Mechanism of neuroaxonal degeneration: from molecular signaling to therapeutic applications

2019 ◽  
Vol 139 ◽  
pp. 1-2
Author(s):  
Toshiyuki Araki ◽  
Toshihide Yamashita
Keyword(s):  
Molecular Signaling ◽  
Therapeutic Applications ◽  
Neuroaxonal Degeneration

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Molecular Signaling in Bone Regeneration

2007 ◽  
Vol 17 (2) ◽  
pp. 87-102 ◽  
Author(s):  
H. Bahar ◽  
Dafna Benayahu ◽  
A. Yaffe ◽  
I. Binderman
Keyword(s):  
Bone Regeneration ◽  
Molecular Signaling

Pharmacology and Therapeutic Applications of A1 Adenosine Receptor Ligands

2003 ◽  
Vol 3 (4) ◽  
pp. 369-385 ◽  
Author(s):  
Arvinder Dhalla ◽  
John Shryock ◽  
Revati Shreeniwas ◽  
Luiz Belardinelli
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
A1 Adenosine Receptor ◽  
Therapeutic Applications ◽  
Adenosine Receptor Ligands

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

2020 ◽  
Vol 16 ◽  
Author(s):  
Vitor F. Ferreira ◽  
Alcione S. de Carvalho ◽  
Patricia G. Ferreira ◽  
Carolina G. S. Lima ◽  
Fernando de C. da Silva
Keyword(s):  
Drug Combination ◽  
Medicinal Chemistry ◽  
Pharmaceutical Market ◽  
Important Class ◽  
Therapeutic Applications ◽  
New Applications ◽  
Pharmaceutical Uses

Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases. Objective: The aim of this review was to provide an overview on the quinones that have become drugs for several therapeutic applications. Method: We have comprehensively and critically discussed all the information available in the literature about quinonebased drugs. Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses. Conclusion: The number of studies related to quinone drugs for different pharmaceutical uses shows that the interest in new applications still increasing in recent years.

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