Prolongation excitation wavelength of two-photon active photosensitizer for near-infrared light-induced in vitro photodynamic therapy

2021 ◽  
pp. 132030
Author(s):  
Zhongwei Xu ◽  
Xin Lu ◽  
Yuhan Zhu ◽  
Chaoya Xiong ◽  
Bo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Excitation Wavelength ◽  
Near Infrared Light ◽  
Two Photon

scholarly journals Powering rotary molecular motors with low-intensity near-infrared light

2020 ◽  
Vol 6 (44) ◽  
pp. eabb6165
Author(s):  
Lukas Pfeifer ◽  
Nong V. Hoang ◽  
Maximilian Scherübl ◽  
Maxim S. Pshenichnikov ◽  
Ben L. Feringa
Keyword(s):  
Smart Materials ◽  
Molecular Motors ◽  
Near Infrared ◽  
In Vivo Studies ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Two Photon ◽  
Low Intensity

Light-controlled artificial molecular machines hold tremendous potential to revolutionize molecular sciences as autonomous motion allows the design of smart materials and systems whose properties can respond, adapt, and be modified on command. One long-standing challenge toward future applicability has been the need to develop methods using low-energy, low-intensity, near-infrared light to power these nanomachines. Here, we describe a rotary molecular motor sensitized by a two-photon absorber, which efficiently operates under near-infrared light at intensities and wavelengths compatible with in vivo studies. Time-resolved spectroscopy was used to gain insight into the mechanism of energy transfer to the motor following initial two-photon excitation. Our results offer prospects toward in vitro and in vivo applications of artificial molecular motors.

scholarly journals Ruthenium(ii) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

2016 ◽  
Vol 4 (7) ◽  
pp. 1337-1342 ◽  
Author(s):  
Nikola Ž. Knežević ◽  
Vanja Stojanovic ◽  
Arnaud Chaix ◽  
Elise Bouffard ◽  
Khaled El Cheikh ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Porous Silicon ◽  
Cancer Therapy ◽  
Silicon Nanoparticles ◽  
Near Infrared ◽  
Infrared Light ◽  
Porous Si ◽  
Near Infrared Light ◽  
Two Photon ◽  
Photodynamic Cancer Therapy

Multifunctionalized porous Si NPs and their application in NIR photodynamic therapy and imaging of cancer are reported.

In vitro photodynamic therapy based on magnetic-luminescent Gd2O3:Yb,Er nanoparticles with bright three-photon up-conversion fluorescence under near-infrared light

2015 ◽  
Vol 44 (36) ◽  
pp. 16081-16090 ◽  
Author(s):  
Hao Li ◽  
Shaoxin Song ◽  
Wei Wang ◽  
Kezheng Chen
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Light ◽  
Precipitation Method ◽  
Homogeneous Precipitation ◽  
Near Infrared Light ◽  
Bimodal Imaging ◽  
Homogeneous Precipitation Method

Gd2O3:Yb,Er nanoparticles that can be used as promising dual-modal samples for simultaneous magnetic/optical bimodal imaging and near-infrared laser-triggered photodynamic therapy were fabricated via a homogeneous precipitation method.

A Near-Infrared Light-Excitable Immunomodulating Nano-photosensitizer for Effective Photoimmunotherapy

2021 ◽  
Author(s):  
Yadan Zheng ◽  
Zhanzhan Zhang ◽  
Qi Liu ◽  
Ying Wang ◽  
Jialei Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Therapeutic Efficiency ◽  
Immunosuppressive Tumor Microenvironment

Photodynamic therapy has great potential for tumor ablation and the activation of antitumor immune responses. However, its overall therapeutic efficiency is often limited by the immunosuppressive tumor microenvironment. We developed...

scholarly journals Two-Photon–NIR-II Antimicrobial Graphene-Nanoagent for Ultraviolet–NIR Imaging and Photoinactivation

2021 ◽  
Author(s):  
WEN-SHUO KUO ◽  
Chia-Yuan Chang ◽  
Ping-Ching Wu ◽  
Jiu-Yao Wang
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Chemical Modification ◽  
Near Infrared ◽  
Photon Absorption ◽  
Excitation Wavelength ◽  
Strong Electron ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Abstract BackgroundNitrogen doping and amino-group functionalization, which result in strong electron donation, can be achieved through chemical modification. Large π-conjugated systems of graphene quantum dot (GQD)-based materials acting as electron donors can be chemically manipulated with low two-photon excitation energy in a short photoexcitation time for improving the charge transfer efficiency of sorted nitrogen-doped amino acid–functionalized GQDs (sorted amino-N-GQDs). ResultsIn this study, a self-developed femtosecond Ti-sapphire laser optical system (222.7 nJ pixel−1 with 100-170 scans, approximately 0.65-1.11 s of total effective exposure times; excitation wavelength: 960 nm in the near-infrared II region) was used for chemical modification. The sorted amino-N-GQDs exhibited enhanced two-photon absorption, post-two-photon excitation stability, two-photon excitation cross-section, and two-photon luminescence through the radiative pathway. The lifetime and quantum yield of the sorted amino-N-GQDs decreased and increased, respectively. Furthermore, the sorted amino-N-GQDs exhibited excitation-wavelength-independent photoluminescence in the near-infrared region and generated reactive oxygen species after two-photon excitation. An increase in the size of the sorted amino-N-GQDs boosted photochemical and electrochemical efficacy and resulted in high photoluminescence quantum yield and highly efficient two-photon photodynamic therapy. ConclusionThe sorted dots can be used in two-photon contrast probes for tracking and localizing analytes during two-photon imaging in a biological environment and for conducting two-photon photodynamic therapy for eliminating infectious microbes.

scholarly journals Indocyanine Green-lactosome and Near-infrared Light-based Intraoperative Imaging and Photodynamic Therapy for Metastatic Bone Tumors

2014 ◽  
Vol 27 (4) ◽  
pp. 449-452 ◽  
Author(s):  
Toshinori Tsukanishi ◽  
Toru Funayama ◽  
Eiichi Ozeki ◽  
Isao Hara ◽  
Tetsuya Abe ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Bone Tumors ◽  
Near Infrared ◽  
Intraoperative Imaging ◽  
Infrared Light ◽  
Near Infrared Light

scholarly journals Dynamics of Oxygen-Independent Photocleavage of Blebbistatin as a One-Photon Blue or Two-Photon Near-Infrared Light-Gated Hydroxyl Radical Photocage

2018 ◽  
Vol 140 (46) ◽  
pp. 15957-15968 ◽  
Author(s):  
Ming-De Li ◽  
Nai-Kei Wong ◽  
Jia Xiao ◽  
Ruixue Zhu ◽  
Liangliang Wu ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Two Photon
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