A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release

Nano Energy ◽  
2019 ◽  
Vol 66 ◽  
pp. 104120 ◽  
Author(s):  
Qinghua Cui ◽  
Thanh-Ha Le ◽  
Yu-Jung Lin ◽  
Yang-Bao Miao ◽  
I-Ting Sung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Self Powered

Controlled and Programmable Drug Delivery Using a Self-Powered MEMS Device

2007 ◽  
Author(s):  
Asheesh Divetia ◽  
Nolan Yoshimura ◽  
Guann-Pynn Li ◽  
Baruch D. Kuppermann ◽  
Mark Bachman
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Microelectromechanical Systems ◽  
Delivery Device ◽  
External Stimulation ◽  
Drug Delivery Device ◽  
Surrounding Environment ◽  
External Power ◽  
Pulsatile Drug Delivery ◽  
Self Powered

Controlled and targeted drug delivery systems have gained a lot of interest as they offer numerous benefits such as precise dosing, reduced side-effects and increased patient compliance. We have designed a microelectromechanical systems (MEMS) drug delivery device that is capable of releasing drugs in a controlled and programmable manner. This self-powered device does not require any external stimulation or control to achieve pulsatile release of drugs. The device consists of multiple reservoirs containing the drug embedded together with a water-swellable polymer. The swelling of the polymer upon contact with water and the resulting pressure generated is used as an actuation mechanism to release drugs from each reservoir. The programmable release of the drug from the device is achieved by controlling the diffusion rate of water from the surrounding environment into each reservoir. The drug is released from the reservoir when the swellable polymer absorbs water from the environment and generates enough pressure to break an overlying rupturable membrane. We have demonstrated that controlled and pulsatile drug delivery can be achieved using this delivery device, without any external power or control.

scholarly journals Novel Drug Delivery Device Using Silicone: Controlled Release of Insoluble Drugs or Two Kinds of Water-Soluble Drugs

2003 ◽  
Vol 51 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Masako Kajihara ◽  
Toshihiko Sugie ◽  
Hiroo Maeda ◽  
Akihiko Sano ◽  
Keiji Fujioka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Water Soluble ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Water Soluble Drugs ◽  
Insoluble Drugs ◽  
Novel Drug

An electrochemical intraocular drug delivery device

2008 ◽  
Vol 143 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Po-Ying Li ◽  
Jason Shih ◽  
Ronalee Lo ◽  
Saloomeh Saati ◽  
Rajat Agrawal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Intraocular Drug Delivery

Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers

2007 ◽  
Vol 9 (6) ◽  
pp. 845-853 ◽  
Author(s):  
Won Hyoung Ryu ◽  
Murty Vyakarnam ◽  
Ralph S. Greco ◽  
Fritz B. Prinz ◽  
Rainer J. Fasching
Keyword(s):  
Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Micro Structuring

In vivo tolerance and kinetics of a novel ocular drug delivery device

2006 ◽  
Vol 116 (2) ◽  
pp. e47-e49 ◽  
Author(s):  
R.T. Pijls ◽  
H.H.L. Hanssen ◽  
R.M.M.A. Nuijts ◽  
G.W. Daube ◽  
L.H. Koole
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Kinetics Of
Sign in / Sign up

Export Citation Format

Share Document