Simultaneous changes in secretory amyloid precursor protein and β-amyloid peptide release from rat hippocampus by activation of muscarinic receptors

2003 ◽  
Vol 352 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Yu Qiu ◽  
Xing-Jun Wu ◽  
Hong-Zhuan Chen
Keyword(s):  
Amyloid Precursor Protein ◽  
Muscarinic Receptors ◽  
Precursor Protein ◽  
Rat Hippocampus ◽  
Amyloid Peptide ◽  
Peptide Release ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1

2003 ◽  
Vol 278 (51) ◽  
pp. 51100-51107 ◽  
Author(s):  
Yang Chang ◽  
Giuseppina Tesco ◽  
William J. Jeong ◽  
Loren Lindsley ◽  
Elizabeth A. Eckman ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Protein C ◽  
Precursor Protein ◽  
Amyloid Peptide ◽  
Terminal Fragment ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Cytotoxic Fragment of Amyloid Precursor Protein Accumulates in Hippocampus after Global Forebrain Ischemia

1996 ◽  
Vol 16 (6) ◽  
pp. 1219-1223 ◽  
Author(s):  
Masayuki Yokota ◽  
Takaomi C. Saido ◽  
Eiichi Tani ◽  
Ikuya Yamaura ◽  
Nobutaka Minami
Keyword(s):  
Amyloid Precursor Protein ◽  
Pyramidal Neurons ◽  
Granule Cells ◽  
Precursor Protein ◽  
Amyloid Peptide ◽  
Forebrain Ischemia ◽  
Ischemic Insult ◽  
Dentate Granule Cells ◽  
Β Amyloid ◽  
Β Amyloid Peptide

We developed an antibody specific to β-amyloid precursor protein (βAPP) fragments possessing the exact amino terminus of the β-amyloid peptide and examined its induction in postischemic hippocampus. In control hippocampus, this APP fragment was lightly observed in pyramidal neurons of CA sectors and dentate granule cells. Transient forebrain ischemia enhanced accumulation of the APP fragment in CA1 pyramidal neurons. Seven days after the ischemia, while the APP fragment was still observed in dentate granule cells and CA3 neurons, it disappeared in dead CA1 neurons. While astrocytes did not show in any immunoreactivity throughout the experiment, those in the CA1 sector showed moderate immunoreactivity 7 days after the ischemia. The APP fragment has a cytotoxic effect on cultured neurons. These results suggest that the accumulation of the cytotoxic APP fragment in CA1 neurons may play a role in the development of delayed neuronal death after the ischemic insult.

scholarly journals β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice

2011 ◽  
Vol 286 (39) ◽  
pp. 33747-33758 ◽  
Author(s):  
Heinke Schieb ◽  
Hartmut Kratzin ◽  
Olaf Jahn ◽  
Wiebke Möbius ◽  
Sabine Rabe ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide

2017 ◽  
Vol 292 (50) ◽  
pp. 20669-20682 ◽  
Author(s):  
Erwan Lanchec ◽  
Antoine Désilets ◽  
François Béliveau ◽  
Anthony Flamier ◽  
Shaimaa Mahmoud ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Serine Protease ◽  
Precursor Protein ◽  
Amyloid Peptide ◽  
Type Ii ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Transmembrane Serine Protease
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