A time-series ecological study protocol to analyze trends of incidence, mortality, lethality of COVID-19 in Brazil

Introduction: Since the first case of COVID-19 was confirmed in February 2020, Brazil has reported more than 20 million cases and more than 600,000 deaths on October 31, 2021. The behavior of the pandemic was also different in the various regions of the country, from those with less economic development to those with greater economic development, such as the state of São Paulo. Objective: to describe step-by-step time series for analyzing trends in mortality, lethality and incidence of COVID-19 in Brazil. Methods: a protocol for an ecological study of time series, covering the 26 states and the federal district (Brasilia). Results: The descriptions have the potential to provide information for the government and society in decision-making, about knowledge and conduct, clinical, epidemiological and research investments in health care for the Brazilian people. It is focused on fully understanding the spread of SARS-COV-2 infection in the Brazilian territory, and developing a database for public and universal access for comparative studies between countries and continents. Conclusion: database built from ecological studies are essential for a full understanding of the virus behavior, its transmissibility, lethality and mortality, and a repository for data that’s been collected and integrated from multiple sources. It is a relevant tool for the search of information and decision-making in global health.

A Pilot of a Sustainability-Extending Intervention in Canadian Nursing Homes

Understanding of intervention sustainability processes is limited. Failure to sustain evidence-based innovations means that intended improvements are short-lived, scale-up and spread are unlikely, and real losses are incurred on research investments. We explored the sustainability of a health care aide (HCA)-led quality improvement (QI) initiative, Safer Care for Older Persons (in residential) Environments (SCOPE), that was implemented in long-term care homes (LTCHs) in Manitoba, Canada. Based on our understanding of factors influencing post-implementation sustainability processes, we developed and piloted a “low-dose” and “high-dose” “Booster” intervention to extend the two-year post-implementation period over which SCOPE was naturally sustained. Both versions of the “Booster” involved the following components: a HCA-led team with management support, a workshop to review SCOPE QI approaches and tools, a binder of QI resources, and supports from an experienced Quality Advisor (QA). We collected data from various sources to depict the most accurate account of QI sustainability and conducted thematic analysis to understand each team’s experience with sustainability processes. We used a qualitative assessment rubric to evaluate the impact of the “Booster” conditions on the teams’ performance against core SCOPE components. Our results suggest that the “Booster” served to establish more relaxed expectations and generally renew interest in LTCH QI initiatives. The calibre of management support was associated with teams’ performance and management support varied with the level of QA support. These pilot results will inform the next study phase, which examines longer-term sustainability of QI initiatives in LTCHs beyond the initial 2-year post-implementation period.

Waiving COVID-19 Vaccine Patents: A Bad Idea and a Dangerous Precedent

The Biden Administration believes that suspending COVID-19 vaccine patents will expedite the swift development of high quality “cheap” versions of existing vaccines and hasten the pandemic’s end. This view is dangerously wrong. Vaccinating the world is essential, but temporarily waiving patent rights for COVID-19 vaccines (also known as “compulsory licensing”) will actually slow their availability to the developing world. While providing no gain, compulsory licensing promises lots of pain. Waiving patent protection discourages cutting-edge research investments, which in turn produce breakthrough treatments not just for COVID-19, but for other diseases, like cancer. Weakening these protections would be anti-patient and counterproductive. The reality is that, in order to save the world, we must all work together as partners. The remarkable speed with which we developed diagnostics, therapeutics, and vaccines to combat COVID-19 points to the need for more collaboration, not less. Patents are a foundational principle upon which that success rests. While the policy of temporarily waiving patents seems fair and humanitarian, the devil is in the details. Such a policy will not result in a single citizen of the developing world getting vaccinated one minute sooner. In fact, the unintended consequences are the reverse. More confusion, lower quality, less transnational cooperation. A triple play of disastrous global proportions.

Tsunami-Related Data: A Review of Available Repositories Used in Scientific Literature

Various organizations and institutions store large volumes of tsunami-related data, whose availability and quality should benefit society, as it improves decision making before the tsunami occurrence, during the tsunami impact, and when coping with the aftermath. However, the existing digital ecosystem surrounding tsunami research prevents us from extracting the maximum benefit from our research investments. The main objective of this study is to explore the field of data repositories providing secondary data associated with tsunami research and analyze the current situation. We analyze the mutual interconnections of references in scientific studies published in the Web of Science database, governmental bodies, commercial organizations, and research agencies. A set of criteria was used to evaluate content and searchability. We identified 60 data repositories with records used in tsunami research. The heterogeneity of data formats, deactivated or nonfunctional web pages, the generality of data repositories, or poor dataset arrangement represent the most significant weak points. We outline the potential contribution of ontology engineering as an example of computer science methods that enable improvements in tsunami-related data management.

Protocol for a scoping review of research on abortion in sub-Saharan Africa

Introduction Unsafe abortion is a leading cause of maternal mortality, and access to safe abortion services remains a public health priority in sub-Saharan Africa (SSA). A considerable amount of abortion research exists in the region; however, the spread of existing evidence is uneven such that some countries have an acute shortage of data with others over-researched. The imbalance reflects the complexities in prioritization among researchers, academics, and funders, and undeniably impedes effective policy and advocacy efforts. This scoping review aims to identify and map the landscape of abortion research in SSA, summarize existing knowledge, and pinpoint significant gaps, both substantive and geographic, requiring further investigation. This review will provide direction for future research, investments, and offer guidance for policy and programming on safe abortion. Materials and methods We utilize the Joanna Briggs Institute’s methodology for conducting scoping reviews. We will perform the search for articles in 8 electronic databases (i.e., PubMed, AJOL, Science Direct, SCOPUS, HINARI, Web of Knowledge, CINAHL, and WHO Regional Databases). We will include studies written in English or French language, produced or published between January 1, 2011, and July 31, 2021, and pertain directly to the subject of abortion in SSA. Using a tailored extraction frame, we will extract relevant information from publications that meet the inclusion criteria. Data will be analyzed using descriptive statistics and thematic analysis in response to key review questions. Ethics and dissemination Formal ethical approval is not required, as no primary data will be collected. The findings of this study will be disseminated through peer-reviewed publications and conference presentations.

Mapping Research Agendas in U.S. Corporate AI Laboratories

Leading U.S. companies are investing in the broad research field of artificial intelligence (AI), but where, specifically, are they making these investments? This data brief provides an analysis of the research papers published by Amazon, Apple, Facebook, Google, IBM, and Microsoft over the past decade to better understand what work their labs are prioritizing, and the degree to which these companies have similar or different research agendas overall. The authors find that major “AI companies” are often focused on very different subfields within AI, and that the private sector may be failing to make research investments consistent with ensuring long-term national competitiveness.

Mutation hotspots, geographical and temporal distribution of SARS-CoV-2 lineages in Brazil, February 2020 to February 2021: insights and limitations from uneven sequencing efforts

The COVID-19 pandemic has already reached approximately 110 million people and it is associated with 2.5 million deaths worldwide. Brazil is the third worst-hit country, with approximately 10.2 million cases and 250 thousand deaths. International efforts have been established to share information about SARS-CoV-2 epidemiology and evolution. However, sequencing facilities and research investments are very heterogeneous across different regions and countries. The understanding of the SARS-CoV-2 evolution plays a significant role in the development of effective strategies for public health and disease management. We aimed to analyze the available and high-quality genome sequences from Brazil between February 2020 and February 2021 to identify mutation hotspots, geographical and temporal distribution of SARS-CoV-2 lineages by using phylogenetics and phylodynamics analyses. We describe heterogeneous and episodic sequencing efforts, the progression of the different lineages along time, evaluating mutational spectra and frequency oscillations derived from the prevalence of novel and specific lineages across different Brazilian regions. We found at least seven major (1-7) and two minor clades (4.2 and 5.3) related to the six most prevalent lineages in the country and described its spatial distribution and dynamics. The emergence and recent frequency shift of lineages (P.1 and P.2) containing mutations of concern in the spike protein (e. g., E484K, N501Y) draws attention due to their association with immune evasion and enhanced receptor binding affinity. Improvements in genomic surveillance are of paramount importance and should be extended in Brazil to better inform policy makers and enable evidence-based decisions to fight the COVID-19 pandemic.

Seawater Electrolysis for Hydrogen Production: A Solution Looking for a Problem?

As the price of renewable electricity continues to plummet, hydrogen (H₂) production via water electrolysis is gaining momentum globally as a route to decarbonize our energy systems. The requirement of high purity water for electrolysis as well as the widespread availability of seawater have led significant research efforts in developing direct seawater electrolysis technology for H₂ production. In this Perspective, we critically assess the broad-brush arguments on the research and development (R&D) needs for direct seawater electrolysis from energy, cost and environmental aspects. We focus in particular on a process consisting of sea water reverse osmosis (SWRO) coupled to proton exchange membrane (PEM) electrolysis. Our analysis reveals there are limited economic and environmental incentives of pursuing R&D on today’s nascent direct seawater electrolysis technology. As commercial water electrolysis requires significant amount of energy compared to SWRO, the capital and operating costs of SWRO are found to be negligible. This leads to an insignificant increase in levelized cost of H₂ (<0.1 $/kg H₂) and CO₂ emissions (<0.1%) from a SWRO-PEM coupled process. Our analysis poses the questions: what is the future promise of direct seawater electrolysis? With an urgent need to decarbonize our energy systems, should we consider realigning our research investments? We conclude with a forward-looking perspective on future R&D priorities in desalination and electrolysis technologies.

Seawater Electrolysis for Hydrogen Production: A Solution Looking for a Problem?

As the price of renewable electricity continues to plummet, hydrogen (H₂) production via water electrolysis is gaining momentum globally as a route to decarbonize our energy systems. The requirement of high purity water for electrolysis as well as the widespread availability of seawater have led significant research efforts in developing direct seawater electrolysis technology for H₂ production. In this Perspective, we critically assess the broad-brush arguments on the research and development (R&D) needs for direct seawater electrolysis from energy, cost and environmental aspects. We focus in particular on a process consisting of sea water reverse osmosis (SWRO) coupled to proton exchange membrane (PEM) electrolysis. Our analysis reveals there are limited economic and environmental incentives of pursuing R&D on today’s nascent direct seawater electrolysis technology. As commercial water electrolysis requires significant amount of energy compared to SWRO, the capital and operating costs of SWRO are found to be negligible. This leads to an insignificant increase in levelized cost of H₂ (<0.1 $/kg H₂) and CO₂ emissions (<0.1%) from a SWRO-PEM coupled process. Our analysis poses the questions: what is the future promise of direct seawater electrolysis? With an urgent need to decarbonize our energy systems, should we consider realigning our research investments? We conclude with a forward-looking perspective on future R&D priorities in desalination and electrolysis technologies.

4D Printing: Materials, Technologies, and Future Applications in the Biomedical Field

4D printing can be defined as the fabrication of structures using smart materials that allow the final object to change its shape, properties, or function in response to an external stimulus such as light, heat, or moisture. The available technologies, materials, and applications have evolved significantly since their first development in 2013, with prospective applications within the aerospace, manufacturing, and soft robotic industries. This review focuses on the printing technologies and smart materials currently available for fabricating these structures. The applications of 4D printing within biomedicine are explored with a focus on tissue engineering, drug delivery, and artificial organs. Finally, some ideas for potential uses are proposed. 4D printing is making its mark with seemingly unlimited potential applications, however, its use in mainstream medical treatments relies on further developments and extensive research investments.