Synthesis, structural characterization and biological evaluation of novel mixed-ligand Co(II) complexes as quorum sensing inhibitory agent

2020 ◽  
Vol 1202 ◽  
pp. 127322 ◽  
Author(s):  
Cigdem Hopa ◽  
Hulya Kara ◽  
Aynur Aybey
Keyword(s):  
Quorum Sensing ◽  
Structural Characterization ◽  
Biological Evaluation ◽  
Mixed Ligand

Structural characterization and biological evaluation of antimony(III) and bismuth(III) complexes with imidazolidine-2-thione

2021 ◽  
Vol 1235 ◽  
pp. 130270
Author(s):  
Okan Ucar ◽  
Anita M. Grześkiewicz ◽  
Christina Banti ◽  
Sotiris K. Hadjikakou ◽  
Ibrahim I. Ozturk
Keyword(s):  
Structural Characterization ◽  
Biological Evaluation

scholarly journals Virtual Screening and Biological Evaluation of Anti-Biofilm Agents Targeting LuxS in the Quorum Sensing System

2021 ◽  
Vol 16 (6) ◽  
pp. 1934578X2110196
Author(s):  
Zheng Liu ◽  
Lihua Zhang ◽  
Jincai Wang ◽  
Yanping Li ◽  
Yiqun Chang ◽  
...  
Keyword(s):  
Dental Caries ◽  
Quorum Sensing ◽  
Biofilm Formation ◽  
Binding Mode ◽  
Biological Evaluation ◽  
Oral Diseases ◽  
Traditional Use ◽  
New Approach ◽  
Sensing System ◽  
Plaque Biofilm

Biofilm formation is considered as a crucial factor in various oral diseases, such as dental caries. The quorum sensing (QS) signaling system was proved to have a crucial role in the microbial dental plaque biofilm formation of Streptococcus mutans ( S. mutans). LuxS was critical to regulating the QS system and survival of the bacterium, and, therefore, compounds which target LuxS may be a potential therapy for dental caries. The binding activities of 37,170 natural compounds to LuxS were virtually screened in this study. Baicalein and paeonol were chosen for further research of the binding mode and ΔG values with LuxS. Both baicalein and paeonol inhibited the biofilm formation without influence on the growth of S. mutans. Baicalein also distinctly reduced the production of both rhamnolipids and acids. The results provide us with a new approach to combat dental caries instead of the traditional use of antibacterial chemicals.

Synthesis and structural characterization of a novel Re[P][NN][S][SO] mixed ligand rhenium(III) complex

2003 ◽  
Vol 346 ◽  
pp. 270-274 ◽  
Author(s):  
D. Papagiannopoulou ◽  
I.C. Pirmettis ◽  
M. Pelecanou ◽  
Ch. Tsoukalas ◽  
C.P. Raptopoulou ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Mixed Ligand

Synthesis, Structural Characterization and Hirshfeld Surface Analysis of Mixed Ligand Copper(II) Complex

2020 ◽  
Vol 28 ◽  
pp. 100374
Author(s):  
Nagma A. Shaikh ◽  
Santosh N. Rathod ◽  
Satish S. Bhat ◽  
Naveen S. ◽  
Sabiha Shaikh ◽  
...  
Keyword(s):  
Surface Analysis ◽  
Structural Characterization ◽  
Hirshfeld Surface ◽  
Mixed Ligand ◽  
Hirshfeld Surface Analysis

scholarly journals Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa

RSC Advances ◽  
2019 ◽  
Vol 9 (50) ◽  
pp. 29273-29292 ◽  
Author(s):  
Singireddi Srinivasarao ◽  
Adinarayana Nandikolla ◽  
Shashidhar Nizalapur ◽  
Tsz Tin Yu ◽  
Sravani Pulya ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Cell Line ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Hek 293 ◽  
Line P ◽  
Synthesis And Biological Evaluation ◽  
Hek 293 Cell Line

Out of 40 benzimdazoles, 12 exhibited potent QSI activity against P. aeruginosa6p, most active QSI is docked to LasR and is less toxic against HEK 293 cell line.

Uncommon Anionic Dioxorhenium(V) and Neutral Monooxorhenium(V) Mixed-Ligand Complexes Containing Heterofunctionalized Phosphine Ligands:  Syntheses and Structural Characterization

1996 ◽  
Vol 35 (21) ◽  
pp. 6221-6229 ◽  
Author(s):  
Cristina Bolzati ◽  
Francesco Tisato ◽  
Fiorenzo Refosco ◽  
Giuliano Bandoli ◽  
Alessandro Dolmella
Keyword(s):  
Structural Characterization ◽  
Mixed Ligand ◽  
Phosphine Ligands ◽  
Mixed Ligand Complexes
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