Synthesis and characterization, antimicrobial activity, DNA binding and DNA cleavage studies of new 5-chloro-2-[4-phenylthiazol-2-yl-iminomethyl]phenol metal complexes

2015 ◽  
Vol 1082 ◽  
pp. 62-79 ◽  
Author(s):  
Abdel-Nasser M.A. Alaghaz ◽  
Mohamed E. Zayed ◽  
Suliman A. Alharbi
Keyword(s):  
Antimicrobial Activity ◽  
Dna Binding ◽  
Metal Complexes ◽  
Dna Cleavage ◽  
Synthesis And Characterization

Half-sandwich iridiumIII complexes with pyrazole-substituted heterocyclic frameworks and their biological applications

2016 ◽  
Vol 40 (12) ◽  
pp. 9968-9980 ◽  
Author(s):  
Sanjay B. Gajera ◽  
Jugal V. Mehta ◽  
Parth Thakor ◽  
Vasudev R. Thakkar ◽  
Piyushkumar C. Chudasama ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dna Binding ◽  
Metal Complexes ◽  
Antiproliferative Activity ◽  
Dna Cleavage ◽  
Biological Function ◽  
Biological Applications ◽  
Half Sandwich

Enhancement in the biological function, i.e., DNA binding, molecular docking, antiproliferative activity and DNA cleavage, of metal complexes as compared to free ligands is observed.

scholarly journals Synthesis, Characterisation, Antimicrobial activity and DNA Cleavage of (E)-2-((Tetrazolo[1,5-A]Quinolin-4- ylmethylene)Amino)Phenol Schiff base Metal complexes

2020 ◽  
Vol 13 (2) ◽  
pp. 29-37
Author(s):  
Anilkumar Ambala ◽  
Ch. Abraham Lincoln
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Dna Cleavage ◽  
Analytical Data ◽  
Amino Phenol ◽  
Ft Ir ◽  
Uv Visible ◽  
Schiff Base Metal Complexes

A series of novel (E)-2-((Tetrazolo[1,5-a]quinolin-4-ylmethylene)amino)phenol Cu(II), Co(II), Ni(II), Zn(II) and Mn (II) metal complexes have been synthesized 1:1 metal to ligand ratio, and these complexes were characterized by using analytical data such as FT-IR, UV-visible, Mass spectroscopy, SEM, EDX, TGA and magnetic moment measurements. The ligand and all the metal complexes were tested in vitro antimicrobial activity and DNA cleavage studies.

Synthesis, characterization, antimicrobial, pesticidal and DNA cleavage activity of germanium(IV) derivatives of 3-(2-methyl-2,3-dihydro-benzthiazo-2-yl)-chromen-2-one and N′-[1-2-oxo-2H-chrome-3yl-ethylidene]-hydrazinecarbodithionic acid benzyl ester ligands

2011 ◽  
Vol 34 (5-6) ◽  
pp. 139-146 ◽  
Author(s):  
Latika Dawara ◽  
Nighat Fahmi ◽  
R.V. Singh
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Benzyl Ester ◽  
Germanium Atom ◽  
Conventional Heating ◽  
Molar Ratio ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

Abstract The new ligands 3-(2-methyl-2,3-dihydro-benzthiazo-2-yl)-chromen-2one (AcBzH) and N′-[1-2-oxo-2H-chrome-3yl-ethylidene]-hydrazinecarbodithionic acid benzyl ester (AcBDTZH) were prepared by the reaction of 3-acetyl-2H-chromen-2-one with 2-aminothiophenol and S-benzyl dithiocarbazate, respectively. The germanium(IV) complexes have been prepared by reacting Ph3GeCl and Me3GeCl in 1:1 molar ratio with these monofunctional bidentate AcBzH and AcBDTZH ligands by using microwave as well as conventional heating methods for comparison purposes. All the synthesized compounds were characterized by elemental analyses, melting point, IR, 1H-NMR 13C-NMR, mass and X-ray powder diffraction techniques. These studies showed that the ligands coordinated to the germanium atom in a monobasic bidentate manner and trigonal bipyramidal environment around the germanium atom have been established for the complexes. To evaluate the effect of metal ion upon chelation, both ligands and their complexes have been screened for their antimicrobial activity against the various pathogenic bacterial and fungal strains. The metal complexes have shown antimicrobial activity as compared to the free ligands. The pesticidal activity and DNA cleavage activity of both ligands and their metal complexes have been tested and discussed.

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