PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: Protective role of ascorbic acid

2007 ◽  
Vol 28 (3) ◽  
pp. 490-498 ◽  
Author(s):  
Prabhu Venkataraman ◽  
Raju Muthuvel ◽  
Gunasekaran Krishnamoorthy ◽  
Arumugam Arunkumar ◽  
Muthusami Sridhar ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Oxidative Damage ◽  
Rat Brain ◽  
Brain Regions ◽  
Protective Role ◽  
Aroclor 1254 ◽  
Rat Brain Regions

Protective Role of Cynodon dactylon in Ameliorating the Aluminium-Induced Neurotoxicity in Rat Brain Regions

2011 ◽  
Vol 144 (1-3) ◽  
pp. 843-853 ◽  
Author(s):  
Thangarajan Sumathi ◽  
Chandrasekar Shobana ◽  
Balasubramanian Rathina Kumari ◽  
Devarajulu Nisha Nandhini
Keyword(s):  
Rat Brain ◽  
Cynodon Dactylon ◽  
Brain Regions ◽  
Protective Role ◽  
Rat Brain Regions

Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)—induced oxidative damage in Leydig cells

2005 ◽  
Vol 39 (11) ◽  
pp. 1259-1272 ◽  
Author(s):  
Palaniappan Murugesan ◽  
Thirupathi Muthusamy ◽  
Karundevi Balasubramanian ◽  
Jagadeesan Arunakaran
Keyword(s):  
Vitamin C ◽  
Oxidative Damage ◽  
Leydig Cells ◽  
Polychlorinated Biphenyl ◽  
Protective Role ◽  
Aroclor 1254

scholarly journals Selective vulnerability to kainate-induced oxidative damage in different rat brain regions

2001 ◽  
Vol 21 (5) ◽  
pp. 403-407 ◽  
Author(s):  
Eduardo Candelario-Jalil ◽  
Saied Mohammed Al-Dalain ◽  
Rubén Castillo ◽  
Gregorio Martínez ◽  
Olga Sonia León Fernández
Keyword(s):  
Oxidative Damage ◽  
Rat Brain ◽  
Selective Vulnerability ◽  
Brain Regions ◽  
Rat Brain Regions

Oxidative stress modulates membrane bound ATPases in brain regions of PCB (Aroclor 1254) exposed rats: Protective role of α-tocopherol

2007 ◽  
Vol 61 (7) ◽  
pp. 435-440 ◽  
Author(s):  
N. Sridevi ◽  
P. Venkataraman ◽  
K. Senthilkumar ◽  
G. Krishnamoorthy ◽  
J. Arunakaran
Keyword(s):  
Oxidative Stress ◽  
Brain Regions ◽  
Protective Role ◽  
Aroclor 1254 ◽  
Membrane Bound

scholarly journals Protective role of maize purple plant pigment against oxidative stress in fluorosis rat brain

2020 ◽  
Vol 11 (1) ◽  
pp. 89-95
Author(s):  
Boyan Li ◽  
Keyana Nozzari Varkani ◽  
Lu Sun ◽  
Bo Zhou ◽  
Xiaohong Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Rat Brain ◽  
Neuronal Apoptosis ◽  
Protective Role ◽  
Fluoride Toxicity ◽  
Plant Pigment

AbstractIn fluorosis-endemic areas, exposure to high levels of fluoride causes neurotoxicity such as lowered intelligence and cognitive impairment. Oxidative damage is critical to pathophysiologic processes of fluoride intoxication, and neurotoxicity of fluoride may be associated with oxidative stress. In previous studies, maize purple plant pigment (MPPP), which was rich in anthocyanins, showed a strong scavenging activity in vitro and in vivo. The present study aimed to determine whether treatment with MPPP can alleviate fluoride-induced oxidative damage in rat brain. After 3 months of experiment, brain tissues were assayed for oxidative stress variables, histological and Western blotting examinations. Our results showed that MPPP reduced the elevated malondialdehyde levels, increased superoxide dismutase activity, and further attenuated histopathological alterations and mitigated neuronal apoptosis. Importantly, MPPP also reversed changes in Bax and Bcl-2. Therefore, it was speculated that MPPP protects brain tissue from fluoride toxicity through its antioxidant capacity.

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