scholarly journals The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases

2021 ◽  
Vol 22 (17) ◽  
pp. 9640
Author(s):  
Jing Chen ◽  
Chao Ye ◽  
Chao Wan ◽  
Gang Li ◽  
Lianci Peng ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Infectious Diseases ◽  
Protein Kinases ◽  
Therapeutic Agents ◽  
Inflammasome Activation ◽  
Mitogen Activated Protein Kinases ◽  
Jnk Signaling ◽  
Cellular Processes ◽  
Prevention And Treatment ◽  
Mitogen Activated Protein

c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; hence, JNKs may play important roles in infectious diseases. In this review, we describe the basic signaling properties of MAPKs and JNKs in apoptosis, autophagy, and inflammasome activation. Furthermore, we discuss the roles of JNKs in various infectious diseases induced by viruses, bacteria, fungi, and parasites, as well as their potential to serve as targets for the development of therapeutic agents for infectious diseases. We expect this review to expand our understanding of the JNK signaling pathway’s role in infectious diseases and provide important clues for the prevention and treatment of infectious diseases.

scholarly journals Dusp-5 and Snrk-1 coordinately function during vascular development and disease

Blood ◽  
2009 ◽  
Vol 113 (5) ◽  
pp. 1184-1191 ◽  
Author(s):  
Kallal Pramanik ◽  
Chang Zoon Chun ◽  
Maija K. Garnaas ◽  
Ganesh V. Samant ◽  
Keguo Li ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Vascular Development ◽  
Serine Threonine Kinase ◽  
Lateral Plate ◽  
Mitogen Activated Protein Kinases ◽  
Cellular Processes ◽  
Mitogen Activated Protein ◽  
Integral Role ◽  
Dual Specific Phosphatase

Abstract Mitogen-activated protein kinases play an integral role in several cellular processes. To regulate mitogen-activated protein kinases, cells express members of a counteracting group of proteins called phosphatases. In this study, we have identified a specific role that one member of this family of phosphatases, dual-specific phosphatase-5 (Dusp-5) plays in vascular development in vivo. We have determined that dusp-5 is expressed in angioblasts and in established vasculature and that it counteracts the function of a serine threonine kinase, Snrk-1, which also plays a functional role in angioblast development. Together, Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1. Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1–Dusp-5 signaling pathway in human disease.

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