Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation

2021 ◽  
Author(s):  
Risa Kajiwara ◽  
Shiro Nakamura ◽  
Keiko Ikeda ◽  
Hiroshi Onimaru ◽  
Atsushi Yoshida ◽  
...  
Keyword(s):  
Reticular Formation ◽  
Synaptic Connectivity ◽  
Intrinsic Properties

scholarly journals Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons

2021 ◽  
Author(s):  
Yoav Printz ◽  
Pritish Patil ◽  
Mathias Mahn ◽  
Asaf Benjamin ◽  
Anna Litvin ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Cortical Neurons ◽  
Large Scale ◽  
Basolateral Amygdala ◽  
Local Network ◽  
Synaptic Connectivity ◽  
Synaptic Organization ◽  
Intrinsic Properties ◽  
Subcortical Structures ◽  
Prefrontal Cortical

The medial prefrontal cortex (mPFC) mediates a variety of complex cognitive functions via its vast and diverse connections with cortical and subcortical structures. Understanding the patterns of synaptic connectivity that comprise the mPFC local network is crucial for deciphering how this circuit processes information and relays it to downstream structures. To elucidate the synaptic organization of the mPFC, we developed a high-throughput optogenetic method for mapping large-scale functional synaptic connectivity. We show that mPFC neurons that project to the basolateral amygdala display unique spatial patterns of local-circuit synaptic connectivity within the mPFC, which distinguish them from the general mPFC cell population. Moreover, the intrinsic properties of the postsynaptic mPFC cell and anatomical position of both cells jointly account for ~7.5% of the variation in probability of connection between mPFC neurons, with anatomical distance and laminar position explaining most of this fraction in variation. Our findings demonstrate a functional segregation of mPFC excitatory neuron subnetworks, and reveal the factors determining connectivity in the mPFC.

The development of projections and connections from transplanted locust sensory neurons

Development ◽  
1985 ◽  
Vol 85 (1) ◽  
pp. 207-224
Author(s):  
Hilary Anderson
Keyword(s):  
Sensory Neurons ◽  
Axon Growth ◽  
Synaptic Connectivity ◽  
Intrinsic Properties ◽  
Extrinsic Factors ◽  
Head Form ◽  
Stimulation Of

Neurons innervating wind-sensitive hairs on the locust head form characteristic projections and connections within the CNS. These depend on intrinsic properties of the epidermis from which the hair and its neuron are formed (Anderson & Bacon, 1979; Bacon & Anderson, 1984). To investigate further these intrinsic properties and also extrinsic factors involved in guiding axon growth and determining synaptic connectivity, pieces of epidermis from the head were transplanted to the posterior head, prothorax, or mesothorax. Thus wind-sensitive neurons developing from the grafts were caused to grow into foreign parts of the CNS. The neuronal projections from the graft hairs were examined by filling the axons with cobalt, and their connectivity with an identified interneuron, the Tritocerebral Commissure Giant, was examined by recording electrophysiologically the activity of the interneuron during stimulation of the graft hairs. The results show that 1) the neuronal projections are confined to one tract, the median ventral tract, and to one arborization area, the ventral association centre, in all ganglia; 2) in all ganglia, neurons from different epidermal regions preserve their location-specific properties of forming ipsilateral or additional contralateral projections; 3) the extent of their projection in the CNS is not interpretable in terms of intrinsic instructions only; 4) in foreign ganglia, they fail to form connections with their normal target interneuron.

Computer Reconstruction of the Cellular Architecture of the Daphnia Magna Optic Ganglion

1975 ◽  
Vol 33 ◽  
pp. 284-285
Author(s):  
E. R. Macagno ◽  
C. Levinthal
Keyword(s):  
Daphnia Magna ◽  
Genetic Background ◽  
Compound Eye ◽  
Synaptic Connectivity ◽  
Serial Sections ◽  
Cross Sectional ◽  
Small Crustacean ◽  
Optic Ganglion ◽  
Structural Invariance ◽  
High Degree

The optic ganglion of Daphnia Magna, a small crustacean that reproduces parthenogenetically contains about three hundred neurons: 110 neurons in the Lamina or anterior region and about 190 neurons in the Medulla or posterior region. The ganglion lies in the midplane of the organism and shows a high degree of left-right symmetry in its structures. The Lamina neurons form the first projection of the visual output from 176 retinula cells in the compound eye. In order to answer questions about structural invariance under constant genetic background, we have begun to reconstruct in detail the morphology and synaptic connectivity of various neurons in this ganglion from electron micrographs of serial sections (1). The ganglion is sectioned in a dorso-ventra1 direction so as to minimize the cross-sectional area photographed in each section. This area is about 60 μm x 120 μm, and hence most of the ganglion fit in a single 70 mm micrograph at the lowest magnification (685x) available on our Zeiss EM9-S.

God's Being Is in Becoming: An Essay in Theological Idealism

2016 ◽  
Vol 8 (3) ◽  
pp. 145-157
Author(s):  
Hartmut Von Sass
Keyword(s):  
Intrinsic Properties

God’s being is becoming – the title is the thesis. The first section of this paper will be dedicated to the problem of radical historicity in sketching three dogmatic approaches dealing with the relation between God and history. After critically introducing the concept of relational – in contrast to intrinsic – properties in the second section I will apply a revised version of this concept theologically in integrating it into the architecture of Trinitarian thinking. Accordingly, and on that basis, the last section can address the ambivalent as well as precarious question in which sense God’s ultimate being is in real (be) coming.

Quantitative Conditions and Convergent Operations That Are Compatible With the Universe as a Persistent Generator of Successive Simulations

2016 ◽  
Vol 12 (1) ◽  
pp. 4178-4187
Author(s):  
Michael A Persinger ◽  
Stanley A Koren
Keyword(s):  
Structural Organization ◽  
Total Duration ◽  
Human Cognition ◽  
Intrinsic Properties ◽  
Basic Assumptions ◽  
Electron Orbit ◽  
Quantitative Analyses ◽  
Massive Information ◽  
The Universe

                The capacity for computer-like simulations to be generated by massive information processing from electron-spin potentials supports Bostrom’s hypothesis that matter and human cognition might reflect simulations. Quantitative analyses of the basic assumptions indicate the universe may display properties of a simulation where photons behave as pixels and gravitons control the structural organization. The Lorentz solution for the square of the light and entanglement velocities converges with the duration of a single electron orbit that ultimately defines properties of matter. The approximately one trillion potential states within the same space with respect to the final epoch of the universe indicate that a different simulation, each with intrinsic properties, has been and will be generated as a type of tractrix defined by ±2 to 3 days (total duration 5 to 6 days). It may define the causal limits within a simulation. Because of the intrinsic role of photons as the pixel unit, phenomena within which flux densities are enhanced, such as human cognition (particularly dreaming) and the cerebral regions associated with those functions, create the conditions for entanglement or excess correlations between contiguous simulations. The consistent quantitative convergence of operations indicates potential validity for this approach. The emergent solutions offer alternative explanations for the limits of predictions for multivariate phenomena that could be coupled to more distal simulations.

Fluorescence of BODIPY Dyes in Gas Phase at near Ambient Conditions

2020 ◽  
Author(s):  
Kseniya A. Mariewskaya ◽  
Denis Larkin ◽  
Yuri Samoilichenko ◽  
Vladimir Korshun ◽  
Alex Ustinov
Keyword(s):  
Gas Phase ◽  
Molecular Interactions ◽  
Atmospheric Pressure ◽  
Fluorescence Spectra ◽  
Visible Range ◽  
Intrinsic Properties ◽  
Ambient Conditions ◽  
Ideal Model ◽  
Molecular Fluorescence ◽  
Tesla Coil

Molecular fluorescence is a phenomenon that is usually observed in condensed phase. It is strongly affected by molecular interactions. The study of fluorescence spectra in the gas phase can provide a nearly-ideal model for the evaluation of intrinsic properties of the fluorophores. Unfortunately, most conventional fluorophores are not volatile enough to allow study of their fluorescence in the gas phase. Here we report very bright gas phase fluorescence of simple BODIPY dyes that can be readily observed at atmospheric pressure using conventional fluorescence instrumentation. To our knowledge, this is the first example of visible range gas phase fluorescence at near ambient conditions. Evaporation of the dye in vacuum allowed us to demonstrate organic molecular electroluminescence in gas discharge excited by electric field produced by a Tesla coil.

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