Three-dimensional dynamics of temperature fields in phantoms and biotissue under IR laser photothermal therapy using gold nanoparticles and ICG dye

2010 ◽  
Author(s):  
Georgy G. Akchurin ◽  
Akchurin G. Garif ◽  
Irina L. Maksimova ◽  
Alexander A. Skaptsov ◽  
Georgy S. Terentyuk ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Three Dimensional ◽  
Temperature Fields ◽  
Ir Laser ◽  
Laser Photothermal Therapy

Visualization and Quantification of Gold Nanorods Distribution in Prostatic Tumors Using MicroCT Imaging

2012 ◽  
Author(s):  
N. Manuchehrabadi ◽  
A. Attaluri ◽  
H. Cai ◽  
R. Edziah ◽  
E. Lalanne ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Cell Damage ◽  
Critical Mass ◽  
Three Dimensional ◽  
Transport Processes ◽  
Temperature Fields ◽  
Systemic Delivery ◽  
High Concentration ◽  
Laser Photothermal Therapy

One uncertainty in use of gold nanorods for laser photothermal therapy is the non-uniform spreading of gold nanorods in tissue after either systemic delivery or intratumoral injections. High concentration of gold nanorods in certain areas influences the resulted optical absorption of the laser and thermal damage to tumors. This also provides challenges in designing optimal heating protocols via modeling thermal transport in laser photothermal therapy. For successful cancer treatment, the tissue should be heated with minimum thermal dosage to induce tumor cell damage, while minimizing overheating in the surrounding healthy tissues. Thus, one of the main challenges for reliable cancer therapy is to precisely control loading and distribution of gold nanorods in the tumour tissue. The critical mass transport processes are the distribution of gold nanorods after injection to the tumor and the redistribution of gold nanorods during laser treatment. Since tumors are opaque, nanostructure distribution in tissue is often studied either by theoretical modeling approaches1, or via dye enhanced imaging on superficial layers of tumors.2 It is important to find a technique which can directly visualize and analyze three-dimensional nanostructure distribution of tumors. Three-dimensional reconstructions of tumors with the ability to trace gold nanorod spreading have the potential for precise theoretical simulation of temperature fields. Previous studies showed that computer tomography (CT) scan is a promising technique to be utilized to characterize the distribution of intratumorally injected magnetic nanoparticles in tumors 3.

Near-infrared laser photothermal therapy of cancer by using gold nanoparticles: Computer simulations and experiment

2007 ◽  
Vol 22 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Irina L. Maksimova ◽  
Garif G. Akchurin ◽  
Boris N. Khlebtsov ◽  
Georgy S. Terentyuk ◽  
Georgy G. Akchurin ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Computer Simulations ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Laser Photothermal Therapy

Near-infrared laser photothermal therapy and photodynamic inactivation of cells by using gold nanoparticles and dyes

2007 ◽  
Author(s):  
George G. Akchurin ◽  
Garif G. Akchurin ◽  
Vladimir A. Bogatyrev ◽  
Irina L. Maksimova ◽  
George A. Seliverstov ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Photodynamic Inactivation ◽  
Laser Photothermal Therapy

Gold Nanoparticle-Enhanced Laser-Induced Breakdown Spectroscopy and Three-Dimensional Contour Imaging of an Aluminum Alloy

2020 ◽  
pp. 000370282097304
Author(s):  
Amal A. Khedr ◽  
Mahmoud A. Sliem ◽  
Mohamed Abdel-Harith
Keyword(s):  
Gold Nanoparticles ◽  
Aluminum Alloy ◽  
Three Dimensional ◽  
Plasma Temperature ◽  
Spectral Lines ◽  
Laser Induced Breakdown Spectroscopy ◽  
Al Alloy ◽  
Boltzmann Plot ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

In the present work, nanoparticle-enhanced laser-induced breakdown spectroscopy was used to analyze an aluminum alloy. Although LIBS has numerous advantages, it suffers from low sensitivity and low detection limits compared to other spectrochemical analytical methods. However, using gold nanoparticles helps to overcome such drawbacks and enhances the LIBS sensitivity in analyzing aluminum alloy in the current work. Aluminum was the major element in the analyzed samples (99.9%), while magnesium (Mg) was the minor element (0.1%). The spread of gold nanoparticles onto the Al alloy and using a laser with different pulse energies were exploited to enhance the Al alloy spectral lines. The results showed that Au NPs successfully improved the alloy spectral lines intensity by eight times, which could be useful for detecting many trace elements in higher matrix alloys. Under the assumption of local thermodynamic equilibrium, the Boltzmann plot was used to calculate the plasma temperature. Besides, the electron density was calculated using Mg and H lines at Mg(I) at 285.2 nm and Hα(I) at 656.2 nm, respectively. Three-dimensional contour mapping and color fill images contributed to understanding the behavior of the involved effects.

Evaluation of photodynamic therapy efficiency using an in vitro three-dimensional microfluidic breast cancer tissue model

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 735-744 ◽  
Author(s):  
Yamin Yang ◽  
Xiaochuan Yang ◽  
Jin Zou ◽  
Chao Jia ◽  
Yue Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Three Dimensional ◽  
Therapeutic Agents ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Tissue Model

A microfluidic-based in vitro three-dimensional (3D) breast cancer tissue model was established for determining the efficiency of photodynamic therapy (PDT) with therapeutic agents (photosensitizer and gold nanoparticles) under various irradiation conditions.

Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy

2019 ◽  
Vol 554 ◽  
pp. 256-263 ◽  
Author(s):  
Nihal S. Elbialy ◽  
Mohamed M. Fathy ◽  
Reem AL-Wafi ◽  
Reem Darwesh ◽  
Umama A. Abdel-dayem ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Targeted Drug
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