Experimental and simulation studies on the role of fluid velocity during particle separation in a liquid–solid fluidized bed

2007 ◽  
Vol 82 (4) ◽  
pp. 211-221 ◽  
Author(s):  
A.K. Mukherjee ◽  
B.K. Mishra
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sensen Zhang ◽  
Baolei Yuan ◽  
Jordy Homing Lam ◽  
Jun Zhou ◽  
Xuan Zhou ◽  
...  

AbstractPannexin1 (PANX1) is a large-pore ATP efflux channel with a broad distribution, which allows the exchange of molecules and ions smaller than 1 kDa between the cytoplasm and extracellular space. In this study, we show that in human macrophages PANX1 expression is upregulated by diverse stimuli that promote pyroptosis, which is reminiscent of the previously reported lipopolysaccharide-induced upregulation of PANX1 during inflammasome activation. To further elucidate the function of PANX1, we propose the full-length human Pannexin1 (hPANX1) model through cryo-electron microscopy (cryo-EM) and molecular dynamics (MD) simulation studies, establishing hPANX1 as a homo-heptamer and revealing that both the N-termini and C-termini protrude deeply into the channel pore funnel. MD simulations also elucidate key energetic features governing the channel that lay a foundation to understand the channel gating mechanism. Structural analyses, functional characterizations, and computational studies support the current hPANX1-MD model, suggesting the potential role of hPANX1 in pyroptosis during immune responses.


2021 ◽  
Vol 1034 (1) ◽  
pp. 012172
Author(s):  
Wayan Sujana ◽  
Komang Astana Widi ◽  
Gerald A. Pohan ◽  
Tutut Nani Prihatmi ◽  
Luh Dina Ekasari

2009 ◽  
Vol 289-292 ◽  
pp. 293-300
Author(s):  
L. Sánchez ◽  
F.J. Bolívar ◽  
M.P. Hierro ◽  
F.J. Pérez

In this work, iron aluminide coatings were developed by Chemical Vapor Deposition in Fluidized Bed Reactor (CVD-FBR) on ferritic-martensitic steels. Small additions of zirconium powder were introduced in the fluidized bed; as a consequence, the obtained coatings are thicker than that without zirconium additions. When Zr powders are added in the fluidized bed, the deposition atmosphere drastically changes, leading to increase the deposition rate. Thermodynamic calculations were carried out to simulate the modifications in the CVD atmosphere in the Al/Zr deposition system in comparison to the single aluminization. In order to optimize the conditions of the deposition, parameters such as temperature and concentration of zirconium introduced into the bed were evaluated and compared with the results obtained for the single aluminum deposition.


2020 ◽  
Vol 7 (1) ◽  
pp. 52-64
Author(s):  
Shailesh Narayanrao Khekale ◽  
Ramesh D. Askhedkar ◽  
Rajesh H. Parikh

The emergency department (ED) plays crucial role in providing 24-hour healthcare services to the ill with speed, accuracy, and sympathy. ED faces the problem of patient waiting time, which leads to patient dissatisfaction and patient crowding. This paper presents a systematic literature review of simulation of ED in healthcare systems from 1970 to 2013. The objectives of this review are to highlight the importance and role of simulation studies to solve the problem of patient waiting time faced by the ED. It also discusses how simulation can be better applied as a tool to solve these problems. The authors found that these simulation studies focus important insights into ED problems, but they also had some limitations that should be addressed.


1991 ◽  
Vol 64 (1-2) ◽  
pp. 159-164 ◽  
Author(s):  
O. Harel ◽  
Y. Zimmels ◽  
W. Resnick

Sign in / Sign up

Export Citation Format

Share Document