scholarly journals Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Maurizio Bossù ◽  
Andrea Pacifici ◽  
Daniele Carbone ◽  
Gianluca Tenore ◽  
Gaetano Ierardo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Current Knowledge ◽  
Dental Stem Cells ◽  
Therapeutic Tool ◽  
Exponential Increase ◽  
Major Interest ◽  
Adult Mesenchymal Stem Cells ◽  
Therapeutic Protocols ◽  
Near Future

In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting the current knowledge for each class of dental stem cells and to identify their potential clinical applications as therapeutic tool in various branches of dentistry.

scholarly journals Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review

2018 ◽  
Vol 18 (3) ◽  
pp. 264 ◽  
Author(s):  
Roberto Berebichez-Fridman ◽  
Pablo R. Montero-Olvera
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Adult Stem Cells ◽  
Current Knowledge ◽  
Clinical Applications ◽  
The Body ◽  
Differentiation Potential ◽  
Advantages And Disadvantages

First discovered by Friedenstein in 1976, mesenchymal stem cells (MSCs) are adult stem cells found throughout the body that share a fixed set of characteristics. Discovered initially in the bone marrow, this cell source is considered the gold standard for clinical research, although various other sources—including adipose tissue, dental pulp, mobilised peripheral blood and birth-derived tissues—have since been identified. Although similar, MSCs derived from different sources possess distinct characteristics, advantages and disadvantages, including their differentiation potential and proliferation capacity, which influence their applicability. Hence, they may be used for specific clinical applications in the fields of regenerative medicine and tissue engineering. This review article summarises current knowledge regarding the various sources, characteristics and therapeutic applications of MSCs.Keywords: Mesenchymal Stem Cells; Adult Stem Cells; Regenerative Medicine; Cell Differentiation; Tissue Engineering.

Dental stem cells: recent progresses in tissue engineering and regenerative medicine

2017 ◽  
Vol 49 (8) ◽  
pp. 644-651 ◽  
Author(s):  
João Botelho ◽  
Maria Alzira Cavacas ◽  
Vanessa Machado ◽  
José João Mendes
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Regenerative Medicine ◽  
Dental Stem Cells

scholarly journals The Neurovascular Properties of Dental Stem Cells and Their Importance in Dental Tissue Engineering

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Jessica Ratajczak ◽  
Annelies Bronckaers ◽  
Yörg Dillen ◽  
Pascal Gervois ◽  
Tim Vangansewinkel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Tissue Growth ◽  
Deciduous Teeth ◽  
Human Tooth ◽  
Dental Stem Cells ◽  
Dental Tissue ◽  
Periodontal Ligament Stem Cells ◽  
Essential Components ◽  
Dental Tissue Engineering

Within the field of tissue engineering, natural tissues are reconstructed by combining growth factors, stem cells, and different biomaterials to serve as a scaffold for novel tissue growth. As adequate vascularization and innervation are essential components for the viability of regenerated tissues, there is a high need for easily accessible stem cells that are capable of supporting these functions. Within the human tooth and its surrounding tissues, different stem cell populations can be distinguished, such as dental pulp stem cells, stem cells from human deciduous teeth, stem cells from the apical papilla, dental follicle stem cells, and periodontal ligament stem cells. Given their straightforward and relatively easy isolation from extracted third molars, dental stem cells (DSCs) have become an attractive source of mesenchymal-like stem cells. Over the past decade, there have been numerous studies supporting the angiogenic, neuroprotective, and neurotrophic effects of the DSC secretome. Together with their ability to differentiate into endothelial cells and neural cell types, this makes DSCs suitable candidates for dental tissue engineering and nerve injury repair.

scholarly journals Dental stem cells and their application in dentistry.

2020 ◽  
Vol 9 (3) ◽  
pp. 220-233
Author(s):  
Heber Arbildo-Vega ◽  
◽  
Fredy Cruzado-Oliva ◽  
Edward Infantes-Ruiz ◽  
◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Dental Stem Cells ◽  
Periodontal Ligament Stem Cells ◽  
Dental Tissues ◽  
Proliferation Capacity ◽  
Apical Papilla ◽  
Many Sources ◽  
Follicle Stem Cells

Recent advances in tissue engineering and regenerative medicine offer a long-term solution through biological repair, replacement of damaged teeth or maintenance and improvement of tissue and organ function through the use of stem cells. Stem cells or also called universal cells, progenitor cells or precursor cells; they are primitive, undifferentiated, clonogenic cells that are characterized by their self-renewal capabilities and that can be differentiated into more specialized cells with specific functions. Currently many sources are known from where you can obtain stem cells, one of which are those obtained from oral or dental tissues, called dental stem cells (DSC), from where it has been possible to identify, isolate and characterize around 8 unique populations: dental pulp stem cells (DPSC), human exfoliated deciduous tooth stem cells (SHED), periodontal ligament stem cells (PLDSC), dental follicle stem cells (DFSC), stem cells derived from bone alveolar (CMHA), the stem cells of the apical papilla (SCAP), the stem cells of the dental germ (DGSC) and the gingival stem cells (GSC). These DSC have attracted attention in recent years due to their accessibility, plasticity and high proliferation capacity. Currently, DSC have shown that they can be used in endodontic and periodontal regenerative therapy, in the regeneration of dentin and bone and in dental bioengineering. Tissue engineering methodologies combined with a greater understanding of the biology of DSCs will provide powerful tools for a broader spectrum of their application in various future therapeutic strategies.

scholarly journals A REVIEW ON DENTAL STEM CELLS AND TISSUE ENGINEERING: CONNECTING THE LINK

2020 ◽  
Vol 11 (3) ◽  
pp. 98-102
Author(s):  
Abhimanyu Sharma ◽  
Minni Chadha ◽  
Priya Yadav ◽  
Prachi Garhia ◽  
Sana Chawla
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Dental Stem Cells

scholarly journals Tooth Tissue Engineering: The Importance of Blood Products as a Supplement in Tissue Culture Medium for Human Pulp Dental Stem Cells

2015 ◽  
Vol 21 (21-22) ◽  
pp. 2639-2648 ◽  
Author(s):  
Ricardo Luiz Pisciolaro ◽  
Monica Talarico Duailibi ◽  
Neil Ferreira Novo ◽  
Yara Juliano ◽  
Debora Pallos ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Tissue Culture ◽  
Culture Medium ◽  
Tissue Culture Medium ◽  
Blood Products ◽  
Dental Stem Cells ◽  
Tooth Tissue

scholarly journals Deciphering the Epigenetic Code of Stem Cells Derived From Dental Tissues

2022 ◽  
Vol 2 ◽  
Author(s):  
Ye Li ◽  
Xitong Zhao ◽  
Meng Sun ◽  
Dandan Pei ◽  
Ang Li
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Translational Medicine ◽  
Current Knowledge ◽  
Therapeutic Interventions ◽  
The Novel ◽  
Epigenetic Alterations ◽  
Dental Tissues ◽  
Epigenetic Code ◽  
Novel Therapeutic

Stem cells derived from dental tissues (DSCs) exhibit multipotent regenerative potential in pioneering tissue engineering regimens. The multipotency of DSCs is critically regulated by an intricate range of factors, of which the epigenetic influence is considered vital. To gain a better understanding of how epigenetic alterations are involved in the DSC fate determination, the present review overviews the current knowledge relating to DSC epigenetic modifications, paying special attention to the landscape of epigenetic modifying agents as well as the related signaling pathways in DSC regulation. In addition, insights into the future opportunities of epigenetic targeted therapies mediated by DSCs are discussed to hold promise for the novel therapeutic interventions in future translational medicine.

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