Investigation on the microstructure, mechanical properties, in vitro degradation behavior and biocompatibility of newly developed Zn-0.8%Li-(Mg, Ag) alloys for guided bone regeneration

2019 ◽  
Vol 99 ◽  
pp. 1021-1034 ◽  
Author(s):  
Yu Zhang ◽  
Yang Yan ◽  
Xuemei Xu ◽  
Yujiao Lu ◽  
Liangjian Chen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Degradation Behavior ◽  
In Vitro Degradation

scholarly journals Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1797
Author(s):  
Manuel Toledano ◽  
Marta Vallecillo-Rivas ◽  
María T. Osorio ◽  
Esther Muñoz-Soto ◽  
Manuel Toledano-Osorio ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Bone Repair ◽  
Complex Modulus ◽  
Bacterial Colonization ◽  
Guided Bone Regeneration ◽  
M2 Macrophage

Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in bone healing and regeneration is necessary. The aim of the present study is to state the effect of doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken, focusing on the antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity, bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility, strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis, angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted pro-healing phenotypes.

scholarly journals In Vitro Degradation of Poly(caprolactone)/nHA Composites

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Esperanza Díaz ◽  
Iban Sandonis ◽  
María Blanca Valle
Keyword(s):  
Mechanical Properties ◽  
Degradation Products ◽  
Degradation Process ◽  
Porous Scaffolds ◽  
Degradation Behavior ◽  
Compressive Properties ◽  
Composite Scaffolds ◽  
In Vitro Degradation ◽  
Poly Caprolactone

The degradation behavior and mechanical properties of polycaprolactone/nanohydroxyapatite composite scaffolds are studied in phosphate buffered solution (PBS), at 37°C, over 16 weeks. Under scanning electron microscopy (SEM), it was observed that the longer the porous scaffolds remained in the PBS, the more significant the thickening of the pore walls of the scaffold morphology was. A decrease in the compressive properties, such as the modulus and the strength of the PCL/nHA composite scaffolds, was observed as the degradation experiment progressed. Samples with high nHA concentrations degraded more significantly in comparison to those with a lower content. Pure PCL retained its mechanical properties comparatively well in the study over the period of degradation. After the twelfth week, the results obtained by GPC analysis indicated a significant reduction in their molecular weight. The addition of nHA particles to the scaffolds accelerated the weight loss of the composites and increased their capacity to absorb water during the initial degradation process. The addition of these particles also affected the degradation behavior of the composite scaffolds, although they were not effective at compensating the decrease in pH prompted by the degradation products of the PCL.

Mechanical properties, in vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn–1.2Mg alloy for biodegradable implants

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86410-86419 ◽  
Author(s):  
Chao Shen ◽  
Xiwei Liu ◽  
Bo Fan ◽  
Pingheng Lan ◽  
Feiyu Zhou ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biodegradable Implants ◽  
Degradation Behavior ◽  
Biodegradable Material ◽  
In Vitro Degradation

The microstructure, mechanical properties, in vitro degradation behavior, in vitro hemocompatibility and cytotoxicity were tested to investigate Zn–1.2Mg alloy as a new biodegradable material.

Microstructure, mechanical properties and in vitro degradation behavior of novel Zn-Cu-Fe alloys

2017 ◽  
Vol 134 ◽  
pp. 114-122 ◽  
Author(s):  
Rui Yue ◽  
Hua Huang ◽  
Guizhou Ke ◽  
Hua Zhang ◽  
Jia Pei ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Degradation Behavior ◽  
In Vitro Degradation ◽  
Fe Alloys
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