on these findings, this essential oil may have practical application as a veterinary antimicrobial.

Effect of naked and PEG-coated gold nanoparticles on histopathology and cytokines expression in rat liver and kidneys

Nanomedicine ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 289-302 ◽  
Author(s):  
Najla S Al-Harbi ◽  
Sara T Alrashood ◽  
Nikhat J Siddiqi ◽  
Maha M Arafah ◽  
Aishah Ekhzaimy ◽  
...  
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Mrna Expression ◽  
Rat Liver ◽  
Proinflammatory Cytokines ◽  
Immunological Response ◽  
Histopathological Changes ◽  
Hepatic Cells ◽  
Tnf Α

Aim: To compare the effects of 5- and 50-nm naked and PEG-coated gold nanoparticles (AuNP) on proinflammatory cytokines (IL-1β, IL-6, TNF-α) expression and histopathological changes in liver and kidneys of rats. Materials & methods: Rats were injected with different nanoparticles and sacrificed after 24 h. Results: Both 5- and 50-nm AuNPs, and 50-nm PEG-AuNPs caused granular clumping of cytoplasm, edema and hydropic dystrophy in hepatic cells. Naked AuNPs of both sizes caused mild shrinkage, whereas 50-nm PEG-AuNPs enlarged the Bowman's space and capsule. Larger nanoparticles produced more profound mRNA expression of cytokines in both the organs. Conclusion: These findings suggest the roles of particle size and coating on immunological response and histopathological changes.

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