Targeted delivery and controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon nanotubes

2016 ◽  
Vol 68 ◽  
pp. 579-584 ◽  
Author(s):  
Baodan Yu ◽  
Li Tan ◽  
Runhui Zheng ◽  
Huo Tan ◽  
Lixia Zheng
Keyword(s):  
Lung Cancer ◽  
Carbon Nanotubes ◽  
Controlled Release ◽  
Targeted Delivery ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Controlled release and targeted delivery to cancer cells of doxorubicin from polysaccharide-functionalised single-walled carbon nanotubes

2015 ◽  
Vol 3 (9) ◽  
pp. 1846-1855 ◽  
Author(s):  
Yunfei Mo ◽  
Haowen Wang ◽  
Jianghui Liu ◽  
Yong Lan ◽  
Rui Guo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Water Solubility ◽  
Single Walled Carbon Nanotubes ◽  
Innovative Drug ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Carboxyl single-walled carbon nanotubes (SWNTs) were used to construct an innovative drug delivery system by modification with chitosan (CHI) to enhance water solubility and biocompatibility.

scholarly journals Octa-ammonium POSS-conjugated single-walled carbon nanotubes as vehicles for targeted delivery of paclitaxel

Nano Reviews ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 28297 ◽  
Author(s):  
Naghmeh Naderi ◽  
Seyed Y. Madani ◽  
Afshin Mosahebi ◽  
Alexander M. Seifalian
Keyword(s):  
Carbon Nanotubes ◽  
Targeted Delivery ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

scholarly journals Targeted Delivery of Mannosylated Nanoparticles Improve Prophylactic Efficacy of Immersion Vaccine against Fish Viral Disease

Vaccines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 87 ◽  
Author(s):  
Bin Zhu ◽  
Chen Zhang ◽  
Zhao Zhao ◽  
Gao-Xue Wang
Keyword(s):  
Carbon Nanotubes ◽  
Immune Responses ◽  
Delivery System ◽  
Targeted Delivery ◽  
Juvenile Fish ◽  
Single Walled Carbon Nanotubes ◽  
Viral Disease ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Immersion vaccination is considered as the most effective method for juvenile fish in preventing viral disease, due to its convenience for mass vaccination and stress-free administration. However, immune responses following immersion vaccination are generally less robust and of shorter duration than those induced through intraperitoneal injection. Herein, to improve the efficacy of the immersion vaccine, we constructed a targeted single-walled carbon nanotubes-based immersion vaccine delivery system (CNTs-M-VP7), the surface of which are modified with mannose to allow antigen-presenting cells’ (APCs) targeting. The targeting ability of CNTs-M-VP7 was confirmed in vivo and in vitro. Critically, this immersion CNTs-M-VP7 vaccine could cross into the fish body through mucosal tissues (skin, gill, and intestine), and then present to immune-related tissues. Moreover, CNTs-M-VP7 could significantly induce the maturation and presenting process of APCs, which would then trigger robust immune responses. Altogether, this study demonstrates that the single-walled carbon nanotubes (SWCNTs)-based targeted nanovaccine delivery system shows the potential to be an effective prophylactic against fish viral disease.

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