The impact of comparative genomics on infectious disease research

2006 ◽  
Vol 8 (6) ◽  
pp. 1613-1622 ◽  
Author(s):  
Ren Zhang ◽  
Chun-Ting Zhang
2020 ◽  
Author(s):  
Jose Loaiza ◽  
Robinson Zapata ◽  
Rao Kosagisharaf ◽  
Rolando A. Gittens ◽  
Enrique Mendoza ◽  
...  

Abstract Background: This work aims to analyze the landscape of scientific publications on subjects related to One Health and infectious diseases in Panama. Methods: Boolean searches on the Web of Science, SCOPUS and PubMed were undertaken to evaluate the main trends of publications related to One Health and infectious disease research in the country of Panama, between 1990 and 2019. Results: 4,547 publications were identified since 1990, including 3,564 peer-reviewed articles interconnected with One Health related descriptors, and 211 articles focused particularly on infectious diseases. There was a pattern of exponential growth in the number of publications with various contributions from Panamanian institutions. The rates of multidisciplinary, inter-institutional and inter-sectoral research ranged from moderate to low, to very low, respectively. Research efforts have centered largely on protozoan, neglected and arthropod-borne diseases with a strong emphasis on malaria, Chagas and leishmaniasis. Conclusion: Panama has scientific capabilities on One Health to tackle future infectious disease threats, but the official collaboration schemes and strategic investment to develop further competencies need to be considered. Through future collaborative efforts, Panama can reduce the risk of pandemics by developing surveillance strategies to improve the prediction of disease spillover, spread and persistence while helping to mitigate the impact on public health and the economy, regionally.


2020 ◽  
Author(s):  
Jose Loaiza ◽  
Robinson Zapata ◽  
Rao Kosagisharaf ◽  
Rolando A. Gittens ◽  
Enrique Mendoza ◽  
...  

Abstract Background: This work aims to analyze the landscape of scientific publications on subjects related to One Health and infectious diseases in Panama. We asked the following specific questions: How does the One Health research landscape look like in Panama? Are historical research efforts aligned with the One Health concept? What infectious diseases have received more attention from the local scientific community since 1990?Methods: Boolean searches on the Web of Science, SCOPUS and PubMed were undertaken to evaluate the main trends of publications related to One Health and infectious disease research in the country of Panama, between 1990 and 2019. Results: 4,547 publications were identified since 1990, including 3,564 peer-reviewed articles interconnected with One Health related descriptors, and 211 articles focused particularly on infectious diseases. There was a pattern of exponential growth in the number of publications with various contributions from Panamanian institutions. The rates of multidisciplinary, inter-institutional and inter-sectoral research ranged from moderate to low, to very low, respectively. Research efforts have centered largely on protozoan, neglected and arthropod-borne diseases with a strong emphasis on malaria, Chagas and leishmaniasis. Conclusion: Panama has scientific capabilities on One Health to tackle future infectious disease threats, but the official collaboration schemes and strategic investment to develop further competencies need to be considered. Through future collaborative efforts, Panama can reduce the risk of pandemics by developing surveillance strategies to improve the prediction of disease spillover, spread and persistence while helping to mitigate the impact on public health and the economy, regionally.


2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Hee-Gyeong Yi ◽  
Hyeonji Kim ◽  
Junyoung Kwon ◽  
Yeong-Jin Choi ◽  
Jinah Jang ◽  
...  

AbstractRapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.


2015 ◽  
Vol 3 ◽  
Author(s):  
James C. Bartholomew ◽  
Andrew D. Pearson ◽  
Nils Chr. Stenseth ◽  
James W. LeDuc ◽  
David L. Hirschberg ◽  
...  

Science ◽  
2015 ◽  
Vol 349 (6252) ◽  
pp. 1259504-1259504 ◽  
Author(s):  
P. T. J. Johnson ◽  
J. C. de Roode ◽  
A. Fenton

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