scholarly journals Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies

2021 ◽  
pp. 105542
Author(s):  
F. Biyong Essi ◽  
Tremblay Cyntia ◽  
Leclerc Manon ◽  
Caron Vicky ◽  
Alfos Serge ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin A ◽  
Dietary Vitamin ◽  
Preclinical Studies ◽  
Retinoid X Receptors ◽  
X Receptors

scholarly journals DISPARITIES IN ALZHEIMER’S DISEASE: THE ROLE OF REPEATED ANESTHETIC AND SURGICAL EXPOSURE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S426-S427
Author(s):  
Miklos D Kertai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Surgical Procedures ◽  
Environmental Exposures ◽  
The Elderly ◽  
Noncardiac Surgery ◽  
Surgical Patients ◽  
Preclinical Studies ◽  
The Us

Abstract Annually, there are 7 million patients > 65 years who undergo noncardiac surgery in the US. This number is expected to increase by 30% over the next 3 decades, and given the prevalence of surgically correctable comorbidities, the elderly will continue to undergo multiple surgical procedures. Currently, it is unclear what factors initiate or promote the development of Alzheimer’s disease (AD). Preclinical studies suggest that exposure to anesthesia and/or surgery could be one of the environmental exposures that increase AD risk through neuroinflammation and neuroapoptosis. However, previous studies indicated substantial disparities in AD risk by gender, ethnicity, and race, but failed to explore the role of anesthesia and/or surgery exposure in the risk for AD. This presentation will review the role of disparities and anesthesia and/or surgery exposure in the risk for AD in elderly surgical patients.

scholarly journals Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease

2019 ◽  
Vol 176 (18) ◽  
pp. 3599-3610 ◽  
Author(s):  
Nicholas F. Fitz ◽  
Kyong Nyon Nam ◽  
Radosveta Koldamova ◽  
Iliya Lefterov
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nuclear Receptors ◽  
Therapeutic Targeting ◽  
Retinoid X Receptors ◽  
X Receptors

scholarly journals Systematic review of the literature on vitamin A and memory

2012 ◽  
Vol 6 (4) ◽  
pp. 219-222 ◽  
Author(s):  
Yara Dadalti Fragoso ◽  
Niklas Söderberg Campos ◽  
Breno Faria Tenrreiro ◽  
Fernanda Jussio Guillen
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin A ◽  
Evidence Based ◽  
Review Of The Literature ◽  
Vitamin A Supplementation ◽  
Treatment And Prevention ◽  
The Subject

ABSTRACT Background: Over the last 30 years, a variety of studies reporting the effects of vitamin A on memory have been published. Objective: To perform a rigorous systematic review of the literature on vitamin A and memory in order to organize evidence-based data on the subject. Methods: Four authors carried out the systematic review in accordance with strict guidelines. The terms "vitamin A" OR "retinol" OR "retinoic acid" AND "memory" OR "cognition" OR "Alzheimer" were searched in virtually all medical research databases. Results: From 236 studies containing the key words, 44 were selected for this review, numbering 10 reviews and 34 original articles. Most studies used animal models for studying vitamin A and cognition. Birds, mice and rats were more frequently employed whereas human studies accounted for only two reports on brain tissue from autopsies and one on the role of isotretinoin in cognition among individuals taking this medication to treat acne. Conclusion: Vitamin A may be an important and viable complement in the treatment and prevention of Alzheimer's disease. Clinical trials are imperative and, at present, there is no evidence-based data to recommend vitamin A supplementation for the prevention or treatment of Alzheimer's disease.

scholarly journals Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies

2017 ◽  
Vol 58 (7) ◽  
pp. 1267-1281 ◽  
Author(s):  
Mitsuru Shinohara ◽  
Masaya Tachibana ◽  
Takahisa Kanekiyo ◽  
Guojun Bu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Preclinical Studies

Dissecting the role of Corticotropin-releasing hormone receptor type 1 in Alzheimer's Disease

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
K Lerche ◽  
M Willem ◽  
K Kleinknecht ◽  
C Romberg ◽  
U Konietzko ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hormone Receptor ◽  
Receptor Type ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Role of melatonin in regulating neurogenesis: Implications for the neurodegenerative pathology and analogous therapeutics for Alzheimer’s disease

2020 ◽  
Vol 3 (2) ◽  
pp. 216-242 ◽  
Author(s):  
Mayuri Shukla ◽  
Areechun Sotthibundhu ◽  
Piyarat Govitrapong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Adult Neurogenesis ◽  
Adult Brain ◽  
Therapeutic Approaches ◽  
Therapeutic Implications ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Progenitor Cell Proliferation

The revelation of adult brain exhibiting neurogenesis has established that the brain possesses great plasticity and that neurons could be spawned in the neurogenic zones where hippocampal adult neurogenesis attributes to learning and memory processes. With strong implications in brain functional homeostasis, aging and cognition, various aspects of adult neurogenesis reveal exuberant mechanistic associations thereby further aiding in facilitating the therapeutic approaches regarding the development of neurodegenerative processes in Alzheimer’s Disease (AD). Impaired neurogenesis has been significantly evident in AD with compromised hippocampal function and cognitive deficits. Melatonin the pineal indolamine augments neurogenesis and has been linked to AD development as its levels are compromised with disease progression. Here, in this review, we discuss and appraise the mechanisms via which melatonin regulates neurogenesis in pathophysiological conditions which would unravel the molecular basis in such conditions and its role in endogenous brain repair. Also, its components as key regulators of neural stem and progenitor cell proliferation and differentiation in the embryonic and adult brain would aid in accentuating the therapeutic implications of this indoleamine in line of prevention and treatment of AD.   

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