Age- and host-dependent control of Borna disease virus spread in the developing brains of gerbils and rats

2003 ◽  
Vol 5 (13) ◽  
pp. 1195-1204 ◽  
Author(s):  
Byeong-Jae Lee ◽  
Makiko Watanabe ◽  
Wataru Kamitani ◽  
Satoko Baba ◽  
Makiko Yamashita ◽  
...  
Keyword(s):  
Disease Virus ◽  
Virus Spread ◽  
Borna Disease Virus ◽  
Borna Disease

scholarly journals MEK-Specific Inhibitor U0126 Blocks Spread of Borna Disease Virus in Cultured Cells

2001 ◽  
Vol 75 (10) ◽  
pp. 4871-4877 ◽  
Author(s):  
Oliver Planz ◽  
Stephan Pleschka ◽  
Stephan Ludwig
Keyword(s):  
Disease Virus ◽  
Cultured Cells ◽  
Antiviral Drug ◽  
Specific Inhibitor ◽  
Host Cells ◽  
Virus Spread ◽  
Focus Formation ◽  
Borna Disease Virus ◽  
Borna Disease

ABSTRACT Borna disease virus (BDV) is a highly neurotropic virus that causes Borna disease, a virus-induced immune-mediated encephalomyelitis, in a variety of warm-blooded animals. Recent studies reported that BDV can be detected in patients with psychiatric disorders. BDV is noncytopathic, replicates in the nucleus of infected cells, and spreads intraaxonally in vivo. Upon infection of susceptible cultured cells, virus can be detected in foci. Little is known about the cellular components required for BDV replication. Here, we show that the cellular Raf/MEK/ERK signaling cascade is activated upon infection with BDV. In the presence of the MEK-specific inhibitor U0126, cells get infected with BDV; however, there is a block in virus spread to neighboring cells. The effect of the inhibitor on virus spread was still observed when the compound was added 2 h postinfection but not if treatment was initiated as late as 4 h after infection. Our results provide new insights into the BDV-host cell interaction and show that virus infection can be controlled with drugs interfering with a cellular signaling pathway. Since concentrations of the MEK inhibitor required to block BDV focus formation are not toxic for the host cells, our finding may be important with respect to antiviral drug development.

scholarly journals Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell

2015 ◽  
Vol 18 (3) ◽  
pp. 340-354 ◽  
Author(s):  
Frank Lennartz ◽  
Karen Bayer ◽  
Nadine Czerwonka ◽  
Yinghui Lu ◽  
Kristine Kehr ◽  
...  
Keyword(s):  
Disease Virus ◽  
Surface Glycoprotein ◽  
Virus Spread ◽  
Borna Disease Virus ◽  
Borna Disease

Infection of the enteric nervous system by Borna disease virus

2001 ◽  
Vol 120 (5) ◽  
pp. A328-A328
Author(s):  
H PFANNKUCHE ◽  
J RICHT ◽  
M SCHEMANN ◽  
J SEEGER ◽  
G GAEBEL
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Disease Virus ◽  
Borna Disease Virus ◽  
Borna Disease

The humoral and cellular immune response of sheep against Borna disease virus in endemic and non-endemic areas

2004 ◽  
Vol 146 (4) ◽  
pp. 159-172 ◽  
Author(s):  
D. Müller-Doblies ◽  
S. Baumann ◽  
P. Grob ◽  
A. Hülsmeier ◽  
U. Müller-Doblies ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Cellular Immune Response ◽  
Borna Disease Virus ◽  
Endemic Areas ◽  
Cellular Immune ◽  
Borna Disease

Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial

2000 ◽  
Vol 2 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Detlef E Dietrich ◽  
Liv Bode ◽  
Carsten W Spannhuth ◽  
Timo Lau ◽  
Thomas J Huber ◽  
...  
Keyword(s):  
Disease Virus ◽  
Open Trial ◽  
Borna Disease Virus ◽  
Depressive Patients ◽  
Borna Disease
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