Copper, nickel and zinc complexes of a new water-soluble thiosemicarbazone ligand: Synthesis, characterization, stability and biological evaluation

2017 ◽  
Vol 248 ◽  
pp. 658-667 ◽  
Author(s):  
Seyed Abolfazl Hosseini-Yazdi ◽  
Azadeh Mirzaahmadi ◽  
Ali Akbar Khandar ◽  
Majid Mahdavi ◽  
Arezoo Rahimian ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Zinc Complexes ◽  
Water Soluble ◽  
Copper Nickel ◽  
Thiosemicarbazone Ligand ◽  
Ligand Synthesis

Synthesis, crystal structures and biological evaluation of water-soluble zinc complexes of zwitterionic carboxylates

2011 ◽  
Vol 376 (1) ◽  
pp. 389-395 ◽  
Author(s):  
Jin-Xiang Chen ◽  
Wei-Er Lin ◽  
Chun-Qiong Zhou ◽  
Lee Fong Yau ◽  
Jing-Rong Wang ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Biological Evaluation ◽  
Zinc Complexes ◽  
Water Soluble ◽  
Soluble Zinc

Synthesis and Biological Evaluation of Water-Soluble 2-Boronoethylthio Compounds

1964 ◽  
Vol 7 (5) ◽  
pp. 640-643 ◽  
Author(s):  
D. S. Matteson ◽  
A. H. Soloway ◽  
D. W. Tomlinson ◽  
J. D. Campbell ◽  
G. A. Nixon
Keyword(s):  
Biological Evaluation ◽  
Water Soluble ◽  
Synthesis And Biological Evaluation

Cytotoxic and antitumoral activity of N-(9H-purin-6-yl) benzamide derivatives and related water-soluble prodrugs

2021 ◽  
Vol 14 ◽  
Author(s):  
Emeline Cros-Perrial ◽  
Steve Saulnier ◽  
Muhammad Zawwad Raza ◽  
Rémi Charmelot ◽  
David Egron ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Molecular Mechanisms ◽  
Biological Evaluation ◽  
Water Soluble ◽  
Antitumoral Activity ◽  
Cell Cycle Distribution ◽  
Synergistic Activity ◽  
Benzamide Derivatives

Background: The development of small molecules as cancer treatments is still of both interest and importance. Objective: Having synthesized and identified the initial cytotoxic activity of a series of chemically related N-(9H-purin-6-yl) benzamide derivatives, we continued their evaluation on cancer cell models. We also synthesized water-soluble prodrugs of the main compound and performed in vivo experiments. Method: We used organic chemistry to obtain compounds of interest and prodrugs. The biological evaluation included MTT assays, synergy experiments, proliferation assays by CFSE, cell cycle distribution and in vivo antitumoral activity. Results: Our results show activities on cancer cell lines ranging from 3-39 µM for the best compounds, with both induction of apoptosis and decrease in cell proliferation. Two compounds evaluated in vivo showed weak antitumoral activity. In addition, the lead compound and its prodrug had a synergistic activity with the nucleoside analogue fludarabine in vitro and in vivo. Conclusion: Our work allowed us to gain better knowledge on the activity of N-(9H-purin-6-yl) benzamide derivatives and showed new examples of water-soluble prodrugs. More research is warranted to decipher the molecular mechanisms of the molecules.

Ni(II) complex containing a thiosemicarbazone ligand: Synthesis, spectroscopy, single-crystal X-ray crystallographic and conductivity studies

2021 ◽  
Vol 1223 ◽  
pp. 128994
Author(s):  
Uwaisulqarni M. Osman ◽  
Sharmili Silvarajoo ◽  
Khadijah H. Kamarudin ◽  
Mohamed Ibrahim Mohamed Tahir ◽  
Huey Chong Kwong
Keyword(s):  
Single Crystal ◽  
X Ray ◽  
Thiosemicarbazone Ligand ◽  
Ligand Synthesis

Water Soluble Coumarin Quaternary Ammonium Chlorides: Synthesis and Biological Evaluation

2020 ◽  
Author(s):  
Mert O. Karataş ◽  
Samir A. A. Noma ◽  
Canbolat Gürses ◽  
Sevgi Balcıoğlu ◽  
Burhan Ateş ◽  
...  
Keyword(s):  
Quaternary Ammonium ◽  
Biological Evaluation ◽  
Water Soluble ◽  
Synthesis And Biological Evaluation
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