Toxoplasma gondii mitogen-activated protein kinases are associated with inflammasome activation in infected mice

2016 ◽  
Vol 18 (11) ◽  
pp. 696-700 ◽  
Author(s):  
Shuchao Wang ◽  
Zedong Wang ◽  
Yi Gu ◽  
Zhongyu Li ◽  
Zhongyuan Li ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Protein Kinases ◽  
Inflammasome Activation ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

scholarly journals The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases

2021 ◽  
Vol 22 (17) ◽  
pp. 9640
Author(s):  
Jing Chen ◽  
Chao Ye ◽  
Chao Wan ◽  
Gang Li ◽  
Lianci Peng ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Infectious Diseases ◽  
Protein Kinases ◽  
Therapeutic Agents ◽  
Inflammasome Activation ◽  
Mitogen Activated Protein Kinases ◽  
Jnk Signaling ◽  
Cellular Processes ◽  
Prevention And Treatment ◽  
Mitogen Activated Protein

c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; hence, JNKs may play important roles in infectious diseases. In this review, we describe the basic signaling properties of MAPKs and JNKs in apoptosis, autophagy, and inflammasome activation. Furthermore, we discuss the roles of JNKs in various infectious diseases induced by viruses, bacteria, fungi, and parasites, as well as their potential to serve as targets for the development of therapeutic agents for infectious diseases. We expect this review to expand our understanding of the JNK signaling pathway’s role in infectious diseases and provide important clues for the prevention and treatment of infectious diseases.

Sign in / Sign up

Export Citation Format

Share Document