Suggestive evidence of protective haplotype within TGF-B1 gene region in breast density utilizing fine mapping analysis

Meta Gene ◽  
2020 ◽  
Vol 23 ◽  
pp. 100631
Author(s):  
Wan Rohani Wan Taib ◽  
Nasriah Ahmad ◽  
Elinah Ali ◽  
Tengku Fatimah Murniwati Tengku Muda ◽  
Norhasiza Mat Jusoh ◽  
...  
Keyword(s):  
Breast Density ◽  
Fine Mapping ◽  
Gene Region ◽  
Suggestive Evidence ◽  
Protective Haplotype ◽  
B1 Gene ◽  
Mapping Analysis

scholarly journals MiDAS - Meaningful Immunogenetic Data at Scale

2021 ◽  
Author(s):  
Maciej Migdal ◽  
Dan Fu Ruan ◽  
William F. Forrest ◽  
Amir Horowitz ◽  
Christian Hammer
Keyword(s):  
Amino Acid ◽  
Association Analysis ◽  
Fine Mapping ◽  
Data Transformation ◽  
R Package ◽  
Evolutionary Divergence ◽  
Statistical Association ◽  
Efficient Utilization ◽  
Mapping Analysis ◽  
Transformation Functions

Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. We present MiDAS, an R package enabling statistical association analysis and using immunogenetic data transformation functions for HLA amino acid fine mapping, analysis of HLA evolutionary divergence as well as HLA-KIR interactions. MiDAS closes the gap between inference of immunogenetic variation and its efficient utilization to make meaningful discoveries.

scholarly journals HATK: HLA analysis toolkit

2020 ◽  
Author(s):  
Wanson Choi ◽  
Yang Luo ◽  
Soumya Raychaudhuri ◽  
Buhm Han
Keyword(s):  
Amino Acid ◽  
Fine Mapping ◽  
Disease Susceptibility ◽  
Human Leukocyte ◽  
Amino Acid Sequences ◽  
Hla Typing ◽  
Amino Acid Residues ◽  
Leukocyte Antigen ◽  
Mapping Analysis ◽  
Visualization Tools

Abstract Summary Fine-mapping human leukocyte antigen (HLA) genes involved in disease susceptibility to individual alleles or amino acid residues has been challenging. Using information regarding HLA alleles obtained from HLA typing, HLA imputation or HLA inference, our software expands the alleles to amino acid sequences using the most recent IMGT/HLA database and prepares a dataset suitable for fine-mapping analysis. Our software also provides useful functionalities, such as various association tests, visualization tools and nomenclature conversion. Availability and implementation https://github.com/WansonChoi/HATK.

Fine mapping analysis of HLA-DP/DQ gene clusters on chromosome 6 reveals multiple susceptibility loci for HBV infection

Amino Acids ◽  
2015 ◽  
Vol 47 (12) ◽  
pp. 2623-2634 ◽  
Author(s):  
Jingjing Tao ◽  
Kunkai Su ◽  
Chengbo Yu ◽  
Xiaoli Liu ◽  
Wei Wu ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Gene Clusters ◽  
Hbv Infection ◽  
Chromosome 6 ◽  
Susceptibility Loci ◽  
Mapping Analysis

Fine mapping of the human pentraxin gene region on chromosome 1q23

1996 ◽  
Vol 44 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Marie-Therese Walsh ◽  
A. Divane ◽  
Alexander S. Whitehead
Keyword(s):  
Fine Mapping ◽  
Gene Region

Fine mapping of the FSHD gene region orientates the rearranged fragment detected by the probe p13E-11

1993 ◽  
Vol 2 (10) ◽  
pp. 1673-1678 ◽  
Author(s):  
Tracy J. Wright ◽  
Cisca Wijmenga ◽  
Lorraine N. Clark ◽  
Rune R. Frants ◽  
Robert Williamson ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Gene Region ◽  
Fshd Gene Region

scholarly journals VEXOR: an integrative environment for prioritization of functional variants in fine-mapping analysis

2017 ◽  
Vol 33 (9) ◽  
pp. 1389-1391 ◽  
Author(s):  
Audrey Lemaçon ◽  
Charles Joly Beauparlant ◽  
Penny Soucy ◽  
Jamie Allen ◽  
Douglas Easton ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Functional Variants ◽  
Mapping Analysis

Fine-mapping analysis of the MHC region for vitiligo based on a new Han-MHC reference panel

Gene ◽  
2018 ◽  
Vol 648 ◽  
pp. 76-81 ◽  
Author(s):  
Chao Yang ◽  
Juan Wu ◽  
Xuelei Zhang ◽  
Leilei Wen ◽  
Jingying Sun ◽  
...  
Keyword(s):  
Fine Mapping ◽  
Reference Panel ◽  
Mapping Analysis
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