Recombinant human erythropoietin offers neuroprotection through inducing endogenous erythropoietin receptor and neuroglobin in a neonatal rat model of periventricular white matter damage

2017 ◽  
Vol 650 ◽  
pp. 12-17 ◽  
Author(s):  
Lihua Zhu ◽  
Li Huang ◽  
Quan Wen ◽  
Ting Wang ◽  
Lixing Qiao ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Recombinant Human Erythropoietin ◽  
Erythropoietin Receptor ◽  
Neonatal Rat ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Endogenous Erythropoietin ◽  
Human Erythropoietin ◽  
Neonatal Rat Model

Expression of ephrinB2 and EphB4 in a neonatal rat model of periventricular white matter damage

2015 ◽  
Vol 43 (3) ◽  
Author(s):  
Lihua Zhu ◽  
Lijuan Qian ◽  
Shiyu Wang ◽  
Ting Wang ◽  
Li Jiang
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Vascular System ◽  
Periventricular Leukomalacia ◽  
Vascular Supply ◽  
Neonatal Rat ◽  
Cerebral White Matter ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Hypoxia Ischemia

AbstractPeriventricular white matter damage (PWMD), also termed periventricular leukomalacia, is the predominant neurologic lesion in preterm infants. It appears to relate in part to the development of the vascular supply to the cerebral white matter. We investigated whether, in case of severe hypoxia-ischemia, the vascular system would be subject to severe damage or remodeled.To evaluate microvessel density (MVD) and the use of ephrinB2 and its receptor EphB4 to mark arterioles and venules to establish the correct anatomic assignment of the remodeled vessels in a hypoxia-induced PWMD rat model.Postnatal day 3 rats underwent permanent ligation of the right common carotid artery followed by 6% OCompared with sham rats, MVD, ephrinB2 and EphB4 levels were higher in the brains of hypoxic-ischemic rats. Similar percentages of vessels expressed ephrinB2 and EphB4 in sham rats, but expression of ephrinB2 was greater in brains injured by hypoxia-ischemia.Following hypoxic-ischemic injury to the rat brain, microvessels were remodeled and more arterioles than venules were acquired.

Recombinant Human Erythropoietin Augments Angiogenic Responses in a Neonatal Rat Model of Cerebral Unilateral Hypoxia-Ischemia

Neonatology ◽  
2014 ◽  
Vol 106 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Lihua Zhu ◽  
Xiang Bai ◽  
Shiyu Wang ◽  
Yan Hu ◽  
Ting Wang ◽  
...  
Keyword(s):  
Rat Model ◽  
Recombinant Human Erythropoietin ◽  
Neonatal Rat ◽  
Human Erythropoietin ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Model

scholarly journals Characterization of White Matter Injury in a Hypoxic-Ischemic Neonatal Rat Model by Diffusion Tensor MRI

Stroke ◽  
2008 ◽  
Vol 39 (8) ◽  
pp. 2348-2353 ◽  
Author(s):  
Silun Wang ◽  
Ed X. Wu ◽  
Chung Nga Tam ◽  
Ho-Fai Lau ◽  
Pik-To Cheung ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Diffusion Tensor ◽  
White Matter Injury ◽  
Neonatal Rat ◽  
Diffusion Tensor Mri ◽  
Neonatal Rat Model

scholarly journals Assessing therapeutic response non-invasively in a neonatal rat model of acute inflammatory white matter injury using high-field MRI

2019 ◽  
Vol 81 ◽  
pp. 348-360 ◽  
Author(s):  
Wyston C. Pierre ◽  
Luis Akakpo ◽  
Irène Londono ◽  
Philippe Pouliot ◽  
Sylvain Chemtob ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Model ◽  
High Field ◽  
Therapeutic Response ◽  
White Matter Injury ◽  
Neonatal Rat ◽  
High Field Mri ◽  
Neonatal Rat Model

scholarly journals Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis

2012 ◽  
Vol 47 (9) ◽  
pp. 1652-1657 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Sadık Yurttutan ◽  
Fatma Nur Sarı ◽  
Bulent Uysal ◽  
Hatice Germen Unverdi ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Neonatal Rat ◽  
Antioxidant Effects ◽  
Neonatal Rat Model
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