Near-infrared laser photothermal therapy of cancer by using gold nanoparticles: Computer simulations and experiment

2007 ◽  
Vol 22 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Irina L. Maksimova ◽  
Garif G. Akchurin ◽  
Boris N. Khlebtsov ◽  
Georgy S. Terentyuk ◽  
Georgy G. Akchurin ◽  
...  
2007 ◽  
Author(s):  
George G. Akchurin ◽  
Garif G. Akchurin ◽  
Vladimir A. Bogatyrev ◽  
Irina L. Maksimova ◽  
George A. Seliverstov ◽  
...  

2010 ◽  
Author(s):  
Georgy G. Akchurin ◽  
Akchurin G. Garif ◽  
Irina L. Maksimova ◽  
Alexander A. Skaptsov ◽  
Georgy S. Terentyuk ◽  
...  

Langmuir ◽  
2020 ◽  
Vol 36 (15) ◽  
pp. 4033-4043
Author(s):  
Xue Jiang ◽  
Yanxing Wang ◽  
Danyang Xu ◽  
Bi Lin ◽  
Fan Yang ◽  
...  

2019 ◽  
Vol 7 (24) ◽  
pp. 3811-3825 ◽  
Author(s):  
Panchanathan Manivasagan ◽  
Seung Won Jun ◽  
Van Tu Nguyen ◽  
Nguyen Thanh Phong Truong ◽  
Giang Hoang ◽  
...  

FA–COS–TGA–GNRs–DOX have been successfully designed as a drug delivery system for chemo-photothermal combination therapy.


2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hadiyah N. Green ◽  
Dmitry V. Martyshkin ◽  
Cynthia M. Rodenburg ◽  
Eben L. Rosenthal ◽  
Sergey B. Mirov

The mastery of active tumor targeting is a great challenge in near infrared photothermal therapy (NIRPTT). To improve efficiency for targeted treatment of malignant tumors, we modify the technique of conjugating gold nanoparticles to tumor-specific antibodies. Polyethylene glycol-coated (PEGylated) gold nanorods (GNRs) were fabricated and conjugated to an anti-EGFR antibody. We characterized the conjugation efficiency of the GNRs by comparing the efficiency of antibody binding and the photothermal effect of the GNRs before and after conjugation. We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.


Nanoscale ◽  
2014 ◽  
Vol 6 (21) ◽  
pp. 12591-12600 ◽  
Author(s):  
Zhiguo Zhou ◽  
Jun Wang ◽  
Wei Liu ◽  
Chao Yu ◽  
Bin Kong ◽  
...  

2018 ◽  
Vol 24 (23) ◽  
pp. 2719-2728 ◽  
Author(s):  
Yi Liu ◽  
Wenhui Ma ◽  
Jing Wang

Gold nanoparticles (AuNPs) are promising biomedical agents in terms of both imaging and therapy, exhibiting excellent physical and chemical characteristics. The actions of AuNPs can be remotely controlled using strong near-infrared (NIR) light, associated with minimal lateral invasion. Employing the photoacoustic (PA) principle, AuNPs integrate imaging and temperature control, affording both diagnosis and treatment mediated by NIR light. We here review recent progress in the theranostic field employing AuNPs to both PA and photothermal ends.


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