tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes

2022 ◽  
Author(s):  
Wen Zhang ◽  
Marcus Foo ◽  
A. Murat Eren ◽  
Tao Pan
Keyword(s):  
Trna Modification

scholarly journals Correction to article ‘Iron–sulfur biology invades tRNA modification: the case of U34 sulfuration’

2021 ◽  
Author(s):  
Jingjing Zhou ◽  
Marine Lénon ◽  
Jean-Luc Ravanat ◽  
Nadia Touati ◽  
Christophe Velours ◽  
...  
Keyword(s):  
Trna Modification ◽  
Iron Sulfur

scholarly journals Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability

2021 ◽  
Vol 7 (13) ◽  
pp. eabf3072
Author(s):  
Y. Nagayoshi ◽  
T. Chujo ◽  
S. Hirata ◽  
H. Nakatsuka ◽  
C.-W. Chen ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
State Level ◽  
Memory Deficits ◽  
Ribosome Profiling ◽  
Translation Efficiency ◽  
Trna Modification ◽  
Synaptic Organization ◽  
Transfer Rnas ◽  
The Brain

FtsJ RNA 2′-O-methyltransferase 1 (FTSJ1) gene has been implicated in X-linked intellectual disability (XLID), but the molecular pathogenesis is unknown. We show that Ftsj1 is responsible for 2′-O-methylation of 11 species of cytosolic transfer RNAs (tRNAs) at the anticodon region, and these modifications are abolished in Ftsj1 knockout (KO) mice and XLID patient–derived cells. Loss of 2′-O-methylation in Ftsj1 KO mouse selectively reduced the steady-state level of tRNAPhe in the brain, resulting in a slow decoding at Phe codons. Ribosome profiling showed that translation efficiency is significantly reduced in a subset of genes that need to be efficiently translated to support synaptic organization and functions. Ftsj1 KO mice display immature synaptic morphology and aberrant synaptic plasticity, which are associated with anxiety-like and memory deficits. The data illuminate a fundamental role of tRNA modification in the brain through regulation of translation efficiency and provide mechanistic insights into FTSJ1-related XLID.

scholarly journals A Novel Gene Involved in the Survival of Streptococcus mutans under Stress Conditions

2013 ◽  
Vol 80 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Dan Li ◽  
Yukie Shibata ◽  
Toru Takeshita ◽  
Yoshihisa Yamashita
Keyword(s):  
Streptococcus Mutans ◽  
Streptococcus Pyogenes ◽  
Biofilm Formation ◽  
Acid Tolerance ◽  
Stress Conditions ◽  
Insertion Mutagenesis ◽  
Trna Modification ◽  
Content Type ◽  
Virulence Proteins ◽  
Random Insertion

ABSTRACTAStreptococcus mutansmutant defective in aciduricity was constructed by random-insertion mutagenesis. Sequence analysis of the mutant revealed a mutation ingidA, which is known to be involved in tRNA modification inStreptococcus pyogenes. Complementation ofgidAbyS. pyogenesgidArecovered the acid tolerance ofS. mutans. Although thegidA-inactivatedS. pyogenesmutant exhibited significantly reduced expression of multiple extracellular virulence proteins, theS. mutansmutant did not. On the other hand, thegidAmutant ofS. mutansshowed reduced ability to withstand exposure to other stress conditions (high osmotic pressure, high temperature, and bacitracin stress) besides an acidic environment. In addition, loss of GidA decreased the capacity for glucose-dependent biofilm formation by over 50%. This study revealed thatgidAplays critical roles in the survival ofS. mutansunder stress conditions, including lower pH.

Abstract 2370: Tumor suppression potential of tRNA modification enzyme TruBs via let-7

2021 ◽  
Author(s):  
Ryota Kurimoto ◽  
Hiroki Tsutsumi ◽  
Saki Ikeuchi ◽  
Hiroshi Asahara
Keyword(s):  
Tumor Suppression ◽  
Trna Modification ◽  
Modification Enzyme

scholarly journals Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein

2017 ◽  
Vol 1863 (12) ◽  
pp. 3294-3302 ◽  
Author(s):  
Stephanie Oerum ◽  
Martine Roovers ◽  
Michael Leichsenring ◽  
Cécile Acquaviva-Bourdain ◽  
Frauke Beermann ◽  
...  
Keyword(s):  
Trna Modification ◽  
Missense Mutations ◽  
Mitochondrial Trna
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