The effect of menarche age, parity and lactation on bone mineral density in premenopausal ambulatory multiple sclerosis patients

Fractures resulting from osteoporosis are a major cause of morbidity and mortality in the developed world. People with multiple sclerosis experience reduced mobility and are susceptible to falls. Glucocorticoid use and reduced mobility are known risk factors for osteoporosis. This paper is a review of osteoporosis in people with multiple sclerosis, looking at its prevalence, risk factors and possible mechanisms. We also review management guidelines for osteoporosis in the general population and use these to propose guidelines for osteoporosis management amongst multiple sclerosis patients. A number of studies have examined the incidence of reduced bone mineral density amongst people with multiple sclerosis; the majority provide convincing evidence that bone mineral density is significantly reduced in multiple sclerosis patients. The most significant risk factors appear to arise from the chronic disease process of multiple sclerosis and not from glucocorticoid use. There are currently no guidelines or consensus as how best to treat osteoporosis amongst multiple sclerosis patients despite their being at an increased risk. We propose an algorithm for the screening and treatment of osteoporosis in people with multiple sclerosis.

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THE RELATIONSHIP BONE MINERAL DENSITY AND HIGH-DOSE SHORT-TERM CORTICOSTEROID THERAPY IN MULTIPLE SCLEROSIS PATIENTS

SANAMED ◽

10.24125/sanamed.v15i3.454 ◽

2020 ◽

Vol 15 (3) ◽

pp. 293

Author(s):

Pinar Bekdik Sirinocak ◽

Neslihan Eskut ◽

Ufuk Sener ◽

Yasar Zorlu

Keyword(s):

Multiple Sclerosis ◽

Bone Mineral Density ◽

Corticosteroid Therapy ◽

Bone Mineral ◽

High Dose ◽

Mineral Density ◽

Short Term ◽

Multiple Sclerosis Patients ◽

The Relationship

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The effect of interferon beta 1B on bone mineral density in multiple sclerosis patients

Journal of Back and Musculoskeletal Rehabilitation ◽

10.3233/bmr-2010-0244 ◽

2010 ◽

Vol 23 (1) ◽

pp. 25-29 ◽

Cited By ~ 7

Author(s):

Asuman Orhan Varoglu ◽

Erhan Varoglu ◽

Rezzan Bayraktar ◽

Recep Aygul ◽

Hizir Ulvi ◽

...

Keyword(s):

Multiple Sclerosis ◽

Bone Mineral Density ◽

Bone Mineral ◽

Interferon Beta ◽

Mineral Density ◽

Multiple Sclerosis Patients

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3 Bone Mineral Density Assessment of Lower Limb in Multiple Sclerosis Patients

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2008.07.009 ◽

2009 ◽

Vol 12 (1) ◽

pp. 103-104

Author(s):

N.I. Fezoulidis ◽

N. Tassiopoulos ◽

P.J. Papadaki ◽

D. Stergiou ◽

A. Papadimitriou ◽

...

Keyword(s):

Multiple Sclerosis ◽

Bone Mineral Density ◽

Bone Mineral ◽

Lower Limb ◽

Mineral Density ◽

Bone Mineral Density Assessment ◽

Multiple Sclerosis Patients ◽

Density Assessment

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Lack of Association between Pulse Steroid Therapy and Bone Mineral Density in Patients with Multiple Sclerosis

Multiple Sclerosis International ◽

10.1155/2016/5794910 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Serap Zengin Karahan ◽

Cavit Boz ◽

Sevgi Kilic ◽

Nuray Can Usta ◽

Mehmet Ozmenoglu ◽

...

Keyword(s):

Multiple Sclerosis ◽

Bone Mineral Density ◽

Lumbar Spine ◽

Femoral Neck ◽

Bone Mineral ◽

Steroid Therapy ◽

Negative Relationship ◽

High Dose ◽

Mineral Density ◽

Factors Affecting

Multiple sclerosis (MS) has been associated with reduced bone mineral density (BMD). The purpose of this study was to determine the possible factors affecting BMD in patients with MS. We included consecutive 155 patients with MS and 90 age- and sex-matched control subjects. Patients with MS exhibited significantly lowerT-scores andZ-scores in the femoral neck and trochanter compared to the controls. Ninety-four (61%) patients had reduced bone mass in either the lumbar spine or the femoral neck; of these, 64 (41.3%) had osteopenia and 30 (19.4%) had osteoporosis. The main factors affecting BMD were disability, duration of MS, and smoking. There was a negative relationship between femoral BMD and EDSS and disease duration. No association with lumbar BMD was determined. There were no correlations between BMD at any anatomic region and cumulative corticosteroid dose. BMD is significantly lower in patients with MS than in healthy controls. Reduced BMD in MS is mainly associated with disability and duration of the disease. Short courses of high dose steroid therapy did not result in an obvious negative impact on BMD in the lumbar spine and femoral neck in patients with MS.

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