Eradication of Ventricular Assist Device Driveline Infection in Paediatric Patients with Taurolidine

Ventricular assist devices (VADs) are used to provide mechanical circulatory support to patients with end-stage heart failure. The driveline connecting the external power source to the pump(s) of the intra-corporal VAD breaches the protective skin barrier and provides a track for microbes to invade the interior of the patient’s body. Driveline infection constitutes a major and potentially fatal vulnerability of VAD therapy. Driveline infection cannot traditionally be salvaged and requires the extraction of the entire VAD system. We report here the successful eradication of a VAD driveline infection with a taurolidine-containing antimicrobial solution used for preventing the infection of cardiac implantable electronic devices. If replicated in more cases, the novel treatment concept described here may provide a valuable alternative management strategy of salvage rather than explantation for VAD driveline infection.

Pneumatologi Lukas: Karya Roh Kudus dan Implikasinya untuk Orang Percaya Era Postmodern

Lukas memberikan porsi tertinggi terkait dengan tema Roh Kudus. ­ Oleh karena itu, pembahasan mengenai pneumatology. Lukas harus diarahkan kepada apa yang sudah, sedang, dan akan dikerjakan atas gereja dan seluruh orang percaya yang adalah tubuh Kristus. Hasil dari karya itu akan berdampak kepada kehidupan jemaat yang bertumbuh secara kualitas dan kuantitas. Namun dewasa ini, Roh Kudus banyak dipandang sebagai kuasa dari luar yang membuat pelayanan seseorang berhasil. Tujuan dari penelitian ini adalah untuk mengungkap kembali karya Roh Kudus dalam hidup orang percaya sebagai pribadi dan tubuh Kristus. Metode penelitian yang digunakan adalah kualitatif deskriptif. Hasil penelitian menunjukkan bahwa pneumatologi Lukas mengarahkan setiap orang percaya masa kini dapat memanifestasikan karya dan kasih Roh Kudus bagi setiap orang. Dengan mengerjakan ini, maka relativitas dunia dalam memahami kasih Tuhan dapat terlihat jelas dalam cara hidup orang percaya yang menjaga harmonisasi seluruh ciptaan.Luke gives the highest portion related to the theme of the Holy Spirit. The Holy Spirit is the person who begins, works, and ends God's work in this world. The results of this work will impact the congregation's life, which grows both in quality and quantity. Nevertheless, the Holy Spirit is widely seen as an external power that makes one's ministry successful. The purpose of this research is to reveal the work of the Holy Spirit in the lives of believers as the person and body of Christ again. The research method used is descriptive qualitative. The results show that Luke's pneumatology directs every believer today to manifest the work and love of the Holy Spirit for everyone. By doing this, the relativity of the world in understanding God's love can see in the way of life of believers who maintain the harmonization of all creation.

Comparison of crossover and jab step start techniques in sprinting for football and handball players

There are two techniques for a lateral sprint start: crossover (CS) and jab step (JS) starts. This study aimed to elucidate the difference in the CS and JS starts in terms of sprint performance and leg kinetics in athletes from ball-and-goal type sports (e.g. soccer and handball). Nineteen male athletes performed CS and JS starts, during which their motion and the force they applied to the ground were simultaneously recorded using a motion-capture system and two force platforms. The results showed that, although 5-m time via video analysis did not differ between CS and JS starts, forward velocity of centre of gravity (CG) and normalised average horizontal external power were greater for the JS start than the CS start. From waveform analysis, greater positive joint power in the sagittal plane leading to greater positive work in the JS start were found in the first three quarters of the push-off phase for rear hip extension and in the subsequent push-off phase for rear ankle plantar flexion. In conclusion, the results suggest that the JS start is superior to the CS start for start quickness, though the gains in the start did not appear to transfer to the 5-m performance. Moreover, greater positive joint power in the first three quarters of the push-off phase for the rear hip extension and in the subsequent push-off phase for the rear ankle plantar flexion were considered to be important contributing factors to the better performance of the JS start.

Flow Control in Passive 3D Paper-Based Microfluidic Pump by Variable Porosity

Active pumps are often used in microfluidic devices for programmable fluid flowrate in a microchannel. Active pumps have some drawbacks due to their large size and requirement of external power. To overcome them, a new class of passive pumps based on capillary action in cellulose material, known as paper-based microfluidic pumps, has recently been explored. In this study, fluid flow in 3D paper-based pumps was investigated using flowrate measurements in microchannels. In order to develop 3D cylindrical pumps, Whatman filter paper grade 1 was shredded, mixed with water, molded and dried. The patterned serpentine channel was created using a CO2 Laser Cutting/Engraving machine. The 3D paper-based pump was integrated with microfluidic channel. The effect of paper pumps of different porosities on the fluid flowrate through a serpentine microchannel was investigated. It was found that flowrate of the fluid flowing through the channel increases with an increase in the pump’s porosity. Moreover, these pumps have the ability to transport larger volumes of liquid with improved flowrate, programmability and control, in addition to being inexpensive and simple to design and fabricate. These 3D pumps will help researchers move closer to developing an effective miniaturized diagnostic platform for point-of-care (POC) diagnostic applications.

A Novel Approach of Synchronization of Microgrid with a Power System of Limited Capacity

Currently, active networks called microgrids are formed on the basis of local power supply systems with a small share of distributed generation. Microgrids operating in an island mode, in some cases, have the ability to transfer electricity excess to an external network leading to a synchronization requirement; thus, the optimization task in terms of the system’s synchronization must be considered. This paper proposes a method for obtaining synchronization between microgrids and power systems of limited capacity based on a passive synchronization algorithm, allowing us to connect a microgrid to an external power system with a minimum impact moment on the shaft of the generating equipment. The algorithm application was demonstrated by considering a real-life object in Tajikistan. The simulation was carried out on RastrWin3. The obtained results show that the microgrid generator is connected to an external power system at an angle of 0.3° and a power surge of 29 kW, unlike the classical synchronization algorithm with an angle of 6.8° and a power surge of 154 kW (a reduction of the shock moment by more than five times). The proposed synchronization method allows us to reduce the resource consumption of the generating equipment and increase the reliability and efficiency of the functioning units of the examined power system.

Two-Channel VO2 Memory Meta-Device for Terahertz Waves

Vanadium oxide (VO2), as one of the classical strongly correlated oxides with a reversible and sharp insulator-metal transition (IMT), enables many applications in dynamic terahertz (THz) wave control. Recently, due to the inherent phase transition hysteresis feature, VO2 has shown favorable application prospects in memory-related devices once combined with metamaterials or metasurfaces. However, to date, VO2-based memory meta-devices are usually in a single-channel read/write mode, which limits their storage capacity and speed. In this paper, we propose a reconfigurable meta-memory based on VO2, which favors a two-channel read/write mode. Our design consists of a pair of large and small split-ring resonators, and the corresponding VO2 patterns are embedded in the gap locations. By controlling the external power supply, the two operation bands can be controlled independently to achieve at least four amplitude states, including “00”, “01”, “10”, and “11”, which results in a two-channel storage function. In addition, our research may provide prospective applications in fields such as THz switching, photon storage, and THz communication systems in the future.

Osmotically Enabled Wearable Patch for Sweat Harvesting and Lactate Quantification

Lactate is an essential biomarker for determining the health of the muscles and oxidative stress levels in the human body. However, most of the currently available sweat lactate monitoring devices require external power, cannot measure lactate under low sweat rates (such as in humans at rest), and do not provide adequate information about the relationship between sweat and blood lactate levels. Here, we discuss the on-skin operation of our recently developed wearable sweat sampling patch. The patch combines osmosis (using hydrogel discs) and capillary action (using paper microfluidic channel) for long-term sweat withdrawal and management. When subjects are at rest, the hydrogel disc can withdraw fluid from the skin via osmosis and deliver it to the paper. The lactate amount in the fluid is determined using a colorimetric assay. During active sweating (e.g., exercise), the paper can harvest sweat even in the absence of the hydrogel patch. The captured fluid contains lactate, which we quantify using a colorimetric assay. The measurements show the that the total number of moles of lactate in sweat is correlated to sweat rate. Lactate concentrations in sweat and blood correlate well only during high-intensity exercise. Hence, sweat appears to be a suitable biofluid for lactate quantification. Overall, this wearable patch holds the potential of providing a comprehensive analysis of sweat lactate trends in the human body.

Analysis of a Cam-Follower Mechanism for a Passive Parallel Lower Limb Exoskeleton

This project focused on the implementation of a novel cam-follower mechanism that was deemed to have good potential for practical application into a passive lower limb exoskeleton to determine its effectiveness in reducing the energy requirement of the user and its ability to match the walking gait of the user. The design of this novel-cam follower mechanism is inspired by the retractable mechanism of a ballpen. The cam follower mechanism was incorporated into a passive lower limb exoskeleton that was available prior to the study. Passive exoskeletons are intended to augment the load carrying capacity of the user through mechanical means instead of relying on external power. The walking gait study was conducted using physical testing. The mechanism was found to cause the user to bend below his natural centre of gravity a couple of times throughout the walking cycle. The user also had to stabilize himself from being rocked from side to side. Energy calculations were likewise conducted to investigate the energy consumption for a full cycle. The interchange among gravitational potential energy, spring potential energy and kinetic energy of the mechanism for a full walking cycle did not indicate possible advantage for the user.