Synthesis of  Cyclodextrins-Metronidazole Inclusion Complexes and Incorporation of Metronidazole - 2-Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Chitosan Nanoparticles.

2021 ◽  
pp. 131298
Author(s):  
Sarra Bensouiki ◽  
Fouzia Belaib ◽  
Michèle Sindt ◽  
Sandrine Rup-Jacques ◽  
Pierre Magri ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Chitosan Nanoparticles ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

Evaluation of the phase solubility of inclusion complexes of diisopropylphenol (INN) with hydroxypropyl-β-cyclodextrin

2021 ◽  
pp. 27-32
Author(s):  
Olga Mikhailovna Balakhonova ◽  
Viktoriya Sergeevna Tyukova ◽  
Stanislav Anatolievich Kedik
Keyword(s):  
Aqueous Solution ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Tween 80 ◽  
Phase Solubility ◽  
Cyclodextrin Inclusion ◽  
Solubility Method ◽  
Cyclodextrin Inclusion Complex ◽  
The Stability ◽  
Solubility Profiles

The paper presents the results of a study of the stability of aqueous solutions of inclusion complexes of hydroxypropyl-β-cyclodextrin with diisopropylphenol in various systems by the Higuchi-Connors phase solubility method. The phase solubility profiles for each system corresponding to the AN type are determined graphically, and the stability constants of the resulting inclusion complexes are calculated. An aqueous solution containing 0.2 % Tween 80 and 0.2 % mannitol was selected as the optimal condition for obtaining the hydroxypropyl-β-cyclodextrin inclusion complex with diisopropylphenol.

New Patent on Electrospinning for Increasing Rutin Loading in Nanofibers

2020 ◽  
Vol 14 (1) ◽  
pp. 35-41
Author(s):  
Na Li ◽  
Yongfang Qian ◽  
Zhen Zhang ◽  
Ying Wang ◽  
Lihua Lve ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Electrospun Nanofibers ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Loading Amount ◽  
Functional Nanofibers ◽  
Surface Morphologies ◽  
Scanning Electron

Background: The electrospinning and the bubble electrospinning provide facile ways for the fabrication of functional nanofibers by incorporating rutin/hydroxypropyl-β-cyclodextrin inclusion complex (RT/HP-β-CD-IC) in Polyvinyl Alcohol (PVA). Few patents on incorporation of rutin and cyclodextrin in nanofibers has been reported. Objective: The study aimed at increasing the loading amount of rutin in the electrospun nanofibers to obtain ultraviolet resistant property. Methods: Rutin was encapsulated in the cavity of RT/HP-β-CD and formed an inclusion complex. Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimeter (DSC) was used to verify the formation of inclusion complexes. Results: The results showed that the inclusion between rutin and HP-β-CD had been successfully formed. The surface morphologies of nanofibrous membranes were characterized by Scanning Electron Microscope (SEM), which indicated that adding RT/HP-β-CD inclusion complexes had little influence on the morphologies and diameters of the fibers. Ultraviolet resistant results also confirmed the inclusion complex had increased the loading amount in the final nanofibrous mats, and thus had good ultraviolet resistant properties. Conclusion: The formed inclusion complexes had obviously enhanced the loading amount of rutin in electrospun PVA nanofibers, indicating that encapsulation of rutin in the cavity of HP-β-CD is a good way to increase the loading amount.

scholarly journals Comprehensive Characterisation of the Ketoprofen-β-Cyclodextrin Inclusion Complex Using X-ray Techniques and NMR Spectroscopy

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4089
Author(s):  
Katarzyna Betlejewska-Kielak ◽  
Elżbieta Bednarek ◽  
Armand Budzianowski ◽  
Katarzyna Michalska ◽  
Jan K. Maurin
Keyword(s):  
Nmr Spectroscopy ◽  
Inclusion Complex ◽  
Crystal And Molecular Structure ◽  
Binding Constants ◽  
Nmr Studies ◽  
X Ray ◽  
Cyclodextrin Inclusion ◽  
Powder Samples ◽  
Cyclodextrin Inclusion Complex ◽  
Co Precipitation

Racemic ketoprofen (KP) and β-cyclodextrin (β-CD) powder samples from co-precipitation (1), evaporation (2), and heating-under-reflux (3) were analysed using X-ray techniques and nuclear magnetic resonance (NMR) spectroscopy. On the basis of NMR studies carried out in an aqueous solution, it was found that in the samples obtained by methods 1 and 2, there were large excesses of β-CD in relation to KP, 10 and 75 times, respectively, while the sample obtained by method 3 contained equimolar amounts of β-CD and KP. NMR results indicated that KP/β-CD inclusion complexes were formed and the estimated binding constants were approximately 2400 M−1, showing that KP is quite strongly associated with β-CD. On the other hand, the X-ray single-crystal technique in the solid state revealed that the (S)-KP/β-CD inclusion complex with a stoichiometry of 2:2 was obtained as a result of heating-under-reflux, for which the crystal and molecular structure were examined. Among the methods used for the preparation of the KP/β-CD complex, only method 3 is suitable.

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