Star-shaped poly(ethylene oxide)‑block‑poly(caprolactone) conjugated silver nanoparticles: A colorimetric probe for cephalexin in environmental, biological and pharmaceutical samples

2019 ◽  
Vol 149 ◽  
pp. 104048 ◽  
Author(s):  
Sana Rahim ◽  
Adnan Murad Bhayo ◽  
Muhammad Raza Shah ◽  
Muhammad Imran Malik
Soft Matter ◽  
2009 ◽  
Vol 5 (16) ◽  
pp. 3086 ◽  
Author(s):  
Dave J. Adams ◽  
Craig Kitchen ◽  
Sarah Adams ◽  
Steve Furzeland ◽  
Derek Atkins ◽  
...  

2016 ◽  
Vol 4 (4) ◽  
pp. 726-742 ◽  
Author(s):  
Poornima Dubey ◽  
P. Gopinath

An intrinsic property of many anticancer drugs including niclosamide is poor water solubility, which hindered their translation from laboratory to clinics.


2012 ◽  
Vol 134 (2-3) ◽  
pp. 557-561 ◽  
Author(s):  
Leonard D. Tijing ◽  
Michael Tom G. Ruelo ◽  
Altangerel Amarjargal ◽  
Hem Raj Pant ◽  
Chan-Hee Park ◽  
...  

2020 ◽  
Vol 7 (10) ◽  
pp. 201097
Author(s):  
Sana Rahim ◽  
Samina Perveen ◽  
Shakil Ahmed ◽  
Muhammad Raza Shah ◽  
Muhammad Imran Malik

The antibacterial activity of silver nanoparticles (AgNPs) stabilized with a four-armed star-shaped poly(ε-caprolactone)-block-poly(ethylene oxide) copolymer [St-P(CL-b-EO)] and its application as a drug delivery vehicle for cephalexin (Cp) was evaluated against pathogenic Staphylococcus aureus . The prepared AgNPs were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, zeta sizer and atomic force microscopy (AFM). The antibacterial efficiency of Cp is enhanced several-fold by its delivery through complexation with St-P(CL-b-EO)-AgNPs, monitored by microplate assay and biofilm destruction studies. Finally, the visual destruction of bacterial cells and its biofilms by employing Cp and its conjugates at their minimum inhibitory concentration (MIC 50 ) and minimum biofilm inhibitory concentration (MBIC 50 ), respectively, is observed by topographic imaging by AFM. Enhanced antibacterial activity of St-P(CL-b-EO)-AgNPs loaded Cp is attributed to penetrative nature of the drug cargo St-P(CL-b-EO)-AgNPs towards the bacterial cell wall.


2008 ◽  
Vol 362 (1-2) ◽  
pp. 153-162 ◽  
Author(s):  
Mickael Chausson ◽  
Ann-Sophie Fluchère ◽  
Emmanuel Landreau ◽  
Youssef Aguni ◽  
Yves Chevalier ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document