Probiotic Lactobacillus casei activates innate immunity via NF-κB and p38 MAP kinase signaling pathways

2006 ◽  
Vol 8 (4) ◽  
pp. 994-1005 ◽  
Author(s):  
Yun-Gi Kim ◽  
Toshihisa Ohta ◽  
Takuya Takahashi ◽  
Akira Kushiro ◽  
Koji Nomoto ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Map Kinase ◽  
Signaling Pathways ◽  
Lactobacillus Casei ◽  
P38 Map Kinase ◽  
Kinase Signaling ◽  
Probiotic Lactobacillus ◽  
Map Kinase Signaling

scholarly journals Involvement of Ca2+-activated K+ channel 3.1 in hypoxia-induced pulmonary arterial hypertension and therapeutic effects of TRAM-34 in rats

2017 ◽  
Vol 37 (4) ◽  
Author(s):  
Shujin Guo ◽  
Yongchun Shen ◽  
Guangming He ◽  
Tao Wang ◽  
Dan Xu ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Map Kinase ◽  
Signaling Pathways ◽  
Vascular Remodeling ◽  
Primary Cultures ◽  
P38 Map Kinase ◽  
Therapeutic Effects ◽  
Mrna Levels ◽  
Kinase Signaling ◽  
Map Kinase Signaling

Pulmonary artery hypertension (PAH) is an incurable disease associated with the proliferation of pulmonary artery smooth muscle cells (PASMCs) and vascular remodeling. The present study examined whether TRAM-34, a highly selective blocker of calcium-activated potassium channel 3.1 (Kca3.1), can help prevent such hypertension by reducing proliferation in PASMCs. Rats were exposed to hypoxia (10% O2) for 3 weeks and treated daily with TRAM-34 intraperitoneally from the first day of hypoxia. Animals were killed and examined for vascular hypertrophy, Kca3.1 expression, and downstream signaling pathways. In addition, primary cultures of rat PASMCs were exposed to hypoxia (3% O2) or normoxia (21% O2) for 24 h in the presence of TRAM-34 or siRNA against Kca3.1. Activation of cell signaling pathways was examined using Western blot analysis. In animal experiments, hypoxia triggered significant medial hypertrophy of pulmonary arterioles and right ventricular hypertrophy, and it significantly increased pulmonary artery pressure, Kca3.1 mRNA levels and ERK/p38 MAP kinase signaling. These effects were attenuated in the presence of TRAM-34. In cell culture experiments, blocking Kca3.1 using TRAM-34 or siRNA inhibited hypoxia-induced ERK/p38 signaling. Kca3.1 may play a role in the development of PAH by activating ERK/p38 MAP kinase signaling, which may then contribute to hypoxia-induced pulmonary vascular remodeling. TRAM-34 may protect against hypoxia-induced PAH.

Rho and p38 MAP kinase signaling pathways mediate LPA-stimulated hepatic myofibroblast migration

2003 ◽  
Vol 10 (3) ◽  
pp. 352-358 ◽  
Author(s):  
Pisit Tangkijvanich ◽  
Andrew C. Melton ◽  
Chintda Santiskulvong ◽  
Hal F. Yee
Keyword(s):  
Map Kinase ◽  
Signaling Pathways ◽  
P38 Map Kinase ◽  
Kinase Signaling ◽  
Map Kinase Signaling

scholarly journals Role of p38 MAP kinase signaling pathways in storage and voiding dysfunction in mice with spinal cord injury

2019 ◽  
Vol 39 (1) ◽  
pp. 108-115
Author(s):  
Nobutaka Shimizu ◽  
Naoki Wada ◽  
Takahiro Shimizu ◽  
Takahisa Suzuki ◽  
Masahiro Kurobe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Map Kinase ◽  
Signaling Pathways ◽  
Voiding Dysfunction ◽  
P38 Map Kinase ◽  
Kinase Signaling ◽  
Cord Injury ◽  
Map Kinase Signaling

Role of NF-κB and p38 MAP Kinase Signaling Pathways in the Lipopolysaccharide-Dependent Activation of Heme Oxygenase-1 Gene Expression

2004 ◽  
Vol 6 (5) ◽  
pp. 802-810 ◽  
Author(s):  
Nastiti Wijayanti ◽  
Sebastian Huber ◽  
Anatoly Samoylenko ◽  
Thomas Kietzmann ◽  
Stephan Immenschuh
Keyword(s):  
Gene Expression ◽  
Map Kinase ◽  
Signaling Pathways ◽  
Heme Oxygenase ◽  
P38 Map Kinase ◽  
Heme Oxygenase 1 ◽  
Kinase Signaling ◽  
Map Kinase Signaling

Role of NF-kB and p38 MAP Kinase Signaling Pathways in the Lipopolysaccharide-Dependent Activation of Heme Oxygenase-1 Gene Expression

2004 ◽  
Vol 6 (5) ◽  
pp. 802-810 ◽  
Author(s):  
Nastiti Wijayanti ◽  
Sebastian Huber ◽  
Anatoly Samoylenko ◽  
Thomas Kietzmann ◽  
Stephan Immenschuh
Keyword(s):  
Gene Expression ◽  
Map Kinase ◽  
Signaling Pathways ◽  
Heme Oxygenase ◽  
P38 Map Kinase ◽  
Heme Oxygenase 1 ◽  
Kinase Signaling ◽  
Map Kinase Signaling

Boswellia serrata oleo-gum-resin and β-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-кB and p38 MAP kinase signaling

Phytomedicine ◽  
2018 ◽  
Vol 51 ◽  
pp. 94-103 ◽  
Author(s):  
Debayan Goswami ◽  
Ananya Das Mahapatra ◽  
Subhadip Banerjee ◽  
Amit Kar ◽  
Durbadal Ojha ◽  
...  
Keyword(s):  
Map Kinase ◽  
P38 Map Kinase ◽  
Kinase Signaling ◽  
Boswellic Acid ◽  
Boswellia Serrata ◽  
Map Kinase Signaling ◽  
Hsv 1
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