Tooth Repair and Regeneration: Potential of Dental Stem Cells

2021 ◽  
Author(s):  
Weibo Zhang ◽  
Pamela C. Yelick
Keyword(s):  
Stem Cells ◽  
Dental Stem Cells ◽  
Regeneration Potential ◽  
Tooth Repair

scholarly journals Dental stem cells in tooth repair: A systematic review

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1955
Author(s):  
Mary Sabry Tawfik Tadros ◽  
Maha Abd-El Salam El-Baz ◽  
Mohamed Adel Ezzat Khairy Khairy
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Dental Pulp ◽  
Case Reports ◽  
Deciduous Teeth ◽  
Current Evidence ◽  
Cochrane Library ◽  
Dental Stem Cells ◽  
Pulp Regeneration ◽  
Tooth Repair

Background: Dental stem cells (DSCs) are self-renewable teeth cells, which help maintain or develop oral tissues. These cells can differentiate into odontoblasts, adipocytes, cementoblast-like cells, osteoblasts, or chondroblasts and form dentin/pulp. This systematic review aimed to summarize the current evidence regarding the role of these cells in dental pulp regeneration. Methods: We searched the following databases: PubMed, Cochrane Library, MEDLINE, SCOPUS, ScienceDirect, and Web of Science using relevant keywords. Case reports and non-English studies were excluded. We included all studies using dental stem cells in tooth repair whether in vivo or in vitro studies. Results: Dental pulp stem cell (DPSCs) is the most common type of cell. Most stem cells are incorporated and implanted into the root canals in different scaffold forms. Some experiments combine growth factors such as TDM, BMP, and G-CSF with stem cells to improve the results. The transplant of DPSCs and stem cells from apical papilla (SCAPs) was found to be associated with pulp-like recovery, efficient revascularization, enhanced chondrogenesis, and direct vascular supply of regenerated tissue. Conclusion: The current evidence suggests that DPSCs, stem cells from human exfoliated deciduous teeth, and SCAPs are capable of providing sufficient pulp regeneration and vascularization. For the development of the dental repair field, it is important to screen for more effective stem cells, dentine releasing therapies, good biomimicry scaffolds, and good histological markers.

scholarly journals Human Amniotic Membrane as a Matrix for Endothelial Differentiation of VEGF-Treated Dental Stem Cells

2019 ◽  
Vol 12 (6) ◽  
pp. 599-613 ◽  
Author(s):  
Siti Nurnasihah Md Hashim ◽  
Muhammad Fuad Hilmi Yusof ◽  
Wafa’ Zahari ◽  
Hamshawagini Chandra ◽  
Khairul Bariah Ahmad Amin Noordin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amniotic Membrane ◽  
Endothelial Differentiation ◽  
Human Amniotic Membrane ◽  
Dental Stem Cells

Immunomodulatory properties and in vivo osteogenesis of human dental stem cells from fresh and cryopreserved dental follicles

2015 ◽  
Vol 90 (1-3) ◽  
pp. 48-58 ◽  
Author(s):  
Young-Hoon Kang ◽  
Hye-Jin Lee ◽  
Si-Jung Jang ◽  
June-Ho Byun ◽  
Jong-Sil Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Stem Cells ◽  
Immunomodulatory Properties

scholarly journals Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Maurizio Bossù ◽  
Andrea Pacifici ◽  
Daniele Carbone ◽  
Gianluca Tenore ◽  
Gaetano Ierardo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Current Knowledge ◽  
Dental Stem Cells ◽  
Therapeutic Tool ◽  
Exponential Increase ◽  
Major Interest ◽  
Adult Mesenchymal Stem Cells ◽  
Therapeutic Protocols ◽  
Near Future

In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting the current knowledge for each class of dental stem cells and to identify their potential clinical applications as therapeutic tool in various branches of dentistry.

scholarly journals Tumorigenicity analysis of heterogeneous dental stem cells and its self-modification for chromosome instability

Cell Cycle ◽  
2015 ◽  
Vol 14 (21) ◽  
pp. 3396-3407 ◽  
Author(s):  
Zhaosong Meng ◽  
Guoqing Chen ◽  
Jinlong Chen ◽  
Bo Yang ◽  
Mei Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Chromosome Instability ◽  
Dental Stem Cells

Musculo-skeletal and dental stem cells in mammals

Stem Cells ◽  
2020 ◽  
pp. 193-216
Author(s):  
Mary L. Clarke ◽  
Jonathan Frampton
Keyword(s):  
Stem Cells ◽  
Dental Stem Cells

scholarly journals Secretome proteins regulate comparative osteogenic and adipogenic potential in bone marrow and dental stem cells

Biochimie ◽  
2018 ◽  
Vol 155 ◽  
pp. 129-139 ◽  
Author(s):  
Ajay Kumar ◽  
Vinod Kumar ◽  
Vidya Rattan ◽  
Vivekananda Jha ◽  
Shalmoli Bhattacharyya
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Dental Stem Cells

scholarly journals Dental pulp stem cells: Potential significance in regenerative medicine

2008 ◽  
Vol 55 (3) ◽  
pp. 170-179 ◽  
Author(s):  
Vera Todorovic ◽  
Dejan Markovic ◽  
Nadezda Milosevic-Jovcic ◽  
Marijana Petakov ◽  
Bela Balint ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Matrix Protein ◽  
Dental Pulp Stem Cells ◽  
Deciduous Teeth ◽  
High Plasticity ◽  
Dental Stem Cells ◽  
Periodontal Tissues ◽  
Extracellular Matrix Components

To date, three types of dental stem cells have been isolated: Dental Pulp Stem Cells (DPSC), Stem Cells From Human Exfoliated Deciduous Teeth (SHED) and Immature Dental Pulp Stem Cells (IDPC). These dental stem cells are considered as mesenchymal stem cells. They reside within the perivascular niche of dental pulp. They are highly proliferative, clonogenic, multipotent and are similar to mesenchymal Bone Marrow Stem Cells (BMSC). Also, they have high plasticity and can be easy isolated. The expressions of the alkaline phosphatase gene, dentin matrix protein 1 and dentinsialophosphoprotein are verified in these cells. Analyses of gene expression patterns indicated several genes which encode extracellular matrix components, cell adhesion molecules, growth factors and transcription regulators, cell signaling, cell communication or cell metabolism. In both conditions, in vivo and in vitro, these cells have the ability to differentiate into odontoblasts, chondrocytes, osteoblasts, adipocytes, neurons, melanocytes, smooth and skeletal muscles and endothelial cells. In vivo, after implantation, they have shown potential to differentiate into dentin but also into tissues like bone, adipose or neural tissue. In general, DPSCs are considered to have antiinflammatory and immunomodulatory abilities. After being grafted into allogenic tissues these cells are ableto induce immunological tolerance. Immunosuppressive effect is shown through the ability to inhibit proliferation of T lymphocytes. Dental pulp stem cells open new perspectives in therapeutic use not only in dentin regeneration, periodontal tissues and skeletoarticular, tissues of craniofacial region but also in treatment of neurotrauma, autoimmune diseases, myocardial infarction, muscular dystrophy and connective tissue damages.

scholarly journals Erratum: Number of Dental Stem Cells on Root Canal Dentin after Application of Triple Antibiotic Paste or Calcium Hydroxide: An In Vitro Study

2019 ◽  
Vol 13 (02) ◽  
pp. e1-e1
Author(s):  
Konstantinos Gougousis ◽  
Dimitrios G. Giannakoulas ◽  
Vasiliki Taraslia ◽  
Anastasia Agrafioti ◽  
Ema Anastasiadou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Calcium Hydroxide ◽  
Root Canal ◽  
In Vitro Study ◽  
Vitro Study ◽  
Dental Stem Cells ◽  
Triple Antibiotic Paste ◽  
Root Canal Dentin
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